Decreased RNA mA methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.

RNA N-methyladenosine (mA) modification is gradually thought to be an active participant in the considerable biological processes of glioblastoma (GB), providing us with a novel insight for exploring this disease. However, the role of RNA mA modification during the epithelial mesenchymal transition (EMT) or vasculogenic mimicry (VM) progression has not been investigated in GB. Here we performed a research to validate the impact exerted by AlkB homolog 5 (ALKBH5), one of "erasers" for RNA mA and methyltransferase-like 3 (METTL3) which adds mA modification to the RNAs on the progression of EMT and VM in GB.