Uncoupling cell division and cytokinesis during germline development in metazoans.

The canonical eukaryotic cell cycle ends with cytokinesis, which physically divides the mother cell in two and allows the cycle to resume in the newly individualized daughter cells. However, during germline development in nearly all metazoans, dividing germ cells undergo incomplete cytokinesis and germ cells stay connected by intercellular bridges which allow the exchange of cytoplasm and organelles between cells. The near ubiquity of incomplete cytokinesis in animal germ lines suggests that this is an ancient feature that is fundamental for the development and function of this tissue.

The relationship between zooplankton vertical distribution and the concentration of aqueous Hg in boreal lakes: A comparative field study.

The production of the highly toxic monomethylmercury (MeHg) is heterogenous throughout the water column. Multiple factors have been identified to significantly affect this process, such as an extended anoxic water layer and a deep-water phytoplankton maximum. However, the role of water column heterogeneity on mercury (Hg) cycling is still poorly known, especially concerning the role of zooplankton grazers.

Synthesis & Evaluation of Novel Mannosylated Neoglycolipids for Liposomal Delivery System Applications.

Glycosylated NPs, including liposomes, are known to target various receptors involved in cellular carbohydrate transport, of which the mannoside binding receptors are attracting particular attention for their expression on various immune cells, cancers, and cells involved in maintaining central nervous system (CNS) integrity. As part of our interest in NP drug delivery, mannosylated glycoliposomal delivery systems formed from the self-assembly of amphiphilic neoglycolipids were developed, with a C-alkyl mannopyranoside (ML-C) being identified as a lead compoundcapable of entrapping, protecting, and improving the delivery of structurally diverse payloads. However, ML-C was not without limitations in both the synthesis of the glycolipids, and the physicochemical properties of the resulting glycoliposomes.

Anthocyanins Formulated with Carboxymethyl Starch for Gastric and Intestinal Delivery.

Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix.

Synthesis, Characterization, and Swelling Properties of a New Highly Absorbent Hydrogel Based on Carboxymethyl Guar Gum Reinforced with Bentonite and Silica Particles for Disposable Hygiene Products.

Superabsorbent polymers derived from petroleum have been widely used as the primary component of high-water-absorption disposable sanitary products. However, environmental concerns as well as unstable market prices influence the quality of disposable hygiene products. The development of superabsorbent polymers from natural, non-petroleum-derived materials has become more predominant.

Nature and perceived benefits of patient-initiated consultations in community pharmacies: A population survey.

Background: The role of community pharmacists in enhancing patient care has received increased attention. However, there is a paucity of literature on the nature, frequency, and perceived impacts of patient-initiated consultations in community pharmacies.

Objectives: We aim to describe the profile of patients seeking advice from community pharmacists as well as the nature and impact of those consultations.

On integrating patient appointment grids and technologist schedules in a radiology center.

Optimal patient appointment grid scheduling improves medical center performance and reduces pressure from excess demand. Appointment scheduling efficiency depends on resource management, and staff are a key resource. Personnel scheduling takes into account union rules, skills, contract types, training, leave, illness, etc.

Do physical therapists follow evidence-based practices for treatment of inflammatory arthritis? Results from an online survey.

Background: Physical therapists (PTs) should know how to best treat patients with inflammatory arthritis.

Objective: To document interventions chosen by PTs for patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and whether choices follow evidence-based practice.

Methods: Licensed musculoskeletal PTs in Quebec, Canada responded to an online survey.

Characterization of vanillin carbon isotope delta reference materials.

Stable carbon isotope ratio measurements are used to investigate the provenance of vanillin. In this study, a variety of commercial vanillin samples and vanilla products were analyzed to provide a frame of reference for the variability of carbon isotope delta values in various vanillin samples, with the results ranging from -20.6 to -36.

How Work-Family Guilt, Involvement with Children and Spouse's Support Influence Parents' Life Satisfaction in a Context of Work-Family Conflict.

Work-family guilt (WFG) is sometimes perceived as an adaptive characteristic, since it has been found to encourage working parents to engage in more activities with their children in off-work time (Cho & Allen, 2012). However, while it may be an adaptive characteristic for the parent-child relationship, the same may not be true for parents' psychological health. Using insights from the work-home resources model (W-HR), this study aims to determine WFG's influence on parents' life satisfaction.

Agriculture specialization influence on nutrient use efficiency and fluxes in the St. Lawrence Basin over the 20th century.

Increasing the overall use efficiency of nitrogen (N) and phosphorus (P) resources in food production while minimizing losses to the environment are required to meet the dual challenge of food security and sustainability. Yet studies quantifying the overall performance of different agro-system types and how these have changed over time remain rare, although they are essential to propose solution pathways. Here, we reconstructed fluxes of N and P within 78 watersheds of the St.

Long COVID symptoms in a population-based sample of persons discharged home from hospital.

Objectives: The impact of long COVID among persons hospitalized and discharged home is unknown. We aimed to (1) report the prevalence of long COVID in persons hospitalized for COVID-19 and discharged home; (2) estimate the prevalence of physical, sensory, and psychological/mental health impairments; and (3) explore associated factors.

Methods: We conducted a telephone survey of adult residents in Laval, Quebec, who were discharged home ≥ 2 months post-hospitalization for COVID-19.

Electronic Signature of Subnanometer Interfacial Broadening in Heterostructures.

Interfaces are ubiquitous in semiconductor low-dimensional systems used in electronics, photonics, and quantum computing. Understanding their atomic-level properties has thus been crucial to controlling the basic behavior of heterostructures and optimizing the device performance. Herein, we demonstrate that subnanometer interfacial broadening in heterostructures induces localized energy states.

Proximate Drivers of Population-Level Lizard Gut Microbial Diversity: Impacts of Diet, Insularity, and Local Environment.

Diet has been suggested to be an important driver of variation in microbiota composition in mammals. However, whether this is a more general phenomenon and how fast changes in gut microbiota occur with changes in diet remains poorly understood. Forty-nine years ago, ten lizards of the species were taken from the island of Pod Kopište and introduced onto the island of Pod Mrčaru (Croatia).

Evaluation of the Carbon Sink Capacity of the Proposed Kunlun Mountain National Park.

National parks, as an important type of nature protected areas, are the cornerstone that can effectively maintain biodiversity and mitigate global climate change. At present, China is making every effort to build a nature-protection system, with national parks as the main body, and this approach considers China's urgent goals of obtaining carbon neutrality and mitigating climate change. It is of great significance to the national carbon-neutralization strategy to accurately predict the carbon sink capacity of national park ecosystems under the background of global change.

Integrated self-management support provided by primary care nurses to persons with chronic diseases and common mental disorders: a scoping review.

Aim: To map integrated and non-integrated self-management support interventions provided by primary care nurses to persons with chronic diseases and common mental disorders and describe their characteristics.

Design: A scoping review.

Data Sources: In April 2020, we conducted searches in several databases (Academic Research Complete, AMED, CINAHL, ERIC, MEDLINE, PsycINFO, Scopus, Emcare, HealthSTAR, Proquest Central) using self-management support, nurse, primary care and their related terms.

Do anti-HIV drugs pose a threat to photosynthetic microorganisms?

We investigated the occurrence and risk assessment of three anti-HIV drugs [(tenofovir (TNF), lamivudine (LMV) and efavirenz (EFV)] in urban rivers from Curitiba (Brazil), as well as the individual and combined effects of their environmental representative concentrations on the freshwater periphytic species Synechococcus elongatus (Cyanobacteria) and Chlorococcum infusionum (Chlorophyta). The three studied drugs, except TNF, were found in 100% of the samples, and concentrations in samples ranged from 165 to 412 ng TNF L, 173-874 ng LMV L and 13-1250 ng EFV L. Bioassays using artificial contaminated water showed that at environmental concentrations, TNF and LMV did not represent environmental risks to the studied photosynthetic organisms.

Views of Canadian healthcare professionals on the future uses of non-invasive prenatal testing: a mixed method study.

Non-invasive prenatal testing's (NIPT) potential to screen for a wide range of conditions is receiving growing attention. This study explores Canadian healthcare professionals' perceptions towards NIPT's current and possible future uses, including paternity testing, sex determination, and fetal whole genome sequencing. Semi-structured interviews were conducted with ten healthcare professionals, and another 184 participated in a survey.

Nonlinear thermal lensing of high repetition rate ultrafast laser light in plasmonic nano-colloids.

We report on experimental observations of phenomenological self-trapping in plasmonic colloids of varying plasmon peaks in the visible/near infrared. A femtosecond (fs) oscillator is used in both pulsed (35 fs, 76 MHz) and continuous wave (cw) operation for comparison. We show that for both modes and for all examined colloids (and under typically applied external focusing conditions in self-trapping studies in colloidal media) nonlinear propagation is governed by thermal defocusing of the focused beam, which precedes the steady-state regime reached by particle diffusion, even far from the plasmon resonance (or equivalently for non-plasmonic colloids, even for low absorption coefficients).

Deep ocean microbial communities produce more stable dissolved organic matter through the succession of rare prokaryotes.

The microbial carbon pump (MCP) hypothesis suggests that successive transformation of labile dissolved organic carbon (DOC) by prokaryotes produces refractory DOC (RDOC) and contributes to the long-term stability of the deep ocean DOC reservoir. We tested the MCP by exposing surface water from a deep convective region of the ocean to epipelagic, mesopelagic, and bathypelagic prokaryotic communities and tracked changes in dissolved organic matter concentration, composition, and prokaryotic taxa over time. Prokaryotic taxa from the deep ocean were more efficient at consuming DOC and producing RDOC as evidenced by greater abundance of highly oxygenated molecules and fluorescent components associated with recalcitrant molecules.

Synthesis of Deoxyaspidodispermine Based on a Functional Protecting Group Strategy.

A synthesis of deoxyaspidodispermine was produced from homotyramine. This approach is based on the application of a functional protecting group strategy that not only masks the reactivity of sensitive groups during crucial steps but also possesses a moiety desired in the final target, which is transferred to the substrate at the time of deprotection. This synthesis highlights an aza-Michael-Smiles ring-closure cascade, which enables the formation of a tetracyclic system from a nosylamide protecting group.

Integrating major agricultural practices into the TRIPLEX-GHG model v2.0 for simulating global cropland nitrous oxide emissions: Development, sensitivity analysis and site evaluation.

Nitrous oxide (NO) emissions from croplands are one of the most important greenhouse gas sources while the estimation of which remains large uncertainties globally. To simulate NO emissions from global croplands, the process-based TRIPLEX-GHG model v2.0 was improved by coupling the major agricultural activities.

The Importance of Energy Theory in Shaping Elevational Species Richness Patterns in Plants.

Many hypotheses have been proposed to explain elevational species richness patterns; however, evaluating their importance remains a challenge, as mountains that are nested within different biogeographic regions have different environmental attributes. Here, we conducted a comparative study for trees, shrubs, herbs, and ferns along the same elevational gradient for 22 mountains worldwide, examining the performance of hypotheses of energy, tolerance, climatic variability, and spatial area to explain the elevational species richness patterns for each plant group. Results show that for trees and shrubs, energy-related factors exhibit greater explanatory power than other factors, whereas the factors that are associated with climatic variability performed better in explaining the elevational species richness patterns of herbs and ferns.

Planning for resilience in screening operations using discrete event simulation modeling: example of HPV testing in Peru.

Background: The World Health Organization (WHO) has called for the elimination of cervical cancer. Unfortunately, the implementation of cost-effective prevention and control strategies has faced significant barriers, such as insufficient guidance on best practices for resource and operations planning. Therefore, we demonstrate the value of discrete event simulation (DES) in implementation science research and practice, particularly to support the programmatic and operational planning for sustainable and resilient delivery of healthcare interventions.