8,006 results match your criteria: "Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis"
Letter to Editor on Dual Anti-Epileptics Induced Stevens-Johnson Syndrome: A Case Report.
JNMA J Nepal Med Assoc
June 2024
Department of Dermatology and Venereology, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.
The role of intravenous immunoglobulin in autoimmune diseases with dermatological implications.
Ital J Dermatol Venerol
October 2024
School of Medicine, Clinic of Dermatology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
Article Synopsis
- Intravenous immunoglobulin (IVIG) therapy shows promise for treating various dermatological autoimmune diseases due to its ability to modulate the immune system and low risk of severe side effects.
- The exact mechanism of how IVIG works in autoimmune diseases is still debated, but it involves neutralizing harmful autoantibodies and preventing tissue damage.
- While IVIG is primarily used off-label for conditions like dermatomyositis and systemic sclerosis, a key study (ProDERM 2022) demonstrated its effectiveness specifically for dermatomyositis, and it is commonly used as first-line treatment for scleromyxedema.
Atypical Stevens-Johnson Syndrome in a Patient With Mycoplasma pneumoniae Infection: A Case Report.
Cureus
October 2024
Internal Medicine, University Hospitals of Derby and Burton NHS Foundation Trust, Burton, GBR.
Article Synopsis
- - Stevens-Johnson syndrome (SJS) is a severe condition that leads to severe skin and mucous membrane damage, marked by skin cell death and peeling.
- - The case report focuses on a young adult who developed atypical SJS as a complication of an infection, highlighting its rarity.
- - The goal is to expand awareness and knowledge about atypical SJS among healthcare professionals, especially in cases that present with mucosal rashes linked to infections.
Toxic Epidermal Necrolysis Observed in a Patient With the HLA-B*1502 Treated With Levofloxacin.
Clin Ther
December 2024
Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:
Article Synopsis
- - The study aimed to explore how mutations in the HLA-B gene relate to toxic epidermal necrolysis (TEN) caused by levofloxacin.
- - A 71-year-old woman experienced TEN after taking levofloxacin and solifenacin, and genetic testing revealed she was positive for the HLA-B*1502 allele and negative for HLA-B*5801.
- - The findings suggest that HLA-B*1502 mutations may play a role in levofloxacin-induced TEN, marking the first report of this connection.
Incidence, In-Hospital and Long-Term Mortality, and Sequelae of Epidermal Necrolysis in Adults.
JAMA Dermatol
December 2024
Service de Dermatologie, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France.
Article Synopsis
- The study investigates the incidence and mortality rates of epidermal necrolysis (EN), including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), analyzing data from adult patients in the French Health System over nine years.
- It found an in-hospital mortality rate of 19% and a postdischarge mortality rate of 15%, leading to an overall mortality of 34% among patients.
- Key factors influencing in-hospital mortality include age, history of cancer, dementia, liver disease, and the severity of EN, with cancer and liver disease also impacting postdischarge mortality.
Steven-Johnson Syndrome/Toxic Epidermal Necrolysis is Associated with PD-1/PD-L1 Inhibitors Usage: A Case Series.
Br J Hosp Med (Lond)
September 2024
Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou, Zhejiang, China.
Article Synopsis
- - The use of PD-1 and PD-L1 inhibitors in cancer treatment in China has led to increased awareness of serious side effects, such as skin conditions like Steven-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
- - A study reviewed cases from 2012 to 2024 at a dermatology hospital, identifying 12 patients with SJS/TEN linked to different PD-1/PD-L1 inhibitors and analyzing factors like onset timing and treatment responses.
- - The findings highlight a possible connection between these cancer treatments and severe skin reactions, providing valuable insights for managing SJS/TEN in affected patients.
Safety assessment of sulfasalazine: a pharmacovigilance study based on FAERS database.
Front Pharmacol
September 2024
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Article Synopsis
- Sulfasalazine is an anti-inflammatory medication commonly used for autoimmune disorders, but its real-world safety hasn't been thoroughly studied, prompting an analysis of adverse reactions from the FDA's database.
- A study analyzed 7,156 adverse event reports related to sulfasalazine and found 101 significant adverse reactions, including some already known and new signals not previously listed in drug labeling, like aseptic meningitis.
- The research reinforces existing knowledge about sulfasalazine's safety while also highlighting new potential adverse effects, contributing to better clinical decision-making and risk management.
S3 guideline: Diagnosis and treatment of epidermal necrolysis (Stevens-Johnson syndrome and toxic epidermal necrolysis) - Part 1: Diagnosis, initial management, and immunomodulating systemic therapy.
J Dtsch Dermatol Ges
October 2024
Department of Dermatology, Venereology and Allergology, Division of Evidence Based Medicine (dEBM), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious, mostly drug-related conditions that affect the skin and mucous membranes, categorized under the umbrella term epidermal necrolysis (EN), which varies in severity.* -
- A new guideline for diagnosing and treating SJS/TEN was created based on extensive scientific research and consensus among experts, involving various medical specialties to provide a comprehensive approach to patient care.* -
- The guideline is designed for healthcare professionals across multiple fields, as well as patients, their families, insurers, and policymakers, with the first part specifically addressing diagnosis, initial treatment, and systemic immunotherapy.*
Long-term outcomes of eyelash-sparing surgical technique for severe segmental cicatricial entropion.
Eur J Ophthalmol
September 2024
Hariram Motumal Nasta & Renu Hariram Nasta Ophthalmic Plastic Surgery Services, LV Prasad Eye Institute, Hyderabad, Telangana, India.
Article Synopsis
- A study evaluated the long-term effectiveness of anterior lamellar recession (ALR) with mucous membrane graft (MMG) for correcting severe segmental cicatricial entropion in 16 patients, primarily affected by Stevens-Johnson Syndrome and chemical injuries.
- The procedure achieved a high anatomical success rate of 87.5% at six weeks, with full correction of entropion in all eyelids by the final follow-up at an average of 14.8 months.
- Patients reported improvements in ocular surface symptoms and visual acuity, and none expressed cosmetic concerns about their appearance after the treatment.
Toxic epidermal necrolysis following heart transplantation may caused by cefoperazone sodium and sulbactam sodium.
J Cardiothorac Surg
September 2024
Department of Cardiac Surgery Intensive Care Unit, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.
Article Synopsis
- * A 56-year-old male with dilated cardiomyopathy faced a serious skin condition (toxic epidermal necrolysis) after receiving certain antibiotics during his heart transplant surgery but was successfully treated with various immunomodulatory therapies and physical rehabilitation.
- * The case emphasizes that striking a balance between immunosuppression and infection prevention is crucial for achieving the best results in heart transplantation, reinforcing the importance of tailored immunosuppressive plans.
Advancements in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Treatment: Utilizing Fas-FasL Inhibition to Target Cell Death Signaling Pathways for Practical Human Application.
J Invest Dermatol
September 2024
Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address:
A case of Stevens-Johnson syndrome after influenza a virus infection.
J Dermatol
September 2024
Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Mie, Japan.
Distinguishing Generalized Bullous Fixed Drug Eruption From SJS/TEN: A Retrospective Study on Clinical and Demographic Features.
Cutis
August 2024
Department of Dermatology, Weill Cornell Medicine, New York, New York.
Pediatric Necrotizing Otitis Externa: A Scoping Review.
Ann Otol Rhinol Laryngol
November 2024
Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, SC, USA.
Article Synopsis
- The review looked into a serious ear infection called necrotizing otitis externa (NOE) in children and what we know about it so far.
- They found 20 studies on this issue, which included 439 kids, and noted that the average age of patients was around 10 years old.
- While diabetes is a big concern in adults with NOE, it’s not as common in kids; instead, children with weakened immune systems or other severe health issues are more affected.
Stevens-Johnson syndrome/toxic epidermal necrolysis: international consensus, advances and opportunities.
Br J Dermatol
September 2024
Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
Development of Esophageal Epidermoid Metaplasia in a Pediatric Patient After Stevens-Johnson Syndrome.
ACG Case Rep J
September 2024
Department of Pediatrics, University of California Davis, Davis, CA.
Article Synopsis
- Esophageal epidermoid metaplasia (EEM) is a rare condition linked to Stevens-Johnson syndrome (SJS), previously documented only once in kids.
- This report discusses the first case of EEM in an 8-year-old girl who developed esophageal stricture after experiencing SJS.
- Pediatric patients with difficulty swallowing post-SJS should be checked for esophageal stricture and potential EEM, with recommended close monitoring and genetic testing due to the cancer risk associated with EEM.
Stevens-Johnson syndrome and toxic epidermal necrolysis-like eruptions in patients treated with immune checkpoint inhibitors: a systematic review.
Int J Dermatol
December 2024
Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
Article Synopsis
- Immune checkpoint inhibitors (ICIs) are revolutionizing cancer treatment but pose risks for severe skin reactions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which need more study.
- This systematic review examined 158 cases to analyze factors related to SJS/TEN in ICI patients to improve risk assessment and clinical management.
- Findings show that SJS/TEN typically occurs in older males, often linked to PD-1 inhibitors, and highlights significant morbidity and mortality risks, though limitations exist in the data reporting and consistency.
Update on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Diagnosis and Management.
Am J Clin Dermatol
November 2024
Department of Dermatology, Emek Medical Center, Afula, Israel.
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious, drug-induced skin conditions with high rates of illness and death, creating challenges for healthcare providers.
- Despite numerous documented cases, there is a lack of agreed-upon diagnostic criteria and treatment options for SJS/TEN.
- Recent advancements in understanding the genetic factors and causes of SJS/TEN are discussed in this review, along with updated strategies for diagnosis and management over the past five years.
[Stevens-Johnson syndrome].
Dermatologie (Heidelb)
October 2024
Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, LMU München, Frauenlobstr. 9-11, 80337, München, Deutschland.
Stevens-Johnson syndrome/toxic epidermal necrolysis: initial assessment.
BMJ
September 2024
Department of Dermatology, Singapore General Hospital, Singapore.
Management of Vulvovaginal Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
Obstet Gynecol
December 2024
Keck School of Medicine of USC, and the Department of Obstetrics and Gynecology and the Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, California.
Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is an autoimmune process resulting in painful epidermal sloughing that can involve the vulva and vagina. Current guideline recommendations are based on expert opinion and may not reflect modern management of SJS/TEN in burn centers. We performed a retrospective chart review of 34 female patients treated for SJS/TEN at our burn center from 2015 to 2023.
View Article and Find Full Text PDFNon-IgE-mediated drug-induced hypersensitivity reactions in pediatrics.
Curr Opin Pediatr
December 2024
Division of Clinical Pharmacology, Departments of Medicine and Pharmacology.
Purpose Of Review: Despite their prevalence and potential severity, non-IgE-mediated drug-induced hypersensitivity reactions (DHRs) are under-researched and poorly defined, particularly in children. Presentations range from mild cutaneous reactions to severe systemic diseases, with pathophysiological mechanisms and reliable diagnostic markers not well established. The lack of validated tests often leads to permanent drug restrictions, reliance on second-line drugs, and increased costs.
View Article and Find Full Text PDFA case report of Stevens-Johnson syndrome caused by omeprazole.
Medicine (Baltimore)
September 2024
Department of Gastroenterology, Shaanxi Provincial People's Hospital, Xi'an, China.
Article Synopsis
- Stevens-Johnson syndrome (SJS) is a serious condition marked by painful skin and mucosal blistering, often leading to significant complications like pneumonia and organ failure.
- A 51-year-old woman developed SJS after taking omeprazole, which resulted in worsening liver function and chronic acute liver failure.
- After stopping the suspected medication and administering supportive treatments, the patient's rash resolved and her liver and kidney functions improved significantly, highlighting the need for understanding drug-induced SJS in patients with liver conditions.
A severe case of reactive infectious mucocutaneous eruption associated with two possible triggers: Coronavirus and group A streptococcus.
Pediatr Dermatol
September 2024
Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Reactive infectious mucocutaneous eruption (RIME) is a newly defined condition characterized by mucocutaneous blistering secondary to upper respiratory infections and encompasses Mycoplasma pneumoniae-induced rash and mucositis, broadening the disease spectrum to include various infectious etiologies. We present a severe RIME case involving a 5-year-old female with concurrent coronavirus NL63 and group A streptococcus infections. Diagnosis complexity stemmed from overlapping clinical features with other severe mucocutaneous eruptions such as Stevens-Johnson syndrome/toxic epidermal necrolysis/drug-induced necrolysis.
View Article and Find Full Text PDFStevens-Johnson syndrome and toxic epidermal necrolysis: Updates in pathophysiology and management.
Chin Med J (Engl)
October 2024
Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.
Article Synopsis
- - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin conditions with high mortality rates characterized by skin and mucous membrane detachment, but their causes and best treatments are still unclear.
- - Early diagnosis is difficult, and while some drugs are linked to SJS/TEN, HLA screening may help reduce risk, with new biomarkers identified for diagnosis and prognosis.
- - Treatment typically involves supportive care, but the effectiveness of various therapies like corticosteroids and immunoglobulin is debated, with recent studies examining the role of TNF-α antagonists in management.