318 results match your criteria: "Subcutaneous Fat Necrosis of the Newborn"
Visseral Lipectomy Improves Metabolic Syndrome Parameters and Adipokines in a Rat Model of Metabolic Syndrome Induced by Monosodium Glutamate.
Aesthetic Plast Surg
November 2024
Medical Faculty Department of Physiology, Pamukkale University, Denizli, Turkey.
Objective: Metabolic syndrome (MetS) includes abdominal obesity, hypertension, insulin resistance, and dyslipidemia. Research has indicated that reducing excess visceral fat has positive effects on inflammation and insulin resistance. We examined whether visceral lipectomy modifies the effects of MetS parameters and adipocytokine levels.
View Article and Find Full Text PDFA Hypercalcemic Crisis Complicating Subcutaneous Fat Necrosis of the Newborn: A Case Report and Literature Review.
Cureus
July 2024
Pediatric Nephrology, Mansoura University Children Hospital, Mansoura, EGY.
Article Synopsis
- Subcutaneous fat necrosis of the newborn (SFNN) is a rare skin condition that results in skin nodules and usually resolves on its own, but requires careful monitoring for complications like hypercalcemia.* -
- A case study described a male newborn who had two NICU admissions for hypoglycemia and sepsis, where reddish nodules appeared, leading to further health issues like hypercalcemia and eosinophilia.* -
- The infant developed complications including nephrocalcinosis and deep venous thrombosis, underscoring the need for ongoing observation of SFNN to identify any emerging health risks.*
Subcutaneous fat necrosis of the newborn with fluctuant nodules mimicking infection.
JAAD Case Rep
June 2024
Department of Dermatology, UMass Chan Medical School, Worcester, Massachusetts.
Congenital liquified subcutaneous fat necrosis in a newborn: an unusual case.
Dermatol Online J
March 2024
Department of Neonatology, Hedi Chaker University Hospital, Sfax University, Sfax, Tunisia University of Medicine of Sfax, Sfax, Tunisia.
Article Synopsis
- Subcutaneous fat necrosis of the newborn is a temporary condition occurring within the first six weeks of life, requiring careful monitoring for complications, particularly hypercalcemia.
- Diagnosis can be tricky as it may resemble other conditions like bacterial cellulitis or erysipelas, which necessitates thorough clinical, biological, and histological evaluations.
- In the reported case, a full-term newborn required a surgical incision due to discomfort and persistent symptoms, after which complications like hypercalcemia and nephrocalcinosis developed, highlighting the importance of follow-up care.
Subcutaneous fat necrosis of the newborn: A systematic review of surgical management and outcomes.
J Plast Reconstr Aesthet Surg
April 2024
Division of Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:
Article Synopsis
- Subcutaneous fat necrosis of the newborn (SCFN) is a rare condition in neonates characterized by red plaques or nodules and may require surgical intervention in severe cases; however, there's limited literature on surgical outcomes.
- A systematic review identified 16 patients from 22 studies who underwent surgical management for SCFN, with the average age of diagnosis being about 12 days and surgery at around 40 days; common lesion locations were the back and limbs.
- The study found that conditions like therapeutic hypothermia were significant causes of SCFN, and more case reporting is needed to better understand surgical management and outcomes for affected patients.
Therapeutic hypothermia for preterm infants 34-35 weeks gestational age with neonatal encephalopathy.
J Perinatol
April 2024
Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- - The study aimed to assess the effectiveness and safety of therapeutic hypothermia (TH) for treating neonatal encephalopathy in preterm infants born at 34-35 weeks of gestation.
- - Researchers conducted a matched retrospective study comparing outcomes of 20 preterm infants (34-35 weeks) receiving TH with 40 infants (36 weeks or more) over a period from 2015 to 2021.
- - Results showed that short-term outcomes were similar between the two groups, indicating that TH is a feasible and safe option for preterm infants at 34-35 weeks of gestation.
Subcutaneous fat necrosis of the newborn: a skin manifestation of perinatal stress.
BMJ Case Rep
January 2024
Pediatric Department, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal.
Subcutaneous Fat Necrosis of the Newborn After Whole-Body Cooling for Birth Asphyxia.
Cureus
February 2023
Pediatrics, Al Qassimi Women's and Children's Hospital, Sharjah, ARE.
Article Synopsis
- * Despite its benefits, TH can lead to serious side effects, including a rare condition known as subcutaneous fat necrosis (SCFN).
- * The case report focuses on a newborn who developed SCFN following whole-body cooling, highlighting potential complications associated with this treatment.
Subcutaneous fat necrosis of the newborn: A retrospective study of 32 infants and care algorithm.
Pediatr Dermatol
May 2023
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Article Synopsis
- The study focused on infants diagnosed with subcutaneous fat necrosis of the newborn (SCFN) at a children's hospital over a 10-year period, analyzing clinical and lab outcomes.
- Among the 32 infants, hypercalcemia was found in all cases, with some developing serious complications, including kidney issues, primarily within the first month of life.
- The findings suggest initial and ongoing monitoring of ionized calcium levels in SCFN cases, with specific care recommendations for infants exhibiting severe or prolonged hypercalcemia.
Subcutaneous fat necrosis in newborns: a systematic literature review of case reports and model of pathophysiology.
Mol Cell Pediatr
November 2022
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
Article Synopsis
- Subcutaneous fat necrosis of the newborn (SCFN) is a rare condition that manifests as purple or red nodules on an infant’s skin, usually self-resolving within 6 months but may lead to severe hypercalcaemia.
- A systematic review compiled data from 206 publications, analyzing 320 case reports to classify calcium levels and identify potential risk factors associated with SCFN.
- Findings revealed that most cases had hypercalcaemia, often linked to maternal conditions like gestational diabetes and delivery complications; nearly all cases showed granulomatous inflammation, indicating these factors should be considered in neonatal care.
Rapid cytologic diagnosis of subcutaneous fat necrosis of the newborn.
Pediatr Dermatol
March 2023
Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Article Synopsis
- - Subcutaneous fat necrosis of the newborn is a rare condition that shows up in infants during their first few weeks and is characterized by inflammation of the fat tissue.
- - The usual way to diagnose it is through clinical evaluation, but sometimes a skin biopsy is needed, which uses special stains to confirm the diagnosis.
- - A new, quicker diagnostic method has been developed that involves examining a small sample from a lesion under a microscope, revealing distinct crystals that indicate subcutaneous fat necrosis, making the process easier and more accessible in resource-limited environments.
Subcutaneous fat necrosis of the newborn: a pictorial essay of an under-recognized entity.
Pediatr Radiol
February 2023
Department of Radiology, Columbia University Medical Center, 622 West 168th St., New York, NY, 10032, USA.
Article Synopsis
- * This condition is often linked to complications like perinatal asphyxia and can manifest as dermal edema followed by skin discoloration.
- * Diagnosis typically relies on physical examination, but ultrasound (US) is recommended for confirmation due to its effectiveness in evaluating superficial lesions without the risks of radiation.
Subcutaneous Fat Necrosis of Newborn: An Atypical Presentation.
Indian J Dermatol
January 2022
Department of Paediatrics, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, Maharashtra, India E-mail:
Safety and Efficacy of Pamidronate in Neonatal Hypercalcemia Caused by Subcutaneous Fat Necrosis: A Case Report.
Front Pediatr
April 2022
Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Article Synopsis
- * Standard treatments for SCFN include hydration, furosemide, and corticosteroids, but these can have side effects and may need to be extended over several days.
- * This study presents a case where severe hypercalcemia related to SCFN was effectively treated with a single dose of pamidronate after initial therapies, suggesting bisphosphonates might be a valuable alternative for managing this condition.
Subcutaneous Fat Necrosis of the Newborn.
JAMA Dermatol
July 2022
Department of Dermatology and Allergology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
[Effects of Xiangqin Jiere Granules on lipid metabolism and chronic inflammation in different obesity model mice].
Zhongguo Zhong Yao Za Zhi
March 2022
Yunnan University of Chinese Medicine Kunming 650500, China Yunnan Key Laboratory of Applied Drug Delivery System and Preparation Technology Kunming 650500, China.
Article Synopsis
- This paper investigates the impact of Xiangqin Jiere Granules (XQ) on lipid metabolism and chronic inflammation in mice models for obesity created by either MSG injection or a high-fat diet.
- The study involved categorizing mice into control and model groups, with varying doses of XQ administered for 5 weeks, followed by assessments of body weight, fat mass, and lipid levels.
- Results showed that XQ treatment reduced body weight and fat levels compared to MSG and HFD mice, which had increased inflammation markers and lipid metabolic gene expressions.
NEMO-NDAS: A Panniculitis in the Young Representing an Autoinflammatory Disorder in Disguise.
Am J Dermatopathol
June 2022
Department of Pathology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Article Synopsis
- A 15-month-old boy with sickle cell trait developed widespread skin nodules since 2 weeks old, which later led to lipoatrophy and hyperpigmentation and was misdiagnosed as newborn fat necrosis.
- By 4 months, he exhibited systemic inflammatory symptoms, prompting further testing that revealed significant blood abnormalities and a new skin biopsy indicating neutrophilic lobular panniculitis.
- Whole-exome sequencing initially showed no mutations, but later reanalysis identified a mutation linked to NEMO Δ-exon 5-autoinflammatory syndrome, highlighting the need for careful diagnosis of autoinflammatory disorders in young children using advanced genetic techniques.
Subcutaneous Fat Necrosis of the Newborn.
Skinmed
January 2022
Department of Dermatology, University of Medicine of Monastir, Monastir, Tunisia.
Article Synopsis
- - A newborn boy weighing 4500g was delivered via C-section at 41 weeks due to fetal distress, shortly after which he exhibited respiratory issues and required ventilation support, followed by convulsions diagnosed as hypoxic-ischemic encephalopathy.
- - Subsequent examination revealed firm, nodular lesions on his body, diagnosed as subcutaneous fat necrosis, accompanied by laboratory results indicating low levels of calcium, magnesium, and potassium.
- - Treatment involved vitamin and electrolyte supplementation, which led to improved calcium levels, but resulted in hypertriglyceridemia; after managing complications with medication, the infant showed complete recovery from fat necrosis and normalized growth by the end of two months.
What to Look Out for in a Newborn with Multiple Papulonodular Skin Lesions at Birth.
Dermatopathology (Basel)
August 2021
Department of Dermatology, Necker-Enfants Malades Hospital, APHP, 75015 Paris, France.
Multiple papulonodular skin lesions at birth can indicate the presence of various benign and malignant disorders. Although the lesions' clinical aspect (color and consistency, in particular) may steer the clinician towards one disorder or another (infantile myofibromatosis, xanthogranuloma, or metastatic neuroblastoma), the diagnosis can only be confirmed by the histopathologic assessment of a biopsy. In neonates, a rapid but accurate diagnosis is critical because skin lesions may be the first manifestation of a malignant disorder like leukemia cutis or metastatic neuroblastoma.
View Article and Find Full Text PDFSubcutaneous fat necrosis associated with hypercalcemia in neonates with neonatal encephalopathy treated with therapeutic hypothermia.
Semin Fetal Neonatal Med
August 2021
Department of Neonatology and Intensive Care, University Children's Hospital Zurich, Steinwiesstrasse 37, 8075, Zurich, Switzerland; Children's Research Center, University Children's Hospital Zurich, Steinwiesstrasse 37, 8075, Zurich, Switzerland; University of Zurich, Zurich, Switzerland. Electronic address:
Article Synopsis
- Subcutaneous fat necrosis of the newborn (SFNN) is a rare skin condition that usually appears within the first week of life, often around day 6.
- About 50% of affected infants may develop hypercalcemia within the first month, sometimes linked to abnormal vitamin D processing in necrotic tissue.
- The condition generally resolves on its own with proper monitoring and treatment, which may include specialized diets or intravenous medications, and benefits from a team approach involving various healthcare specialists.
Subcutaneous fat necrosis in an infant with hypoxic ischaemic encephalopathy stage 3: an uncommon association.
BMJ Case Rep
July 2021
Skin and Venereal Diseases, Madhukar Rainbow Children's Hospital, Delhi, India.
Subcutaneous fat necrosis (SCFN) is inflammation and necrosis of adipose tissue associated with hypoxia and hypothermia. It leads to various metabolic abnormalities, of which the most dreaded is hypercalcaemia. We report a case of a 7-week-old boy with history of birth asphyxia (hypoxic ischaemic encephalopathy stage 3) who presented to us with features suggestive of hypercalcaemia with bilateral nephrocalcinosis.
View Article and Find Full Text PDFSubcutaneous fat necrosis in a 14-day-old neonate presenting with multiple ulcers.
Int J Dermatol
January 2022
Dermatology, Southern Philippines Medical Center, Davao City, Davao del Sur, Philippines.
Congenital ulcerated subcutaneous fat necrosis in a newborn - an unusual entity.
Hippokratia
January 2020
First Department of Pediatrics, Aristotle University, Hippokratio Hospital, Thessaloniki, Greece.