2 results match your criteria: "Sun Yat-sen University 1st Affiliated Hospital[Affiliation]"
The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.
Kaohsiung J Med Sci
February 2024
Department of Neurosurgery, Sun Yat-sen University 1st Affiliated Hospital, Guangzhou, China.
Article Synopsis
- Temozolomide (TMZ) resistance is a major hurdle in treating gliomas, and this study investigates the role of lysine demethylase 4A (KDM4A) in this context.
- Researchers tested KDM4A levels in glioma cells and examined how targeting KDM4A with siRNA affects cell viability and TMZ effectiveness.
- The study found that KDM4A enhances TMZ resistance by promoting ROCK2 expression and interacting with HUWE1, suggesting that targeting KDM4A could improve glioma treatment outcomes.
Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection.
Am J Transplant
September 2016
Immunobiology & Transplant Science Center, Houston Methodist Hospital and Houston Methodist Research Institute, Texas Medical Center, Houston, TX.
Macrophages exhibit diverse phenotypes and functions; they are also a major cell type infiltrating chronically rejected allografts. The exact phenotypes and roles of macrophages in chronic graft loss remain poorly defined. In the present study, we used a mouse heart transplant model to examine macrophages in chronic allograft rejection.
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