14,209 results match your criteria: "Streptococcus Group A Infections"

Group A ß-hemolytic Streptococcus (S. pyogenes), also known as GAS, is a Gram-positive bacterium. It can be easily identified in the microbiology laboratory by its ability to hemolyse blood in culture media.

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The role of meteorological factors, such as rainfall or temperature, as key players in the transmission and survival of infectious agents is poorly understood. The aim of this study was to compare meteorological surveillance data with epidemiological surveillance data in Belgium and to investigate the association between intense weather events and the occurrence of infectious diseases. Meteorological data were aggregated per Belgian province to obtain weekly average temperatures and rainfall per province and categorized according to the distribution of the variables.

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Loratadine Derivative Lo-7: A Weapon against Drug-Resistant and Infections.

ACS Infect Dis

August 2024

Department of Infectious Diseases, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen University Medical School, Shenzhen 518052, China.

The primary obstacles in the management of and infections are drug resistance and biofilm formation. Our study revealed that loratadine at a concentration of ≥25 μM exhibited significant inhibitory effects on biofilm formation in 167 clinical strains of and 15 clinical isolates of , , and . Additionally, the antibiofilm activity against and was demonstrated by several loratadine derivatives with altered side-chain carbamate moieties.

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Aims: Since December 2022, an increase in invasive disease caused by Streptococcus pyogenes has been observed in the Czech Republic, with a shift in the clinical presentation and age of patients. Unlike in previous years, invasive disease is more common in children and adolescents under 18 years of age and in previously healthy middle-aged adults. An increase has been noticed in the number of S.

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Introduction: It is currently unclear what the role of Group A streptococcus (GAS) virulence factors (VFs) is in contributing to the invasive potential of GAS. This work investigated the evidence for the association of GAS VFs with invasive disease.

Methods: We employed a broad search strategy for studies reporting the presence of GAS VFs in invasive and non-invasive GAS disease.

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[group A streptococci (GAS)] is the causative agent of pharyngitis and various other syndromes involving cellulitis, streptococcal toxic shock syndrome (STSS), and necrotising fasciitis. Although the prevalence of GAS infections globally remains high, necessitating the widespread use of β-lactam antibiotics, GAS have remained largely susceptible to these agents. However, there have been several reports of GAS with reduced susceptibility harbouring mutations in genes for penicillin-binding proteins (PBPs).

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Article Synopsis
  • Group A β haemolytic streptococcus (GAS) is a pathogen that causes various infections in humans, and this study analyzed 51 GAS isolates from invasive infections in Sri Lanka.
  • The isolates were tested for resistance to antibiotics like erythromycin and tetracycline, revealing that all were susceptible to penicillin and showing diverse patterns of resistance and virulence markers.
  • Key findings included a 70.6% non-susceptibility rate to tetracycline and the detection of significant virulence markers, indicating a varied genetic background among the isolates.
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Group A streptococcus (GAS) can cause serious invasive disease in humans with a high mortality rate. An increase in GAS infections was reported in Ireland in 2022, and this increase has been sustained in 2023 and is paralleled by similar trends in Europe. Rising antimicrobial resistance is a global problem and presents significant challenges to clinicians treating GAS infection.

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Background: There is concern regarding the increasing resistance of Group A streptococcus (GAS) to routinely used antibiotics. GAS is a common cause of bacterial pharyngitis and more severe invasive infections such as septicaemia. Furthermore, GAS pharyngitis is the antecedent for serious conditions such as rheumatic fever and rheumatic heart disease.

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Article Synopsis
  • - A 52-year-old healthy woman was diagnosed with erysipelas, a skin infection, that appeared unusually on her abdomen and breast.
  • - She responded well to medical treatment, indicating potential for recovery.
  • - The case highlights the importance of being alert for atypical presentations of infections for quicker diagnosis and better management.
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Emerging infection: streptococcal toxic shock-like syndrome caused by group B Streptococcus (GBS), .

Autops Case Rep

June 2024

Howard University Hospital, Department of Pathology and Laboratory Medicine, Washington, D.C., United States of America.

or Group B (GBS) infections are commonly associated with infections in neonates and pregnant women. However, there has been a rising incidence in nonpregnant adults. The risk of GBS infection in nonpregnant adults is increased for patients of advanced age and those with underlying medical conditions such as diabetes mellitus and cancer.

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This retrospective study reviewed the macrolide resistance rates of Group A Streptococcus (GAS) isolates in the Northern Territory from 2012 to 2023. Clindamycin and erythromycin resistance rates peaked in 2021, at 6.0% and 12.

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Invasive group A streptococci infections are increasing worldwide, mainly due to the emm1 lineage M1UK emergence. Although this variant has recently been described in adult Italian patients, its circulation in children has not yet been established. Characterizing by whole genome sequencing 6 invasive group A streptococci strains isolated between 2022 and 2023, we highlighted M1UK lineage circulation in pediatric patients in Italy.

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Pangenome evaluation of gene essentiality in .

Microbiol Spectr

August 2024

Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Bacterial species often consist of strains with variable gene content, collectively referred to as the pangenome. Variations in the genetic makeup of strains can alter bacterial physiology and fitness. To define biologically relevant genes of a genome, genome-wide transposon mutant libraries have been used to identify genes essential for survival or virulence in a given strain.

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Molecular methods enhance the detection of pyoderma-related Streptococcus pyogenes and emm-type distribution in children.

J Infect Dis

July 2024

Division of Clinical Medicine and NIHR Sheffield Biomedical Research Centre, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom.

Background: Streptococcus pyogenes-related skin infections are increasingly implicated in the development of rheumatic heart disease (RHD) in lower-resourced settings, where they are often associated with scabies. The true prevalence of S. pyogenes-related pyoderma may be underestimated by bacterial culture.

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Background: This case highlights several complications of a late and rare presentation of culture-negative Streptococcus pyogenes endocarditis of a previously repaired mitral valve with an annuloplasty ring including recurrent cardioembolic strokes, which was initially missed on transthoracic echocardiography.

Case Presentation: A 66-year-old Caucasian female with prior mitral valve prolapse status post mitral valve annuloplasty and left atrial appendage occlusion, followed by two strokes, presented with supraventricular tachycardia that resolved spontaneously. During an inpatient admission, she developed symptoms of another stroke, and imaging studies were suggestive of recurrent cardioembolic phenomenon.

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Many CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated protein) systems, which provide bacteria with adaptive immunity against phages, are transcriptionally repressed in their native hosts. How CRISPR-Cas expression is induced as needed, for example, during a bacteriophage infection, remains poorly understood. In Streptococcus pyogenes, a non-canonical guide RNA tracr-L directs Cas9 to autorepress its own promoter.

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() is a gram-positive, facultative anaerobic bacterium that appears as cocci in chains and commonly causes skin infections and pharyngitis. Here, we present a very uncommon case of cholangitis associated with invasive infection in a 34-year-old man with metastatic pancreatic adenocarcinoma who presented with fever, right upper quadrant pain, jaundice, altered mental status, and hypotension. The patient underwent a percutaneous transhepatic cholangiogram, showing moderate dilatation of intrahepatic biliary ducts with obstruction of the proximal common bile duct, and an internal/external biliary drain was placed to allow for the flow of bile.

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How to Survive Sepsis: Patient Testimonial.

Semin Respir Crit Care Med

August 2024

Ghent, Belgium.

Leaving university I started working for the Belgian National Radio as a journalist. I used to travel a lot and produce radio features about life abroad and how people all over the world dealt with the different challenges in society. A privileged job that I enjoyed doing for many years.

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Divergent effects of types 1 and 12 on invasive group A streptococcal infections-results of a retrospective cohort study, Germany 2023.

J Clin Microbiol

August 2024

Institute of Clinical Microbiology, Infectious Diseases and Infection Control, Paracelsus Medical University, Nuremberg General Hospital, Nuremberg, Germany.

As a potential side effect of the severe acute respiratory syndrome coronavirus type 2 pandemic, invasive group A (iGAS) infections in Europe have increased dramatically in both children and adults in the end of 2022. This epidemiological and molecular study describes the distributions of streptococcal genes encoding the M antigen ( types) and superantigens in patients with invasive and non-invasive GAS infections. From December 2022 to December 2023, a total of 163 GAS isolates were collected from sterile and non-sterile sites of patients at five hospitals in Germany including two tertiary care centers.

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Article Synopsis
  • * Research shows that essential oils possess significant antimicrobial activity against skin-associated pathogens, like Staphylococcus aureus and Candida albicans, using methods like agar disc diffusion and minimum inhibitory concentration tests.
  • * The review emphasizes the need for more research on other less-studied skin pathogens and details the mechanisms by which essential oils combat these microorganisms, offering valuable insights for treating skin infections.
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