Sodium bisulfite boosted exopolysaccharide production by Auxenochlorella protothecoides: Potential mechanisms harnessing HO signaling and carbon reallocation.

Microalgal exopolysaccharides (EPS) possess significant functional benefits across various industrial sectors, but their commercial feasibility is constrained by inefficient synthesis and poorly understood synthesis mechanisms. This study found that 1.25 mmol/L sodium bisulfite promoted EPS accumulation to 224.

What are the levels and interactions of neuroligin-1, neuroligin-3, and inflammatory cytokines (IL-6, IL-8) in children diagnosed with autism spectrum disorder?

Autism spectrum disorder (ASD) is characterized by deficits in social interaction, restricted interests, and repetitive behaviors. Several genes, including synaptic proteins and environmental risk factors, play a role in the etiology of autism. We aimed to evaluate the relationship between neuroligin-1 (NLGN-1) and neuroligin-3 (NLGN-3) levels, which are neuronal cell adhesion molecules (CAMs), and inflammatory cytokine (IL-6, IL-8) levels with disease severity and symptom clusters and with each other in children with ASD.

Regulatory networks of bZIPs in drought, salt and cold stress response and signaling.

Abiotic stresses adversely impact plants survival and growth, which in turn affect plants especially crop yields worldwide. To cope with these stresses, plant responses depend on the activation of molecular networks cascades, including stress perception, signal transduction, and the expression of specific stress-related genes. Plant bZIP (basic leucine zipper) transcription factors are important regulators that respond to diverse abiotic stresses.

Bone Stress Injury Epidemiology and Risk Factors in Female Off-Road Runners: A Systematic Review.

Background: Off-road running is a growing sport with little research investigating injury profiles of female participants. Bone stress injuries (BSIs) are a particularly detrimental injury with little known about their incidence and risk factors in female off-road runners.

Objective: Collate and review the available evidence reporting epidemiological data and risk factors associated with BSI in female off-road runners.

Norharmane prevents muscle aging via activation of SKN-1/NRF2 stress response pathways.

Sarcopenia, the age-related decline in muscle mass and function, is a significant contributor to increased frailty and mortality in the elderly. Currently, no FDA-approved treatment exists for sarcopenia. Here, we identified norharmane (NR), a β-carboline alkaloid, as a potential therapeutic agent for mitigating muscle aging.

Crocin facilitates osteogenesis and angiogenesis by moderating oxidative stress and ferroptosis via Nrf2/GPX4 pathway.

Bone formation is a complex multi-factor process of bone defect healing. Oxidative stress (OS) is predisposed to induce regulatory cell death (RCD), such as ferroptosis. At present, the antioxidant effects of Crocin on erastin induced oxidative damage were studied.

Exploring the mechanisms of cadmium tolerance and bioaccumulation in a soil amoeba.

Cadmium (Cd) pollution is a global concern. Protists represent a prevalent yet understudied group in soil ecosystems, but our understanding of how protists interact with Cd remains limited. This study investigates the interaction between Cd and the soil amoeba Dictyostelium discoideum, focusing on its resistance, accumulation, and molecular mechanisms.

Enhanced virulence of Acinetobacter johnsonii at low temperatures induces acute immune response and systemic infection in American bullfrogs (Aquarana catesbeiana).

Acinetobacter johnsonii is a denitrifying bacterium commonly used as an environmental probiotic in wastewater treatment. However, research on its potential pathogenicity to animals is limited. During an epidemiological survey conducted from 2022 to 2024 at bullfrog farms in Guangdong Province, China, multiple strains were isolated from diseased bullfrogs during the low-temperature season.

Novel bioactive peptides alleviate Western diet-induced MAFLD in C57BL/6J mice by inhibiting NLRP3 inflammasome activation and pyroptosis via TLR4/NF-κB and Keap1/Nrf2/HO-1 signaling pathways.

Metabolic-associated fatty liver disease (MAFLD) has emerged as a leading chronic liver disease. This condition is characterized by an abnormal accumulation of fat within liver and can progress from simple steatosis to more severe stages involving chronic inflammation and oxidative stress. In this study, we investigated the potential therapeutic effects and underlying mechanism of novel bioactive peptides (EWYF and EWFY) on Western diet-induced MAFLD in C57BL/6J mice.

Non-comparability and unplannability as material topoi in antenatal care conversations.

Objective: This paper studies argumentation and its function to establish common ground in pregnancy counseling conversations during the third trimester of the pregnancy, focusing on two material topoi: Non-comparability and Unplannability.

Methods: We take a conversation-analytical and interactional approach and draw on 37 natural occurring counseling conversations, videorecorded during two periods at a university hospital. The conversations are typically between the midwife and the pregnant woman.

Sleep health among sexual and gender minority people in the United States: A scoping review.

Sleep has been found to be essential to physical and mental health. Sexual and gender minority (SGM; e.g.

Association of Murray's law with atherosclerosis risk: Numerical validation of a general scaling law of arterial tree.

Atherogenesis is prone in medium and large-sized vessels, such as the aorta and coronary arteries, where hemodynamic stress is critical. Low and oscillatory wall shear stress contributes significantly to endothelial dysfunction and inflammation. Murray's law minimizes energy expenditure in vascular networks and applies to small arteries.

Ascorbic acid and resveratrol improve the structural integrity of the extracellular matrix and enhance follicular survival in cultured bovine ovarian tissue.

This study aimed to investigate the changes induced by the culture system and the effect of ascorbic acid and resveratrol on collagen fibers, stromal cells, follicle growth and survival, as well as antioxidant enzyme activity in cultured bovine ovarian tissues. In experiment 1, bovine ovarian fragments were cultured in α-minimum essential medium (α-MEM) for 6 days. Before and after culturing, the fragments were fixed and processed to assess follicular morphology and diameters, stromal cell survival, collagen fibers, and glycosaminoglycans (GAGs).

Mitigative effects of didymin against cadmium-induced renal injury via regulating Nrf-2/Keap-1, apoptosis, inflammation and oxidative stress.

Background: Cadmium (Cd) is a toxic heavy metal present in environment that has potential to instigate renal toxicity. Didymin (DDM) is a natural flavone, which shows anti-oxidant, anti-inflammatory and antiapoptotic nature. Therefore, the current study was formulated to appraise attenuative potential of DDM against Cd instigated nephrotoxicity.

Microbial metabolism in wormcast affected the perturbation on soil organic matter by microplastics under decabromodiphenyl ethane stress.

Large-scale plastic wastes annually inevitably induce co-pollution of microplastics (MPs) and novel brominated flame retardants (NBFRs), while gaps remain concerning their effect on terrestrial function. We investigated the impact of polylactic acid (PLA) or polyethylene (PE) MPs after aging in soil-earthworm microcosms under decabromodiphenyl ethane (DBDPE) contamination. MPs altered the food (i.

The inhibition of anammox system under Cu stress and mechanisms of biochar-mediated recovery.

Copper (Cu)-containing wastewater has proven difficult to effectively treat using the anammox process. In this study, the nitrogen removal efficiency (NRE), sludge characteristics, microbial community and recovery mechanisms of biochar-mediated anammox under Cu stress were elucidated. At a Custress of 5 mg/L, a 73.

Advancing burn wound healing with an innovative in situ gelling probiotic microparticle formulation employing quality by design (QbD) principles.

Scientists investigated probiotic-containing dressings to address the challenges associated with burn injuries, namely infection and antimicrobial resistance. The present investigation sought to evaluate the impact of innovative probiotic-loaded microparticles with in situ gelling characteristics on infected burns. The strain, Lactiplantibacillus plantarum, was selected due to its demonstrated wound-healing potential.

What makes a trauma 'pathological'? - Perceived peritraumatic threat influences the development of intrusive memories.

Intrusions are a hallmark symptom of posttraumatic stress disorder (PTSD). While dysfunctional cognitions are known posttraumatic contributors, peritraumatic processes are less understood. Perceived threat, alongside emotional factors, is theorized as significant, but experimental studies are lacking.

New insights into persistent corneal subepithelial infiltrates following epidemic keratoconjunctivitis: The first case report with ultrastructural and immunohistochemical investigations.

Epidemic keratoconjunctivitis (EKC) is one of the most severe clinical manifestations of human adenovirus ocular surface infection, which may lead to the formation of subepithelial infiltrates (SEIs) in the anterior corneal stroma in 20-50 % of cases. SEIs may be asymptomatic or give rise to corneal aberrations and visual impairment for months or years after acute infection, despite treatments. Here, we describe the ultrastructural and immunophenotypic features of the anterior corneal stroma of a patient who underwent superficial anterior lamellar keratoplasty (SALK) surgery to remove corneal opacities related to clinically significant and steroid-unresponsive, long-lasting SEIs after adenoviral EKC.

Healthcare professionals' attitudes to animal assisted activity with dogs in paediatric care.

Background: Hospitalization for children often involves stress induced by fear and pain. Complementary therapies, such as Animal Assisted Activities (AAA) with dogs, can alleviate the hospital experience.

Purpose: The first aim of this study was to initiate the development of an instrument that measures healthcare professionals' attitudes toward complementary therapy, specifically dogs in AAA.

Involuntary autobiographical memories as a transdiagnostic factor in mental disorders.

Involuntary autobiographical memories are memories of personal events that come to mind with no preceding retrieval attempts. They have been studied broadly in autobiographical memory for decades and shown to be common and mostly positive in everyday life. Clinical literature has focused on negative intrusive memories of stressful events and tended to neglect other forms of involuntary autobiographical memories.

A transplantation study in the high-altitude ecosystem of Ladakh suggests site-specific microenvironment is key for physiological adaptation than altitude.

Transplantation experiments conducted in high altitude ecosystems are rising as key strategy to examine the response of individual plant transplanted across distinct elevations. However, plant physiological and biochemical performance in response to changes in abiotic factors across different species and mountain ranges is still lacking. So in the present study, we have made an attempt to link the physiological performance with that of altitudinal gradient in Ladakh by transplanting Lepidium latifolium at four different altitudinal sites.

Mind relaxation effect of Jatamansi Taila Shirodhara on psychological distress in Triple Negative Breast Cancer (TNBC) patients - results of an open-labelled, randomised controlled clinical trial.

Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer clinically defined as lacking expression of Estrogen receptor (ER), Progesterone receptor (PR), and Human Epidermal growth factor Receptor (HER2). Psychological distress is a major risk factor of TNBC, patients diagnosed with TNBC are under tremendous stress due to the aggressive nature of the disease. Stress hormones decrease the efficacy of therapeutics.

Maternal postpartum depression and children's emotional overeating: The mediating role of executive function.

Objectives: The literature shows connections between maternal depression, children's executive function (EF), and emotional overeating (EOE). This study examined the interplay between maternal postpartum depression, EF, and EOE. We hypothesized that higher levels of postpartum depression would lead to lower inhibition and emotional control and higher levels of EOE.