409 results match your criteria: "Stem Cell Technology Research Center[Affiliation]"

Glioblastomas are highly invasive brain tumors among perilous diseases. They are characterized by their fast proliferation and delayed detection that render them a significant focal point for medical research endeavors within the realm of cancer. Among glioblastomas, (GBM) is the most aggressive and prevalent malignant brain tumor.

View Article and Find Full Text PDF

Background: Burn injury is still the leading cause of mortality and morbidity in burn patients. We comapred healing effect of , silver sulfadiazine and alpha ointments on burn injuries in rat model.

Methods: Sixty female Sprague-Dawley rats in an animal experimental study were randomly divided to 5 equal groups as , silver sulfadiazine and (SSD), alpha, gel base and the burn injury left untreated.

View Article and Find Full Text PDF

Multipotent mesenchymal stromal/stem cells (MSCs) refer to a population of stem cells that exhibit distinct progenitor cell characteristics including the potential for differentiation into a wide range of cell types. MSCs have become a promising candidate for cell therapy and tissue regeneration due to their unique properties, such as their ability to differentiate into multiple cell types, their capacity for expansion, self-renewal, and immune-regulatory effects. However, reports have brought attention to thrombosis-related complications associated with MSCs therapy in the last decade.

View Article and Find Full Text PDF
Article Synopsis
  • Heart rate variability (HRV) has potential as a tool for assessing the severity of hemorrhagic shock (HS) by comparing it with traditional methods of measuring hemodynamic and metabolic parameters.
  • The study involved male Sprague-Dawley rats subjected to varying degrees of HS, revealing that HRV changes, particularly in low-frequency power and respiratory sinus arrhythmia, correlate with blood pressure and tissue perfusion.
  • Despite observed HRV alterations being linked to hemodynamic factors, they didn’t show a direct connection with inflammatory responses in the animals.
View Article and Find Full Text PDF

Background: Uncontrolled bleeding is still the major factor leading to preventable deaths following trauma. This study sought to assess the effectiveness of mini sponge-based wound stasis, cellulose-based local hemostatic, and traditional gauze dressings for the control of hemorrhages resulting from grade 4 liver injuries in rats.

Methods: Thirty Sprague-Dawley rats were divided into three equal groups.

View Article and Find Full Text PDF

A pan-cancer analysis summarizing the overall changes in mRNA and protein stability of ADM9, as well as its oncogenic function on immune cell line modulation and checkpoints within the tumor microenvironment (TME), is lacking, despite the fact that ADM9 up-regulation is correlated with the progression of many cancers. Therefore, in this study, we comprehensively analyzed the role of ADAM9 expression and its prognostic value in different cancers to fill this gap. Multiple bioinformatics databases such as Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Clinical Proteomic Tumor Analysis Consortium (CPTAC) were used to evaluate the ADAM9 genetic alternation, phosphorylation, and methylation, and indicated highly positive correlated genes that might play a critical interaction with ADAM9 and their molecular function with GO analysis.

View Article and Find Full Text PDF

The larynx is responsible for breathing, producing sound, and protecting the trachea against food aspiration through the cough reflex. Nowadays, scaffolding surgery has made it easier to regenerate damaged tissues by facilitating the influx of cells and growth factors. This review provides a comprehensive overview of the current knowledge on tissue engineering of the larynx and vocal folds.

View Article and Find Full Text PDF

Osteochondral tissue engineering using layered scaffolds is a promising approach for treating osteochondral defects as an alternative to microfracture procedure, autologous chondrocyte implantation, and cartilage-bone grafting. The team previously investigated the chondrogenesis of mesenchymal stem cells (MSCs) on a polycaprolactone (PCL)/acetylated hyaluronic acid scaffold. The present study first focused on fabricating a novel osteoconductive scaffold utilizing bismuth-nanohydroxyapatite/reduced graphene oxide (Bi-nHAp/rGO) nanocomposite and electrospun PCL.

View Article and Find Full Text PDF

The limited self-repair capacity of articular cartilage is a challenge for healing injuries. While mesenchymal stem/stromal cells (MSCs) are a promising approach for tissue regeneration, the criteria for selecting a suitable cell source remain undefined. To propose a molecular criterion, dental pulp stem cells (DPSCs) with a -negative expression pattern and bone marrow mesenchymal stromal cells (BMSCs), which actively express genes, were differentiated towards chondrocytes in 3D pellets, employing a two-step protocol.

View Article and Find Full Text PDF

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. The cleavage factor Im 25 (CFIm25), a crucial component of the CFIm complex, plays a key role in regulating the length of the mRNA 3'-UTR and has been implicated in various cancers, including GBM. This study sought to investigate the regulatory influence of specific microRNAs (miRNAs) on CFIm25 expression in GBM, a highly aggressive brain tumor.

View Article and Find Full Text PDF

Objective: Neurological and functional impairments are commonly observed in individuals with spinal cord injury (SCI) due to insufficient regeneration of damaged axons. Exosomes play a crucial role in the paracrine effects of mesenchymal stem cells (MSCs) and have emerged as a promising therapeutic approach for SCI. Thus, this study aimed to evaluate the safety and potential effects of intrathecal administration of allogeneic exosomes derived from human umbilical cord MSCs (HUC-MSCs) in patients with complete subacute SCI.

View Article and Find Full Text PDF

Vascular tissue engineering is a promising approach for regenerating damaged blood vessels and developing new therapeutic approaches for heart disease treatment. To date, different sources of cells have been recognized that offer assistance within the recovery of heart supply routes and veins with distinctive capacities and are compelling for heart regeneration. However, some challenges still remain that need to be overcome to establish the full potential application of these cells.

View Article and Find Full Text PDF

In this study, we delved into the intricate world of autism spectrum disorder (ASD) and its connection to the disturbance in the Wnt signaling pathway and immunological abnormalities. Our aim was to evaluate the impact of silibinin, a remarkable modulator of both the Wnt signaling pathway and the immune system, on the neurobehavioral and molecular patterns observed in a zebrafish model of ASD induced by valproic acid (VPA). Because silibinin is a hydrophobic molecule and highly insoluble in water, it was used in the form of silibinin nanoparticles (nanosilibinin, NS).

View Article and Find Full Text PDF

Background: Sodium butyrate (NaBu) is a short-chain fatty acid; it is one of the histone deacetylase inhibitors, which can alter both genetic and epigenetic expressions. The present study aimed to elucidate the effect of Na-Bu on the expression of miR-21, miR-143, and miR-145 in human colorectal cancer HCT-116 cell lines.

Methods: This study was done in Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

View Article and Find Full Text PDF

Non-small cell lung cancer (NSCLC) has constituted over 80% of the lung cancer population with a poor prognosis. Over the past decade, immunotherapy has been constructed in the enlargement of immune checkpoint inhibitors as a promising approach for NSCLC treatment. Evading the immune system using the PD-1/PD-L1 axis is an intelligent way for cancers, and T cells cannot respond fully and confront cancer.

View Article and Find Full Text PDF

Objectives: Dental pulp stem cells (DPSCs) were shown to play an important role in regenerative medicine including reconstruction of various bone lesions. This study determined the impact of acemannan, an extracted product from , on proliferation of DPSCs and healing of mandibular defects in rabbits.

Methods: DPSCs were isolated and characterized.

View Article and Find Full Text PDF

Objective: Numerous studies have reported the beneficial effects of exercise and the use of herbal supplements in improving type 2 diabetes and insulin resistance. However, there are still many unanswered questions about the effects of cold and hot water, exercise, and herbal supplements on meteorine-like protein (METRNL), which is considered one of the key factors influencing insulin resistance improvement in this condition. Hence, the current study aimed to address these knowledge gaps and investigate the effects of 8 weeks of warm and cold-water swimming exercise with cinnamon consumption on serum levels of METRNL, histone deacetylase-5 (HDAC5), and insulin resistance in diabetic male rats.

View Article and Find Full Text PDF
Article Synopsis
  • * Key factors influencing scaffold effectiveness are discussed, such as porosity, surface chemistry, and degradation behavior, along with common production methods for creating porous materials.
  • * The review also highlights emerging therapies like gene delivery and secretome-based treatments, while outlining both the promising results and significant limitations in the clinical use of new BTE materials.
View Article and Find Full Text PDF

Infertility is a common clinical condition and about half of the major causes are due to male-related infertility. Pathogenesis of this abnormality is generally undefined; so establishing a proper treatment option is relatively uncertain. In recent years, several evidences demonstrated that mesenchymal stem cells (MSCs) can be a hope for innovative and efficient treatment of male infertility.

View Article and Find Full Text PDF
Article Synopsis
  • Tissue engineering in otology focuses on creating and repairing ear tissues, from the outer ear (pinna) to the auditory nerve, addressing both functional hearing and aesthetic concerns.
  • It offers solutions to common issues like tissue shortages, compatibility problems, and transplant rejection by producing tissues that are more like the patient’s own, minimizing the need for immunosuppression.
  • The review discusses recent advancements and ongoing challenges in applying tissue engineering techniques to external, middle, and inner ear structures, highlighting the importance of training for specialists in using different scaffolds for patient recovery.
View Article and Find Full Text PDF

Neuroblastoma is a common inflammatory-related cancer during infancy. Standard treatment modalities including surgical interventions, high-dose chemotherapy, radiotherapy, and immunotherapy are not able to increase survival rate and reduce tumor relapse in high-risk patients. Mesenchymal stem cells (MSCs) are known for their tumor-targeting and immunomodulating properties.

View Article and Find Full Text PDF

Breast cancer has a high prevalence among women, with a high mortality rate. The number of people who suffer from breast cancer disease is increasing, whereas metastatic cancers are mostly incurable, and existing therapies have unfavorable side effects. For an extended duration, scientists have dedicated their efforts to exploring the potential of mesenchymal stem cells (MSCs) for the treatment of metastatic cancers, including breast cancer.

View Article and Find Full Text PDF

Aims: Diabetes is one of the main causes of mortality in developing countries. Performing physical activity in various ways and different environments using herbal supplements can be used as a non-pharmacological solution to prevent and improve diabetes. Hence, this study aimed to investigate the effects of eight weeks of cold water swimming exercise training combined with cinnamon supplementation on HbA1C (Hemoglobin A1c) levels, TBC1D1 (TBC1 domain family member 1), and TBC1D4 (TBC1 Domain Family Member 4) in diabetic rats.

View Article and Find Full Text PDF

Objective: Androgenetic alopecia (AGA) is a prevalent form of hair loss, mainly caused by follicular sensitivity to androgens. Despite developing different anti-androgen treatment options, the success rate of these treatments has been limited. Using animal models, this study evaluated the therapeutic effects of umbilical cord (UC) stem cell conditioned media (CM) combined with oral anti-androgens for hair regeneration.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: