Machine learning-based pathomics model predicts ANGPT2 expression and prognosis in hepatocellular carcinoma.

Angiopoietin 2 (ANGPT2) is a promising prognostic marker and therapeutic target in hepatocellular carcinoma (HCC). However, assessing ANGPT2 expression and prognosis from histopathological images with naked eye is challenging. In this study, machine learning was employed to develop a pathomics model that analyzed histopathological images to predict ANGPT2 status.

Conference 2024: Building an innovative scientific research ecosystem for microbiome and One Health.

The Conference 2024 provides a platform to promote the development of an innovative scientific research ecosystem for microbiome and One Health. The four key components - Technology, Research (Biology), Academic journals, and Social media - form a synergistic ecosystem. Advanced technologies drive biological research, which generates novel insights that are disseminated through academic journals.

Trace amount of taurine leveling agent for stable Zn anode.

Aqueous zinc-ion batteries are highly praised for their cost-effectiveness, environmental friendliness, and high safety, making them an ideal choice for next-generation energy storage systems. However, the practical application of Zn metal anodes is constrained by well-known challenges such as dendrite growth and significant interfacial side reactions. This study introduces a trace amount of taurine (TAU) as a leveling additive into the electrolyte to optimize the microstructure of the electrolyte and the anode interface chemistry.

Combined pyrotinib and fulvestrant for hormone receptor-positive and HER2-positive metastatic breast cancer: A multicenter, single-arm, phase II trial.

This multicenter, single-arm, phase II clinical trial (NCT04034589) evaluated the efficacy and safety of pyrotinib combined with fulvestrant in patients with HR-positive/HER2-positive metastatic breast cancer who had experienced trastuzumab treatment failure. A total of 46 patients were enrolled, receiving pyrotinib orally once daily and fulvestrant intramuscularly on days 1 and 15 of cycle 1, followed by monthly doses on day 1. The primary endpoint was progression-free survival (PFS), while secondary endpoints included overall survival (OS), objective response rate (ORR), disease control rate (DCR), and safety.

Effects of School-Based Lifestyle Interventions on Cardiovascular Health in Chinese Children and Adolescents: A Post Hoc Analysis of a National Multicenter Study.

Background: We evaluated the effects of a national school-based lifestyle intervention program against childhood obesity on improving cardiovascular health (CVH), assessed using the recently introduced Life's Essential 8 metric framework.

Methods And Results: Our post hoc analysis of the national school-based lifestyle intervention targeting diet and physical activity included 94 schools with eligible students aged 7 to 17 years (intervention group n=30 629; control group n=26 581). We assessed CVH metrics by individual scores for 4 health behaviors (diet, physical activity, nicotine exposure, and body mass index) and 3 health factors (blood lipids, glucose, and pressure).

Mitochondrial DNA copy number variation and gene mutations mediate polycystic ovary syndrome: research progress.

Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder affecting women of reproductive age. We provide an overview of how mitochondrial DNA (mtDNA) copy number variation (CNVs) and gene mutations mediate PCOS, including current research findings and clinical trial data to underscore a theoretical basis for further exploring its pathogenesis and developing targeted therapy. Characterized by hyperandrogenism, oligo-ovulation or anovulation, and polycystic ovarian morphology, PCOS is often accompanied by insulin resistance, metabolic syndrome, and chronic inflammation, which reduce fertility throughout the reproductive lifespan.

Multimodal data fusion AI model uncovers tumor microenvironment immunotyping heterogeneity and enhanced risk stratification of breast cancer.

Breast cancer is the leading cancer among women, with a significant number experiencing recurrence and metastasis, thereby reducing survival rates. This study focuses on the role of long noncoding RNAs (lncRNAs) in breast cancer immunotherapy response. We conducted an analysis involving 1027 patients from Sun Yat-sen Memorial Hospital, Sun Yat-sen University, and The Cancer Genome Atlas, utilizing RNA sequencing and pathology whole-slide images.

 sp. nov. from Guangxi, with a key and checklist of Chinese species and additional records of Zimmermann, 1924 from China (Coleoptera, Dytiscidae, Hydroporinae, Hyphydrini).

A new species from Guangxi, China is described. New records are provided for the following species: Wewalka, 2000 and Wewalka, 2000 from Zhejiang, and Bian, Guo & Ji, 2013 from Guizhou. Additional records are also given for some other Chinese species.

Investigating the photophysical properties of rhodamines using a spectroscopic single-molecule fluorescence method.

The photophysical properties of rhodamine molecules play a critical role in their performance across various applications. The spectroscopic single-molecule fluorescence (sSMF) technique overcomes the limitations of conventional SMF by distinguishing individual fluorophores based on their emission spectra. This enables precise measurement and direct comparison of photophysical properties among distinct molecules under identical conditions, without requiring separation of molecules.

Rare-earth element doped NiFe-MOFs as efficient and robust bifunctional electrocatalysts for both alkaline freshwater and seawater splitting.

Based on the target of carbon neutrality, it is very important to explore highly active and durable electrocatalysts for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Herein, a series of NiFe-based metal-organic frameworks (MOFs) with the doping of various rare-earth elements (Ce, Y, and La) were grown on nickel foam by a facile solvothermal process. The representative CeNiFe-MOF showed amazing OER performance with ultralow overpotentials of 224 and 277 mV at 500 mA cm in 1.

Remote C-H bond cooperation strategy enabled silver catalyzed borrowing hydrogen reactions.

Metal-ligand cooperation (MLC) is an essential strategy in transition metal catalysis. Traditional NH-based and OH-based MLC catalysts, as well as the later developed (de)aromatization strategy, have been widely applied in atom-economic borrowing hydrogen/hydrogen auto-transfer (BH/HA) reactions. However, these conventional MLC approaches are challenging for low-coordination and low-activity coinage metal complexes, arising from the instability during (de)protonation on the coordination atom, the constraint in linear coordination, and possible poisoning due to extra functional sites.

An effective design strategy for thermally activated delayed fluorescence emitters with aggregation-induced emission to enable sky-blue OLEDs that achieve an EQE of nearly 30.

Pure organic thermally activated delayed fluorescence (TADF) materials hold great promise for efficient organic light-emitting diodes (OLEDs), yet developing high-performance blue TADF materials that integrate short delayed lifetime with aggregation-induced emission (AIE) properties remains a significant challenge. In this study, we developed three highly-efficient blue TADF emitters (32clCBP, 32clCXT and 32PclCXT) featuring AIE character by integrating rigid π-extended donors with different acceptors. Notably, the doped 32PclCXT film achieved an exceptionally high photoluminescence quantum efficiency of up to 99% and a short delayed lifetime of 1.

Decreased expression of promotes apoptosis through the Hippo-YAP1 signaling pathway leading to diabetic erectile dysfunction.

Long non-coding RNAs (lncRNAs) primarily engage with mRNA, DNA, proteins, and microRNAs (miRNAs), thereby regulating gene expression; however, its specific role in diabetic erectile dysfunction (DED) has not been studied. This study aims to investigate the effects and mechanisms of in DED. The differential target gene was identified in the penile tissues of rats with DED through bioinformatics analyses.

A polymer deposition-mediated surface-charge reformation strategy: reversing the MOF biomineralization behavior.

Biomineralization of a porous metal-organic framework (MOF) shell onto biomacromolecule templates is a burgeoning strategy to construct robust biocatalysts. However, it strongly relies on the interfacial interaction between MOF precursors and enzyme surface, significantly limiting the generalization of this nanotechnology. Herein, we identify polymers that are well-suited for deposition onto target biomacromolecules supramolecular interactions and introduce a polymer deposition-mediated surface-charge reformation strategy to facilitate the biomineralization of porous MOFs, including ZIF-8, ZIF-90, and ZIF-zni onto enzymes.

Tailoring hierarchical MnO nanostructures on self-supporting cathodes for high-mass-loading zinc-ion batteries.

Aqueous zinc-ion batteries (AZIBs) with MnO cathodes have promising application prospects; however, their performance is hindered by their low efficiency and insufficient life. By leveraging the nanomicellar properties of cetyltrimethylammonium bromide (CTAB), a hierarchical δ-MnO with 2D/3D structure was directionally grown on a modified carbon cloth (CC) collector for realizing high-mass-loading AZIBs. Experimental results reveal the synergistic effects of micro/nano hierarchically structured MnO-CC heterointerfaces in accelerating the electron migration and transfer rate of Zn/H.

Diphosphaenones: beyond the phosphorus analogue of enones.

Phosphaenones, like their carbon analogue enones (C[double bond, length as m-dash]C-C[double bond, length as m-dash]O), are promising building blocks for synthetic chemistry and materials science. However, in contrast to the α- and β-phosphaenones, structurally and spectroscopically well-defined diphosphaenones (DPEs) are rare. In this study, we disclose the isolation and spectroscopic characterization of N-heterocyclic vinyl (NHV) substituted acyclic DPEs 3a,b [NHV-P[double bond, length as m-dash]P-C(O)-NHV].

The tissue and circulating cell-free DNA-derived genetic landscape of premalignant colorectal lesions and its application for early diagnosis of colorectal cancer.

Colorectal adenomas (CRAs) represent precancerous lesions that precede the development of colorectal cancer (CRC). Regular monitoring of CRAs can hinder the progression into carcinoma. To explore the utility of tissue DNA and circulating cell-free DNA (cfDNA) in early diagnosis of CRC, we retrospectively sequenced paired tissue and plasma samples from 85 patients with conventional CRAs.

Hepatic arterial infusion chemotherapy in combination with lenvatinib and durvalumab versus standard first-line treatment gemcitabine and cisplatin plus durvalumab in advanced intrahepatic cholangiocarcinoma.

In patients with advanced intrahepatic cholangiocarcinoma (ICC), clinical outcomes remain unsatisfactory despite the recommended first-line treatment of gemcitabine with cisplatin and durvalumab (GCD). We recently reported that hepatic arterial infusion chemotherapy (HAIC) in combination with lenvatinib and durvalumab (HLD) exhibited promising antitumor activity and manageable adverse events in patients with unresectable ICC. Here, we aimed to compare HLD with GCD in patients with advanced ICC.

Melatonin attenuates degenerative disc degression by downregulating DLX5 via the TGF/Smad2/3 pathway in nucleus pulposus cells.

Background: Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, and apoptosis plays a key role in its pathogenesis. Distal-less homeobox 5 (Dlx5) has been reported to induce cell apoptosis. Melatonin, as a powerful antiapoptotic agent, has been widely reported.

Association Between Noninvasive Liver Fibrosis Scores and Heart Failure in a General Population.

Background: The association between nonalcoholic fatty liver disease and cardiovascular disease is firmly established, yet the association between noninvasive liver fibrosis scores and cardiovascular events remains a topic of uncertainty. Our study aimed to explore the association between liver fibrosis and heart failure.

Methods And Results: The data set was from the National Health and Nutrition Examination Survey 2011 to 2018.

Sub-region based histogram analysis of amide proton transfer-weighted MRI for predicting tumor budding grade in rectal adenocarcinoma: a prospective study.

Objective: To explore the sub-regional histogram features of amide proton transfer-weighted (APTw) MRI, compared with those of diffusion-weighted imaging (DWI), in predicting the tumor budding (TB) grade of rectal cancer (RC).

Materials And Methods: This study prospectively enrolled 74 patients with pathologically confirmed RC, who underwent APTw MRI before surgery from July 2022 to March 2023. Hematoxylin-eosin staining was used for TB scoring.