1 results match your criteria: "Steele Memorial Children's Research Center 1501 N. Campbell Avenue[Affiliation]"
Sox6 regulation of cardiac myocyte development.
Nucleic Acids Res
October 2003
Department of Pediatrics, The University of Arizona College of Medicine, Steele Memorial Children's Research Center 1501 N. Campbell Avenue, Tucson, AZ 85724, USA.
Article Synopsis
- A mutation in mice (p100H/p100H) linked to cardioskeletal myopathy and early death disrupts the Sox6 gene, which is important for heart muscle development.
- In an experimental setup, Sox6 was found to be crucial for differentiating cells into beating cardiac myocytes, and interacts with the protein Prtb.
- BMP signaling is necessary for Sox6 expression during this cell differentiation, and both Sox6 and Prtb affect the expression of a key calcium channel involved in heart function.