[New approaches for pathology teaching in undergraduate medical studies, the University Paris-Saclay experience].

Introduction: Teaching pathology is an essential and early part of the medical curriculum. It is classically theoretical, often accompanied by tutorials. Access to pathology internships for students is not always possible.

[Rheumatology: what's new in 2024].

In 2024, CD19-CAR T cells are ubiquitous in rheumatology, with incredible therapeutic results in cases of severe and refractory disease. This major advance confirms the interest of the B lymphocyte as a therapeutic target, and also suggests the real possibility of a drug-free remission, at the price of minor and minimal side effects for the time being. However, the necessary perspective is still lacking for a therapy that remains out of reach because of its price.

[Pediatrics. Diagnosis of generalized joint hypermobility in children].

Joint hypermobility is a common feature in children and adolescents, often physiological and benign, but it is also a manifestation of hereditary connective tissue disorders. In pediatrics, there is a real need to differentiate Ehlers-Danlos syndrome (EDS) hypermobile type (hEDS) from benign hypermobility, in the absence of a genetic marker specific to this form of EDS. In 2023, the International Ehlers-Danlos Consortium revised the diagnostic criteria for children and adolescents, introducing the concept of hypermobility spectrum disorder.

[Nutrition-obesity. New therapeutic education programme for migrant and allophone people living with obesity].

Migrant and allophone people often face linguistic, cultural and structural barriers, with limited access to healthcare. To address this issue, the Therapeutic Patient Education Unit has created at the University Hospitals of Geneva a new therapeutic programme specifically for these people living with obesity. It includes educational workshops tailored to their language skills, health literacy and migratory background.

[Cardiology. Heart failure, cardiac imaging, congenital heart diseases, and cardio-oncology].

The year 2024 has seen significant progress in the management of heart failure. New treatments have demonstrated their efficacy, particularly for heart failure with preserved ejection fraction, cardiac amyloidosis, and hypertrophic cardiomyopathy. Advances in imaging, such as MRI and PET-CT, highlight the growing integration of innovative technologies and artificial intelligence in cardiology for diagnosing complex cardiovascular diseases.

[Addiction : what's new in 2024].

Addiction medicine is confronting challenges brought about by changes in our modern world, including shifts in the drug market and the increasing digitalization of our environments. This article highlights some of these challenges and explores potential strategies to address them. The field is also advancing through robust research momentum in psychedelic-assisted psychotherapy.

[Physical activity and mental health : the role of psychiatric supervision].

Regular physical activity plays a crucial role in the prevention of chronic disease and the management of mental health disorders. Its integration into the care of individuals with mental health issues is fully justified, with clear benefits to involving trained physical activity professionals. The complexity associated with behavior change processes and the diversity of individuals' situations require specific skills that can be enhanced by the supervision of a psychiatrist.

[Perspectives in internal medicine].

Through the analysis of notable studies from 2024, this article offers an overview of key advances in internal medicine with a selection of essential themes. The topics covered include advances in common internal medicine conditions such as cardiovascular diseases, pulmonary disorders, antibiotic use, and fever of unknown origin. This article provides a practical summary to help clinicians stay informed about the latest diagnostic and therapeutic developments.

[Updates in promotion of health and prevention in the context of the Geneva landscape].

This article presents the latest recommendations for the promotion of health and prevention. This article is primarily addressed to public health actors and stakeholders. The recommendations are contextualized to the local reality, based on Geneva-specific data from the longitudinal Specchio studywhich evaluates the health status of the Geneva population and its determinants.

[The year 2024 placed in perspective by hospital internists].

This article presents a selection of ten key topics, carefully analyzed and commented on by chief residents at the Department of Internal Medicine at CHUV. This curated selection highlights the major advances and essential reminders in internal medicine for 2024. By reviewing this year's leading publications, it sheds light on progress in diagnostic and therapeutic approaches, both for hospitalized patients and the continuity of care in outpatient settings.

[2024 scientific breakthroughs in ambulatory general internal medicine].

In this article, we present eight studies published in the past two years that are likely to influence general practice in 2025. The key messages highlight the importance of physical activity in reducing cardiovascular risk, the effectiveness of aripiprazole for treatment-resistant depression, and the positive impact of guidelines on antibiotic use for acute cystitis. Furthermore, teleconsultation is more effective when supported by a pre-existing therapeutic relationship, extended leave reduces physician burnout, electronic cigarettes aid smoking cessation, and AI improves the management of electronic communications.

A human metabolic map of pharmacological perturbations reveals drug modes of action.

Understanding a small molecule's mode of action (MoA) is essential to guide the selection, optimization and clinical development of lead compounds. In this study, we used high-throughput non-targeted metabolomics to profile changes in 2,269 putative metabolites induced by 1,520 drugs in A549 lung cancer cells. Although only 26% of the drugs inhibited cell growth, 86% caused intracellular metabolic changes, which were largely conserved in two additional cancer cell lines.

The Rare Entity of Basaloid Thymic Carcinoma: A Multicentric Retrospective Analysis from the Italian Collaborative Group for ThYmic MalignanciEs (TYME).

Background: thymic basaloid carcinoma (BTC) is an extremely rare tumor, and very little data are available on BTC's biology, clinical behavior, drug sensitivity, and patient outcomes.

Methods: We performed a retrospective observational study on patients diagnosed with BTC in 11 referral centers of TYME. All BTC diagnoses were reviewed by the referring pathologist.

Controlling the stability of monodisperse phospholipid-coated microbubbles by tuning their buckling pressure.

Hypothesis: Monodisperse phospholipid-coated microbubbles, with a size and resonance frequency tuned to the ultrasound driving frequency, have strong potential to enhance sensitivity, efficiency, and control in emerging diagnostic and therapeutic applications involving bubbles and ultrasound. A key requirement is that they retain their gas volume and shell material during physiologic pressure changes and withstand the overpressure during intravenous injection. The shell typically comprises a mixture of a phospholipid (e.