5 results match your criteria: "Strasbourg University and CNRS[Affiliation]"
Immunotherapies Targeting Amyloid and Tau Protein in Alzheimer's Disease: Should We Move Away from Diseases and Focus on Biological Targets? A Systematic Review and Expert Opinion.
Neurol Ther
December 2023
Center for Clinical Investigation, INSERM U1434, Strasbourg, France.
Article Synopsis
- - Alzheimer’s disease is the leading cause of dementia globally, and recent therapies targeting amyloid and tau proteins show promise, with three drugs (lecanemab, donanemab, and aducanumab) nearing market release.
- - A systematic review of 165 clinical trials revealed 40 published studies on anti-amyloid and anti-tau therapies, with several showing efficacy in reducing amyloid and tau levels in the brain.
- - The discussion emphasizes that while anti-amyloid therapies dominate, effective patient selection for these drugs may depend on genetic factors, such as the presence of the apolipoprotein E gene's fourth allele.
Datasets for calcium dynamics comparison between the whole-cell and a β-escin based perforated patch configuration in brain slices from adult mice.
Data Brief
December 2021
Biocenter, and Cologne Excellence Cluster in Aging Associated Diseases (CECAD), Institute for Zoology, University of Cologne, Cologne, Germany.
Multiple processes shape calcium signals in neurons. The spatial and temporal dynamics of these signals are determined by various cellular parameters, including the calcium influx, calcium buffering, and calcium extrusion. The different Ca handling properties can be estimated using the 'added buffer approach' [1], which is based on a single compartment model of Ca buffering.
View Article and Find Full Text PDFA simple method for getting standard error on the ratiometric calcium estimator.
MethodsX
October 2021
Institute for Zoology, Biocenter and Cologne Excellence Cluster in Aging Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
The ratiometric fluorescent calcium indicator Fura-2 plays a fundamental role in the investigation of cellular calcium dynamics. Despite of its widespread use in the last 30 years, only one publication (Joucla et al., 2010)) proposed a way of obtaining confidence intervals on fitted calcium dynamic model parameters from single 'calcium transients'.
View Article and Find Full Text PDFIs the lack of respiratory gating prejudicial for left breast TomoDirect treatments?
Phys Med
May 2016
Division of Medical Physics, Department of Radiotherapy, Paul Strauss Center, Strasbourg, France.
Background And Purpose: TomoDirect (TD) can only operate in free-breathing. The purpose of this study is to compare TD with breath-hold 3D conformal radiotherapy (3DCRT) and intensity modulated radiotherapy (IMRT) techniques for left breast treatments, and to determine if the lack of respiratory gating is a handicap for cardiac sparing.
Materials And Methods: 15 patients treated for left breast had two computed tomography simulation, in free breathing (FB) and in deep-inspiration breath-hold (DIBH).
Molecule-light complex: dynamics of hybrid molecule-surface plasmon states.
Angew Chem Int Ed Engl
February 2010
ISIS, Strasbourg University and CNRS, 8 allée G. Monge, 67000 Strasbourg, France.