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The Mediating Role of Sleep Quality in the Association Between Negative Affect and Cognitive Function Among Patients With Nasopharyngeal Carcinoma After Intensity-Modulated Radiotherapy.

Cancer Nurs

October 2024

Author Affiliations: School of Nursing, Sun Yat-sen University (Dr Zhang); Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center (Ms Fan); and Hospital of Stomatology, Sun Yat-sen University (Ms Chen and Mr Yan), Guangzhou, Guangdong, People's Republic of China.

Background: Cognitive function impairment is a severe yet largely unrecognized adverse reaction among patients with nasopharyngeal carcinoma (NPC) following radiotherapy.

Objectives: The aims of this study were to examine the level of cognitive function, explore the influencing factors of the cognitive function of NPC after intensity-modulated radiotherapy (IMRT), and identify the mediating role of sleep quality between negative affect and cognitive function.

Methods: In total, 200 patients with NPC after IMRT were recruited from a tertiary cancer center in Southern China between September 2020 and March 2021.

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