The pathogenesis and management of heatstroke and heatstroke-induced lung injury.

In the past two decades, record-breaking heat waves have caused an increasing number of heat-related deaths, including heatstroke, globally. Heatstroke is a life-threatening systemic condition characterized by a core body temperature >40°C and the subsequent development of multiple organ dysfunction syndrome. Lung injury is a well-documented complication of heatstroke and is usually the secondary cause of patient death.

Effect of Mesenchymal Stem Cell-Derived Extracellular Vesicles Induced by Advanced Glycation End Products on Energy Metabolism in Vascular Endothelial Cells.

Introduction: Advanced glycation end products (AGEs) play a critical role in the development of vascular diseases in diabetes. Although stem cell therapies often involve exposure to AGEs, the impact of this environment on extracellular vesicles (EVs) and endothelial cell metabolism remains unclear.

Methods: Human umbilical cord mesenchymal stem cells (MSCs) were treated with either 0 ng/ml or 100 ng/ml AGEs in a serum-free medium for 48 hours, after which MSC-EVs were isolated.

Unveiling Cryptic Diversity in Hylomys: A Commentary on Recent Taxonomic Revisions.

The genus Hylomys now comprises seven species instead of two; the Hylomys species in China should be classified as Hylomys peguensis.

Specific Enrichment of Carrying Microorganisms with Nitrogen Fixation and Dissimilatory Nitrate Reduction Function Enhances Arsenic Methylation in Plant Rhizosphere Soil.

Plants can recruit microorganisms to enhance soil arsenic (As) removal and nitrogen (N) turnover, but how microbial As methylation in the rhizosphere is affected by N biotransformation is not well understood. Here, we used acetylene reduction assay, gene amplicon, and metagenome sequencing to evaluate the influence of N biotransformation on As methylation in the rhizosphere of , a potential As hyperaccumulator. was grown in mining soils (MS) and artificial As-contaminated soils (AS) over two generations in a controlled pot experiment.

Passivating Lattice Oxygen in ZnO Nanocrystals to Reduce its Interactions with the Key Intermediates for a Selective Photocatalytic Methane Oxidation to Methanol.

An inevitable overoxidation process is considered as one of the most challenging problems in the direct conversion of methane (CH4) to methanol (CH3OH), which is limited by the uncontrollable cracking of key intermediates. Herein, we have successfully constructed a photocatalyst, the Fe-doped ZnO hollow polyhedron (Fe/ZnOHP), for the highly selective photoconversion of CH4 to CH3OH under mild conditions. In-situ experiments and density functional theory calculations confirmed that the introduction of Fe was able to decrease the energy level of the O 2p orbital, which passivated the activity of lattice oxygen in ZnO nanocrystals.

Effects of population aging on quality of life and disease burden: a population-based study.

Background: As population aging intensifies, it becomes increasingly important to elucidate the casual relationship between aging and changes in population health. Therefore, our study proposed to develop a systematic attribution framework to comprehensively evaluate the health impacts of population aging.

Methods: We used health-adjusted life expectancy (HALE) to measure quality of life and disability-adjusted life years (DALY) to quantify the burden of disease for the population of Guangzhou.

Construction of a prognostic model for gastric cancer based on immune infiltration and microenvironment, and exploration of MEF2C gene function.

Background: Advanced gastric cancer (GC) exhibits a high recurrence rate and a dismal prognosis. Myocyte enhancer factor 2c (MEF2C) was found to contribute to the development of various types of cancer. Therefore, our aim is to develop a prognostic model that predicts the prognosis of GC patients and initially explore the role of MEF2C in immunotherapy for GC.

Integrated analysis of the prevalence and influencing factors of poststroke dysphagia.

Objectives: Poststroke dysphagia (PSD) is a common complication after stroke but there is limited information on its global prevalence and influencing factors, such as spatial, temporal, demographic characteristics, and stroke-related factors. Our study seeks to fill this knowledge gap by exploring the overall prevalence of PSD and its influencing factors.

Methods: A search of English-language literature from database inception from 2005 until May 2022 was performed using PubMed, Embase, Web of Science, Cochrane Library, and Scopus.

Electronic structure modulation of ultrathin PtRuMoCoNi high-entropy alloy nanowires for boosting peroxidase-like activity and sensitive colorimetric determination of isoniazid and hydrazine.

Self-supported ultrathin PtRuMoCoNi high-entropy alloy nanowires (HEANWs) were synthesized by a one-pot co-reduction method, whose peroxidase (POD)-like activity and catalytic mechanism were elaborated in detail. As expected, the PtRuMoCoNi HEANWs showed excellent POD-like activity. It can quickly catalyze the oxidization of colorless 3,3',5,5'-tetramethylbenzidine (TMB) to blue TMB through decomposition of HO to superoxide radicals.

Fig abscission as a defense mechanism of Ficus trees against parasitism by non-pollinating fig wasps.

How does the fig tree Ficus benguetensis protect its investment in the production of figs and pollinating fig wasps against parasitism from non-pollinating fig wasps? This study documents a previously overlooked defense mechanism: fig abscission-the natural shedding of the fig fruit as a defense mechanism. Our bagging experiments showed that both the absence of pollination and high parasitism levels lead to the abortion of F. benguetensis figs, with positive correlations between parasitism levels, increased abscission rates, and decreased pollinator production.

Recent changes in ENSO's impacts on the summertime circumglobal teleconnection and mid-latitude extremes.

The boreal summer circumglobal teleconnection (CGT) provides a primary predictability source for mid-latitude Northern Hemisphere climate anomalies and extreme events. Here, we show that the CGT's circulation structure has been displaced westward by half a wavelength since the late 1970s, more severely impacting heatwaves and droughts over East Europe, East Asia, and southwestern North America. We present empirical and modelling evidence of the essential role of El Niño-Southern Oscillation (ENSO) in shaping this change.

Saturated F2-rings from Alkenes.

A general method to convert simple exocyclic alkenes (no Ar-substituents) into saturated F2-rings has been developed. The reaction involves the IIII-reagent C6F5I(OAc)2 (F5-PIDA). The reaction efficiently works on the mg-, g-, and even multigram scale.

Association of a healthy lifestyle index with anthropometric indices and obesity in Hong Kong Chinese women: Evidence from the MECH-HK cohort study.

Aim: This cross-sectional study aimed to examine the associations of a healthy lifestyle index (HLI) with several anthropometric indices and obesity among Hong Kong Chinese women.

Subjects/methods: A total of 3174 women (56.16 ± 8.

Gut microbial GABA imbalance emerges as a metabolic signature in mild autism spectrum disorder linked to overrepresented Escherichia.

Gut microbiota (GM) alterations have been implicated in autism spectrum disorder (ASD), yet the specific functional architecture remains elusive. Here, employing multi-omics approaches, we investigate stool samples from two distinct cohorts comprising 203 children with mild ASD or typical development. In our screening cohort, regression-based analysis for metabolomic profiling identifies an elevated γ-aminobutyric acid (GABA) to glutamate (Glu) ratio as a metabolic signature of ASD, independent of age and gender.

Innovative prediction and causal analysis of accident vehicle towing probability using advanced gradient boosting techniques on extensive road traffic scene data.

Accurate prediction and causal analysis of road crashes are crucial for improving road safety. One critical indicator of road crash severity is whether the involved vehicles require towing. Despite its importance, limited research has utilized this factor for predicting vehicle towing probability and analyzing its causal factors.

Retrospective comparative survival analysis of ablation plus systemic therapy versus systemic therapy alone for breast cancer liver metastases, stratified by extrahepatic metastases status.

Background: Current decision-making for the treatment of breast cancer liver metastases (BCLM) using ablation lacks strong evidence, especially for patients combined with extrahepatic metastases.

Purpose: To assess whether ablation plus systemic therapy (AS) improves survival outcomes in patients with BCLM compared to systemic therapy alone.

Materials And Methods: This retrospective study analyzed patients with BCLM who received either AS or systemic therapy alone.

Optimized detection of calcium ion in serum using constant potential coulometry with metastable liquid-liquid contact doping enhanced PEDOT: PSS ink.

Highly stable calcium ion selective electrodes (Ca-ISEs) were developed by drop-casting a layer of poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT: PSS) as an ion-to-electron transfer layer onto Au electrode. The conductive PEDOT: PSS ink was prepared using a metastable liquid-liquid contact (MLLC) doping method, which induced phase separation, removed excess PSS, and significantly enhanced charge transfer kinetics and conductivity. The resulting Ca-ISEs exhibited excellent electrochemical performance.

Accelerating the Future of Oncology Drug Development: The Role of Consortia in the Delivery of Precision Oncology Early Phase Clinical Trials.

Purpose: Over the past 15 years, the landscape of early phase clinical trials (EPCTs) has undergone a remarkable expansion in both quantity and intricacy. The proliferation of sites, trials, sponsors, and contract research organizations has surged exponentially, marking a significant shift in research conduct. However, EPCT operations suffer from numerous inefficiencies, such as cumbersome start-up processes, which are particularly critical when drug safety and the recommended phase II dose need to be established in a timely manner.

ADARp110 promotes hepatocellular carcinoma progression via stabilization of CD24 mRNA.

ADAR is highly expressed and correlated with poor prognosis in hepatocellular carcinoma (HCC), yet the role of its constitutive isoform ADARp110 in tumorigenesis remains elusive. We investigated the role of ADARp110 in HCC and underlying mechanisms using clinical samples, a hepatocyte-specific knock-in mouse model, and engineered cell lines. ADARp110 is overexpressed and associated with poor survival in both human and mouse HCC.

Standard: Human gastric organoids.

Organoid technology provides a transformative approach to understand human physiology and pathology, offering valuable insights for scientific research and therapeutic development. Human gastric organoids, in particular, have gained significant interest for applications in disease modeling, drug discovery, and studies of tissue regeneration and homeostasis. However, the lack of standardized quality control has limited their extensive clinical applications.

Epigenetics in the modern era of crop improvements.

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades, our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits.

Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis.

Purpose: Fungal keratitis (FK) remains a treatment challenge, necessitating new therapeutic targets. Piezo1, a mechanosensitive ion channel, regulates calcium signaling and immune cell function. This study investigates its role in macrophage-mediated antifungal responses in FK.