14,209 results match your criteria: "Streptococcus Group A Infections"
Cureus
September 2024
Infectious Diseases Department, Unidade Local de Saúde Gaia e Espinho, Vila Nova De Gaia, PRT.
Microbiol Spectr
November 2024
Department of Biopharmaceutical Sciences, Center for Biomolecular Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.
Carbon catabolite repression (CCR) is a widely conserved regulatory process that ensures enzymes and transporters of less-preferred carbohydrates are transcriptionally repressed in the presence of a preferred carbohydrate. This phenomenon can be regulated via a CcpA-dependent or CcpA-independent mechanism. The CcpA-independent mechanism typically requires a transcriptional regulator harboring a phosphotransferase regulatory domain (PRD) that interacts with phosphoransferase ystem (PTS) components.
View Article and Find Full Text PDFObjectives: Genetic characterization of the antibiotic resistance determinants and associated mobile genetic elements (MGEs) among Streptococcus pyogenes [Group A streptococci (GAS)] clinical isolates of an M77 serotype collected in Poland between 2003 and 2017.
Methods: The genomes of 136 M77 GAS isolates were sequenced using Illumina, and selected with long-read approach (Oxford Nanopore). Whole genome sequences were analyzed to determine the presence of macrolide resistance determinants, and their genetic context.
Analyst
November 2024
Department of Laboratory Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.
() is a pathogen typically transmitted through respiratory droplets and skin contact, causing an estimated 700 million mild non-invasive infections worldwide each year. There are approximately 650 000 infections that progress to severe invasive infections, even resulting in death. Therefore, the ability to detect rapidly, accurately and in real time is important.
View Article and Find Full Text PDFJ Infect Dis
October 2024
Department of Infectious Diseases, Fiona Stanley Fremantle Hospitals Group, Murdoch, Western Australia, Australia, 6150.
Background: Rising incidence of invasive beta-haemolytic streptococcal (iBHS) infections has prompted consideration of vaccination as a preventative strategy for at-risk populations. The benefits of a vaccine targeting Lancefield group A (Streptococcus pyogenes; Strep A) would increase if cross-species immunity against Lancefield groups C/G (Streptococcus dysgalactiae subspecies equisimilis; SDSE) and B (Streptococcus agalactiae; GBS) was demonstrated.
Methods: A prospective, observational study of adult patients with iBHS infections due to Strep A, SDSE or GBS.
Cureus
September 2024
Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, HKG.
Group A Streptococcus (GAS) empyema, though rare in adults, poses serious clinical challenges. We present two cases of GAS-induced right empyema in immunocompetent patients. Case 1 involved a 45-year-old female Chinese healthcare worker with persistent pleural effusion despite antibiotic therapy.
View Article and Find Full Text PDFInfect Drug Resist
September 2024
Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Virulence
December 2024
Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Aust J Gen Pract
October 2024
MBChB, FRACGP, PhD, Professor in General Practice, College of Medicine and Dentistry, James Cook University, Mackay, Qld.
BMC Infect Dis
October 2024
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
BMC Infect Dis
October 2024
Faculty of Medicine, Al-Quds University, Abu Dis, Palestine.
Nat Commun
October 2024
Université Paris Cité, Institut Cochin, INSERM, U1016, CNRS, UMR8104, Paris, France.
In Streptococcus pyogenes, the type II fatty acid (FA) synthesis pathway FASII is feedback-controlled by the FabT repressor bound to an acyl-Acyl carrier protein. Although FabT defects confer reduced virulence in animal models, spontaneous fabT mutants arise in vivo. We resolved this paradox by characterizing the conditions and mechanisms requiring FabT activity, and those promoting fabT mutant emergence.
View Article and Find Full Text PDFEuro Surveill
October 2024
Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Epidemiol Infect
October 2024
The Royal Melbourne Hospital, Melbourne, VIC, Australia.
J Antimicrob Chemother
December 2024
Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia.
Objectives: Biofilm is the major challenge in chronic wound management. Instilling a wound cleansing solution aids in wound bed cleaning and infectious pathogen elimination. Negative pressure wound therapy (NPWT) improves the wound-healing process.
View Article and Find Full Text PDFmSphere
October 2024
Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University Zurich, Zurich, Switzerland.
BMC Microbiol
September 2024
Department of Molecular Genetics and Infection Biology, University of Greifswald, Greifswald, Germany.
Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) is increasingly recognized as an emerging cause of invasive diseases including necrotizing soft tissue infections (NSTIs). In contrast to the closely related Streptococcus pyogenes, SDSE infections mainly affect older and comorbid patients. Biofilm formation has been demonstrated in soft tissue biopsies of S.
View Article and Find Full Text PDFPathog Dis
February 2024
School of Science & Technology, University of New England, NSW, Australia.
Post-streptococcal glomerulonephritis (PSGN) is primarily associated with preceding group A streptococcal skin or throat infections, now mainly observed in economically disadvantaged communities. This condition significantly predisposes individuals to later-life chronic kidney disease and concurrent renal complications, with the elderly experiencing increased severity and less favourable outcomes. Streptococcal pyrogenic exotoxin B and nephritis-associated plasmin receptor are identified nephritogenic antigens (nephritogens).
View Article and Find Full Text PDFPlants (Basel)
September 2024
Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
Medicinal plants have traditionally been used to treat various human diseases worldwide. In this study, we evaluated the leaf extracts of plants from the Acanthaceae family, specifically (Burm.f.
View Article and Find Full Text PDFInt J Environ Res Public Health
September 2024
School of Public Health, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
Genes (Basel)
September 2024
Department of Biology, Indiana State University, 600 Chestnut St. S224, Terre Haute, IN 47809, USA.
, commonly known as Group A Streptococcus (GAS), is a significant human pathogen responsible for a wide range of diseases, from mild pharyngitis to severe conditions such as necrotizing fasciitis and toxic shock syndrome. The increasing antibiotic resistance, especially against macrolide antibiotics, poses a challenge to the effective treatment of these infections. This paper reviews the current state and mechanisms of antibiotic resistance in .
View Article and Find Full Text PDFRadiol Case Rep
December 2024
Department of Radiology, Maimonides Medical Center, 4802 10th Avenue, Brooklyn, NY 11219 USA.
J Hand Surg Eur Vol
September 2024
Department of Orthopedic Surgery, University of Alabama, Heersink School of Medicine, Birmingham, AL, USA.
We describe a case of Group A streptococcal infection originally presenting as flexor tenosynovitis. Group A outbreaks have been recently described in developed countries, which constitutes an epidemiological shift that hand surgeons should be aware of.
View Article and Find Full Text PDFJCI Insight
November 2024
Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Despite growing recognition, neuropsychiatric diseases associated with infections are a major unsolved problem worldwide. Group A streptococcal (GAS) infections can cause autoimmune sequelae characterized by movement disorders, such as Sydenham chorea, and neuropsychiatric disorders. The molecular mechanisms underlying these diseases are not fully understood.
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