1,727 results match your criteria: "Stroke Institute[Affiliation]"

Article Synopsis
  • Renal dysfunction is linked to how quickly brain infarction progresses in patients who have suffered from anterior circulation large vessel occlusion (ACLVO) strokes, a topic not previously explored.
  • A study analyzed data from 230 patients admitted with specific types of occlusions and measured their infarct growth rate (IGR) through imaging, categorizing them into fast or slow progressors based on this rate.
  • Results indicated that those with higher serum creatinine levels and lower eGFR were more likely to be fast progressors and faced worse clinical outcomes and higher mortality rates after 90 days.
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Large inferior vena cava thrombosis in a 25-year-old female patient: A case report.

Medicine (Baltimore)

November 2024

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.

Rationale: The incidence of venous thromboembolism is increasing, and it is more common in older than in younger patients. Inferior vena cava (IVC) thrombosis is a rare subtype of deep vein thrombosis, and it is associated with a high incidence of arterial and venous thrombosis in patients with systemic lupus erythematosus (SLE). We present the case of a 25-year-old female patient with a large IVC thrombosis caused by SLE that was intractable to thrombolytic therapy.

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Background: Vascular complications are common and can be fatal even after successful decannulation in patients with peripherally cannulated veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Therefore, we aimed to accurately determine the incidence of arterial complications assessed by Duplex ultrasound following peripheral VA-ECMO decannulation. In addition, we investigated the predictors of severe complications requiring intervention.

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Clinical Impact of Sarcopenia Screening on Long-Term Mortality in Patients Undergoing Coronary Bypass Grafting.

J Cachexia Sarcopenia Muscle

December 2024

Department of Thoracic and Cardiovascular Surgery, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: Sarcopenia is an aging-related condition characterized by loss of skeletal muscle mass and is an indicator of subclinical atherosclerosis. The relationship between reduced muscle mass and long-term clinical outcomes in patients with advanced coronary artery disease who have undergone coronary artery bypass grafting (CABG) is not fully understood. This study is sought to evaluate the prognostic implications of sarcopenia screening in patients undergoing CABG.

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Article Synopsis
  • A study evaluated the safety and efficacy of endovascular thrombectomy in patients with acute large-vessel occlusion and tandem lesions, focusing on those with low (0-5) and high (6-10) Alberta Stroke Program Early Computed Tomography Scores (ASPECTS).
  • The analysis included 691 patients, revealing that those with low ASPECTS had significantly lower odds of achieving a favorable functional outcome (mRS 0-2) and higher odds of suffering symptomatic intracranial hemorrhage compared to those with high ASPECTS.
  • The researchers concluded that endovascular thrombectomy may lead to poorer functional recovery in patients with tandem lesions and low ASPECTS, particularly in the
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Article Synopsis
  • The study investigates how the number of mechanical thrombectomy (MT) procedures performed annually at hospitals affects patient outcomes for acute ischemic stroke in the U.S. from 2016 to 2020.
  • It found that as MT procedural volume increases, patients had lower rates of being discharged home/self-cared and higher odds of in-hospital mortality and post-treatment intracranial hemorrhage (ICH).
  • The results suggest a paradox where higher procedural volume at hospitals correlates with worse outcomes, likely due to treating more severe cases at these high-volume centers.
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Background: Intravenous thrombolysis (IVT) is the cornerstone treatment for the acute ischemic stroke (AIS) within 4.5 h after onset. Current guidelines recommend administering antiplatelet medications 24 h after IVT.

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Background: First-pass successful reperfusion (FPSR), defined as a successful/complete reperfusion achieved after a single thrombectomy pass, is predictive of favorable outcome in patients with acute ischemic stroke with large-vessel occlusion. It is unknown whether intravenous tirofiban is effective in increasing the rate of FPSR in acute anterior large-vessel occlusion stroke.

Methods And Results: Patients who had acute large-vessel occlusion stroke presenting within 24 hours and underwent endovascular thrombectomy were analyzed from the RESCUE BT (Intravenous Tirofiban for Patients With Large Vessel Occlusion Stroke) clinical trial, of which the main analysis was neutral.

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Experimental validation of coronary stenosis severity and development of ischemic myocardium.

Rev Esp Cardiol (Engl Ed)

October 2024

Department of Internal Medicine and Cardiovascular Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea. Electronic address:

Introduction And Objectives: The current study aimed to evaluate the causal association between hemodynamically significant stenosis and the occurrence of ischemic myocardium using an experimental animal model of coronary artery stenosis.

Methods: In Yorkshire swine (n = 10), coronary stenosis in the left anterior descending artery was induced using a customized vascular occluder to create varying degrees of occlusion severity (40%-99%). Serial changes in coronary pressure and flow velocity were measured in the left anterior descending artery before and after the implantation of the vascular occluder.

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Interpreting Variations in Fugl-Meyer Assessment Protocols: Results and Recommendations From a Nominal Group Consensus Process.

Arch Phys Med Rehabil

October 2024

Occupational Therapy Department, Byrdine F. Lewis College of Nursing and Health Professions, Georgia State University, Atlanta, GA.

Objective: To identify variations among administration and scoring instructions of 6 upper extremity Fugl-Meyer Assessment (FMA-UE) protocols and to achieve consensus regarding optimal administration procedures.

Design: Nominal group consensus technique comprised of iterative independent reviews of protocol content, anonymous voting, and group consensus meetings.

Setting: Clinicians working in clinical practice and research settings participated in virtual meetings via Zoom.

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Objective: To evaluate the role of endovascular thrombectomy (EVT) in patients presenting with acute ischemic stroke (AIS) due to large vessel occlusion in the very late window (>24 hours).

Methods: A systematic review was conducted according to PRISMA guidelines using PubMed, CINAHL, Scopus, and Google Scholar databases till 2024. Quality assessment was performed using the Newcastle-Ottawa Scale (NOS).

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Background And Purpose: Nutritional status can influence the outcomes and mortality of various diseases. The association between initial nutritional status and ischemic stroke outcomes, however, remains poorly understood. This study investigated whether the Controlling Nutritional Status (CONUT) score at admission could predict functional recovery, complications, and survival following an ischemic stroke.

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Purpose: Contrast enhancement (CE) after mechanical thrombectomy (MT) remains a subject of investigation, with a reported prevalence ranging from 31 to 88%. We examined our patients to identify predictors of CE and its impact on outcomes, an aspect that remains understudied.

Methods: We retrospectively analyzed 106 patients who underwent MT at our hospital between 2018 and 2022.

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Background: Six randomized trials have not detected a difference between intravenous alteplase plus endovascular thrombectomy and endovascular thrombectomy alone in stroke. Tenecteplase, a recombinant human tenecteplase tissue-type plasminogen activator, is a genetically modified variant of alteplase. It is unclear whether the outcomes are different if alteplase is replaced with tenecteplase.

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Many countries have published clinical practice guidelines for appropriate clinical decisions, optimal treatment, and improved clinical outcomes in patients with acute coronary syndrome. Developing guidelines that are specifically tailored to the Korean environment is crucial, considering the treatment system, available medications and medical devices, racial differences, and level of language communication. In 2017, the Korean Society of Myocardial Infarction established a guideline development committee.

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Introduction: This study aimed to evaluate the diagnostic utility of electroencephalography (EEG) and somatosensory evoked potentials (SSEP) as modalities of intraoperative neurophysiological monitoring (IONM) in predicting postoperative delirium (POD) in patients who underwent carotid endarterectomy (CEA) surgery.

Methods: A total cohort of 425 patients was included in this study. Medical record data were reviewed retrospectively and their documented significant IONM data were analyzed and integrated into the study for each patient.

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Prognosis after switching to electronic cigarettes following percutaneous coronary intervention: a Korean nationwide study.

Eur Heart J

October 2024

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.

Background And Aims: Despite the increasing popularity of electronic cigarettes (E-cigarettes), the prognostic impact of switching to E-cigarettes in smokers with coronary artery disease who have undergone percutaneous coronary intervention (PCI) remains unclear.

Methods: Using a nationwide cohort from the Korean National Health Insurance database, 17 973 adults (≥20 years) identified as smokers (based on a health screening examination within 3 years before PCI) who underwent health screening within 3 years after PCI were enrolled to determine changes in smoking habits. Patients were classified as continued combustible cigarette users, successful quitters, or switchers to E-cigarettes.

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Article Synopsis
  • The study assessed how the quality of reperfusion affects clinical and radiological outcomes in patients from the ESCAPE NA1 trial.
  • Researchers analyzed different reperfusion patterns using the expanded Treatment in Cerebral Infarction (eTICI) Scale to compare patient outcomes, including rates of good or excellent clinical recovery, symptomatic hemorrhage, and death.
  • Results showed that higher reperfusion grades were linked to better clinical outcomes and lower mortality rates, regardless of how many attempts were needed to achieve them, or the speed of reperfusion.
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Nonopacification of Frontal and Parietal Branches After Middle Meningeal Artery Embolization: A Radiographic Benchmark.

World Neurosurg

December 2024

Department of Neurological Surgery, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

Background: Middle meningeal artery embolization (MMAE) has revolutionized the armamentarium for chronic subdural hematoma (CSDH) treatment. Technical and angiographic benchmarks to guide procedural and clinical success are less well established.

Methods: A single-center database was reviewed to compare outcomes after standalone MMAE with and without resultant residual angiographic opacification of frontal and parietal (F/P) branches.

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The Risk and Reversibility of Osimertinib-Related Cardiotoxicity in a Real-World Population.

J Thorac Oncol

October 2024

Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Article Synopsis
  • Osimertinib, a treatment for advanced non-small cell lung cancer, demonstrated a 4.7% incidence of cardiotoxicity in real-world settings, raising concerns about its long-term safety.
  • The study analyzed 1,126 patients and identified risk factors for cardiotoxicity, including older age, previous heart failure, atrial fibrillation, and low left ventricle strain.
  • A high recovery rate of 82.4% for cardiac dysfunction was observed, indicating potential reversibility, but emphasizes the need for careful monitoring in at-risk patients.
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Article Synopsis
  • - The K-REDEFINE study examined Heart Rate Turbulence (HRT) and T-wave alternans (TWA) as potential markers for predicting serious heart conditions in South Korean patients with acute myocardial infarction (MI) or heart failure (HF).
  • - The results showed that abnormal HRT was a strong predictor of adverse cardiac events, including cardiac death and hospitalizations due to heart failure, with a particularly high predictive value when combined with a reduced ejection fraction.
  • - In contrast, abnormal TWA was only associated with the overall risk of cardiac events and did not show as strong a predictive capability as HRT in this study.
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Article Synopsis
  • Hypertrophic cardiomyopathy (HCM) is a condition with different forms and varying risks for sudden cardiac death (SCD), and this study aimed to categorize these forms based on their SCD-related features and outcomes.
  • Researchers analyzed data from 1,231 HCM patients and identified three distinct groups: young patients with low SCD risk (Group 1), young patients with high SCD risk (Group 2), and older patients (Group 3) who faced different rates of SCD and other complications.
  • The findings suggest that using these clear phenotypes can help better assess risks and manage patients with HCM more effectively.
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Ablation therapy following unsuccessful electrical cardioversion in patients with persistent atrial fibrillation.

Sci Rep

October 2024

Division of Cardiology, Department of Internal Medicine, Heart Vascular and Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Article Synopsis
  • - The study compared the effectiveness of non-ablation therapy (medical treatment) and ablation therapy (surgical intervention) in patients with persistent atrial fibrillation (AF) who didn’t respond to electrical cardioversion (ECV) between 2017 and 2023.
  • - Out of 125 patients analyzed, those who underwent ablation therapy showed significantly better AF-free survival rates compared to those on non-ablation therapy, indicating that ablation may be the preferable treatment after unsuccessful ECV.
  • - Predictors of AF recurrence included longer AF duration, lower body mass index (BMI), and the presence of diabetes, but the method of ablation (catheter vs. thoracoscopic) did not significantly affect
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Article Synopsis
  • The study looked at whether a medical procedure called thrombectomy helps patients who have a large stroke as seen on a specific type of scan called a noncontrast CT within 24 hours of having the stroke.
  • It involved 300 patients from different hospitals who were split into two groups; one group received the thrombectomy treatment, while the other only received regular care.
  • The main goal was to see if those who had thrombectomy had better recovery after 90 days compared to those who didn’t, along with checking if there were any serious side effects.
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