Mechanism for Implementing the State Guarantee Program for Medical Services at the Primary Level.

Objective: Aim: The goal of this work is to investigate the effectiveness of state regulatory tools influencing the HCS reform process and the institutional support for the implementation of SGPMS at the primary level.

Patients And Methods: Materials and Methods: To evaluate the effectiveness of SGPMS implementation at the primary level, methods of observation, analysis and synthesis, grouping, and generalization were applied.

Results: Results: In the implementation of SGPMS, PMC is prioritized.

Mental Health Assessment of the Population: Study Protocol of the MAP Research Program in Ukraine (MAP-U) and in Zurich (MAP-Z).

Objectives: To conduct mental health surveillance in adults in Ukraine and Ukrainian refugees (Canton of Zurich, Switzerland) as an actionable scientific foundation for public mental health and mental healthcare.

Methods: Mental Health Assessment of the Population (MAP) is a research program including prospective, population-based, digital cohort studies focused on mental health monitoring. The study aims to include 17,400 people from the general population of Ukraine, 1,220 Ukrainians with refugee status S residing in the canton of Zurich, and 1,740 people from the Zurich general population.

Modification of Ti13Nb13Zr Alloy Surface via Plasma Electrolytic Oxidation and Silver Nanoparticles Decorating.

The dynamically developing field of implantology requires researchers to search for new materials and solutions. In this study, TiNbZr samples were investigated as an alternative for popular, but potentially hazardous TiAl6V4. Samples were etched, sandblasted, subjected to PEO, and covered in AgNP suspension.

Improving diagnostics and surveillance of malaria among displaced people in Africa.

African communities that have been forced to leave their homes experience a considerably greater susceptibility to malaria as a result of densely populated living conditions, restricted availability of healthcare, and environmental influences. Internally displaced individuals frequently live in large settlements with restricted availability to drinking water, essential sanitation, and medical services, intensifying the spread of malaria. As a result, the occurrence of malaria is significantly more common among refugees and internally displaced individuals compared to those who are not displaced.

Superior hypophyseal artery aneurysm: microsurgical vs. endovascular treatment.

This study aimed to provide an updated evidence of superior hypophyseal artery (SHA) aneurysms management, including their clinical implications, predictive factors for rupture, therapeutic approaches, and post-treatment outcomes. This systematic review and meta-analysis, following PRISMA guidelines, assessed the literature on superior hypophyseal artery aneurysms. Studies were selected based on predefined criteria, focusing on coiling and clipping interventions.

Electrospun Chitosan/Polylactic Acid Nanofibers with Silver Nanoparticles: Structure, Antibacterial, and Cytotoxic Properties.

Electrospinning, a technique for creating fabric materials from polymer solutions, is widely used in various fields, including biomedicine. The unique properties of electrospun fibrous membranes, such as large surface area, compositional versatility, and customizable porous structure, make them ideal for advanced biomedical applications like tissue engineering and wound healing. By considering the high biocompatibility and well-known regenerative potential of polylactic acid (PLA) and chitosan (CH), as well as the versatile antibacterial effect of silver nanoparticles (AgNPs), this study explores the antibacterial efficacy, adhesive properties, and cytotoxicity of electrospun chitosan membranes with a unique nanofibrous structure and varying concentrations of AgNPs.

Tunable TiZrMoC Coatings: A Comprehensive Study of Microstructure, Mechanical Properties, and Wear Resistance.

TiZrMoC coatings were deposited on Si(100) substrates using a DC dual magnetron sputtering. The composition was controlled by adjusting the sputtering parameters of the TiZrMo and graphite targets. The influence of graphite target current on the resulting coating properties was explored.

Study of the Thermal Decomposition Process of Explosive Mixtures Based on Hydrogen Peroxide.

In this work, we have investigated the thermal features of hydrogen peroxide-based energetic materials formulations. Initial research has shown that both the auxiliary oxidiser (sodium nitrate, potassium nitrate or calcium nitrate) and sensitising agent (glass microspheres) have significant influence on the rate of hydrogen peroxide decay in such formulations. In terms of the thermal features of the tested energetic materials, a similar and significant influence of the auxiliary oxidising agent and sensitising agent choice was observed.

Epilepsy Surgery for Drug-Resistant Epilepsy in Africa: A Systematic Review.

Background And Objectives: Nearly one-third of individuals with epilepsy have drug-resistant epilepsy, treated most effectively with surgery. This study aims to discuss the demographic profile, surgical access, and strategies used in drug-resistant epilepsy in Africa.

Methods: A systematic review was performed using PubMed, Google Scholar, Embase, and Web of Science in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines.

Dandy-Walker syndrome: a bibliometric analysis of the most 100 cited articles.

Introduction: Dandy-Walker syndrome (DWS), a complex neurodevelopmental disorder, has intrigued clinicians and researchers since its description by physicians Walter Dandy and Arthur Walker. Despite its recognition for nearly a century, understanding its etiology, pathogenesis, and clinical manifestations remains elusive. This bibliometric analysis aims to elucidate influential academic works on DWS.

Elucidation of Potential Genotoxicity of MXenes Using a DNA Comet Assay.

MXenes are among the most diverse and prominent 2D materials. They are being explored in almost every field of science and technology, including biomedicine. In particular, they are being investigated for photothermal therapy, drug delivery, medical imaging, biosensing, tissue engineering, blood dialysis, and antibacterial coatings.

Exploring the current provision of pancreatic transplantations in low- and middle-income countries: Current landscape, challenges, future prospects.

This comprehensive review addresses the global health challenge of disparities in pancreas transplant access, particularly in low- and middle-income countries (LMICs) compared to high-income countries. Despite advancements in surgical techniques and immunosuppression for procedures like simultaneous pancreas-kidney, pancreas-after-kidney, and pancreas-transplant alone, LMICs face significant challenges, including limited infrastructure, financial constraints, and a shortage of skilled medical professionals. Donation after brain death remains constrained by sociocultural barriers.

Soft Tissue Sarcoma in Sub-Saharan Africa: Surgical Management Outcomes, Gaps, and Future Prospects: A Narrative Review.

Background And Aims: The diagnosis and management of soft tissue sarcoma (STS) in sub-Saharan Africa (SSA) present significant challenges. Positive outcomes in STS treatment include achieving negative margins, improved quality of life, and reduced recurrence rates, while negative outcomes involve incomplete resection, local recurrence, and surgical complications. This review aims to examine the current state of STS management in SSA, identify key challenges, and propose potential solutions to improve patient outcomes.

Emerging technologies for the management of diabetic foot ulceration: a review.

Diabetic foot ulcers (DFUs) and infections are common complications that frequently result in reduced quality of life and even morbidity for patients with diabetes. This paper highlights significant findings in DFU treatments and emerging advanced technologies for monitoring ulceration in patients with diabetes. The management of DFUs requires a multidisciplinary approach that involves patient education.

Effect of radiation-induced vacancy saturation on the first-order phase transformation in nanoparticles: insights from a model.

By employing a model of nanomaterials with polymorphic phase transitions and using a thermodynamic approach to describe the effects of vacancy saturation, irradiation dose, powder dispersion, and surface energies, we demonstrate the possibility of radiation-induced phase transitions and the zones of radiation stability for nanoparticles. We utilize nanoparticles exhibiting transitions from the body-centered cubic α phase to the face-centered cubic β phase, and the reverse transition from β phase to α phase, as a model system for first-order phase transformations. We incorporate nucleation through the appearance and growth of the nucleus of a new phase, resulting in the formation of a two-phase α+β system, and we highlight the importance of accounting for nucleation.

Innovative development of territories based on the integrated use of social, resource and environmental potential.

This article investigates the interrelationships and interdependencies inherent in the integrated use of the territory's social, resource, and environmental potential to achieve its sustainable development. The basic hypotheses formulated during this study were as follows: Sustainable development of the territory's resource and ecological potential cannot be achieved if its social potential is reduced; Sustainable development of the territory's ecological and social potential can be achieved only if it is economically feasible, that is if it contributes to the sustainable development of the territory's resource potential; Sustainable development of the territory's resource and social potential cannot be achieved while its ecological potential deteriorates; Ensured sustainable development of territories in today's world is only possible with simultaneous integrated use of the territory's social, resource, and environmental potential. The aim of this research is to investigate the interrelationships among these three components and to determine their impact on the overall development of the regions.

Analyzing the influence of electric vehicle charging scheduling on distribution transformer lifespan.

The ongoing growth in global electricity demand and rapid proliferation of electric vehicles (EVs) are posing challenges to the operation of the low voltage power networks and their components. This study aims to analyze the impacts of peak-load demand on the distribution transformers, considering mild and extreme combinations of electric energy demand and localized charging of plug-in EVs under their different penetration levels, hypothesizing that shifting the demand for charging throughout the day can reduce the aging of distribution transformers. The proposed method employs a fuzzy-logic-based tool, which incorporates the influence of ambient temperature, higher harmonics, reactive power compensation, reverse power flows, and overload.

Genes to therapy: a comprehensive literature review of whole-exome sequencing in neurology and neurosurgery.

Whole-exome sequencing (WES), a ground-breaking technology, has emerged as a linchpin in neurology and neurosurgery, offering a comprehensive elucidation of the genetic landscape of various neurological disorders. This transformative methodology concentrates on the exonic portions of DNA, which constitute approximately 1% of the human genome, thus facilitating an expedited and efficient sequencing process. WES has been instrumental in advancing our understanding of neurodegenerative diseases, neuro-oncology, cerebrovascular disorders, and epilepsy by revealing rare variants and novel mutations and providing intricate insights into their genetic complexities.

The power of three: Retatrutide's role in modern obesity and diabetes therapy.

The increasing prevalence of obesity and type 2 diabetes mellitus has resulted in a significant challenge to public health throughout the globe. It required the development of novel therapeutic approaches. Retatrutide is a groundbreaking triple agonist that targets glucagon receptors, gastric inhibitory polypeptide, and glucagon-like peptide-1.

Isolated Sixth Cranial Nerve Palsy in Patients with Pituitary Apoplexy.

Background:  Pituitary apoplexy is an acute clinical syndrome constituted by headache, visual impairment, ophthalmoplegia, and altered mental status. Abducens nerve palsy due to pituitary apoplexy is a significant clinical manifestation in pituitary apoplexy cases.This study aims to investigate the rare occurrence of isolated sixth cranial nerve palsy in patients with pituitary apoplexy, a condition characterized by sudden hemorrhagic or ischemic infarction of the pituitary gland.

Effect of Thermal Processing on the Structural and Magnetic Properties of Epitaxial CoFeGe Films.

The structure and magnetic properties of epitaxial Heusler alloy films (CoFeGe) deposited on MgO (100) substrates were investigated. Films of 60 nm thickness were prepared by magnetron co-sputtering at different substrate temperatures (T), and those deposited at room temperature were later annealed at various temperatures (T). X-ray diffraction confirmed (001) [110] CoFeGe || (001) [100] MgO epitaxial growth.

Anxiety among Ukrainian academic staff during wartime.

The ongoing war in Ukraine has significantly impacted the mental health of academic staff, with anxiety emerging as a predominant issue. This study aimed to assess the prevalence and severity of generalized anxiety disorder (GAD) among Ukrainian academic staff and determine the influence of sociodemographic factors, such as gender, age, migration status, scientific degree, and job title, on anxiety levels. The research was conducted using a cross-sectional online survey between December 2023 and February 2024.

Updates in pharmacotherapy of obesity.

Obesity is now recognized as a chronic, progressive condition requiring early intervention and long-term management to achieve health benefits and improve metabolic risk factors. The main objective of obesity pharmacotherapy is weight loss and weight loss maintenance. There is increasing acceptance of anti-obesity medications as an adjunct to lifestyle modifications and/or surgery.