The information communication technologies in medicine.

The article discusses some aspects of information and communication technologies in medicine. In view of the COVID-19 pandemic, special attention is paid to development of telemedicine. The informational computer technologies are especially relevant where there is shortage of medical personnel.

The effect of green stands on human health.

The article describes the role of green stands in preserving and improving population health. They positively effect human emotional background, improving cognitive functions and mood, forming subjective feeling of cheerfulness, restoring vitality and contribute to normalization of somatic health. The article presents criteria for assessing quality of green stands.

[Microcirculation in fractures of long bones of the lower extremity].

The study objective was to investigate soft tissue microcirculation in the area of a lower limb long bone fracture. We studied fractures of the lower limb long bones from 0 to 7 days of age in 17 males and 37 females. The mean age of patients was 57.

[Rehabilitation of patients with chronic low back pain].

Low back pain occupies one of the leading places among pain syndromes and is an urgent medical, social, and economic problem of our time. A review of modern domestic and foreign literature data on the features of diagnosis, treatment and rehabilitation of chronic dorsalgia in patients with comorbid pathology was carried out. The article reflects the main etiological factors, describes the types of back pain: non-specific (musculoskeletal), radiculopathy, pain associated with potentially dangerous diseases, in addition, issues of the pathogenesis of pain syndromes are highlighted with an indication of nociceptive, neuropathic, psychogenic components.

Hematosalivarian barrier: structure, functions, study methods (review of literature).

The human body consists of various systems (blood, tissues, extracellular fluid, intracellular contents) separated by biological membranes. Physiological barriers ensure the physico-chemical composition of the internal environment remains constant and protects the body from environmental changes. The permeability of the histohematic barrier depends on the concentration of substances in the blood, the body's condition, external influences, and a number of other reasons caused by stimuli coming from the external or internal environment.

[The physicians and the patients: who are they one to another?].

The article considers issues of communication between physicians and patients and presents several models of corresponding relationships. The importance of involving patients in therapeutic partnership is emphasized. The barriers to effective communication between physician and patient and ways to overcome them are considered.

[The urban transport as social economic health determinant].

The article considers role of transport as one of social economic health determinants. The aspects having positive and negative impact on health of population are presented. The necessity to design and plan transport systems considering population needs is postulated.

Cariprazine's Potential in Improving Social Dysfunction in Patients With Schizophrenia: A Perspective.

Social dysfunction is one of the most debilitating aspects of schizophrenia. Treatment of this complex phenomenon, constituted by negative, cognitive, and affective symptoms, has been difficult with the available pharmacological agents, hence it represents an unmet medical need. Cariprazine, a novel, third-generation antipsychotic with a unique mechanism of action has been proven to sufficiently alleviate negative, cognitive, and affective symptoms of schizophrenia.

[The municipal planning for the benefit of health].

The article, on the basis of analysis of scientific publications, presents brief overview of principles and technologies of development of cities considering impact on population health. The particular attention is paid to analysis of being built areas and careful use of available resources. The definition of the term "sustainable development of territory" and description of necessary measures for its application in practice are given.

[Morphofunctional characteristics of the heart in sudden death of children under 1 year of age in the forensic medical aspect].

The aim of this study is to describe the morphological and functional characteristics of the cardiac in sudden infants death syndrome (SIDS) in children under one year of age. Twenty eight cases of SIDS were studied histologically and immunohistochemically. Histological examination of the sectional material was carried out using standard and additional stains.

Novel Antimicrobial Peptides Designed Using a Recurrent Neural Network Reduce Mortality in Experimental Sepsis.

The search and development of new antibiotics is relevant due to widespread antibiotic resistance. One of the promising strategies is the de novo design of novel antimicrobial peptides. The amino acid sequences of 198 novel peptides were obtained using a generative long short-term memory recurrent neural network (LSTM RNN).

[Study of the efficacy and safety of sequential use of the drugs Mexidol and Mexidol FORTE 250 in the treatment of stroke].

Objective: To evaluate the effect of Mexidol on the recovery of cognitive functions in patients after ischemic stroke (IS).

Material And Methods: We examined 70 patients with acute IS, who were randomized into 2 groups by random sampling; The 1st group consisted of patients who, against the background of the main standard therapy for 14 days, received Mexidol intravenously, 500 mg 1 time per day, followed by oral administration of Mexidol FORTE 250, 750 mg per day for 60 days (40 patients; 28 men, 12 women). Group 2 consisted of 30 patients (21 men, 9 women) who received only standard therapy.

[The comparative analysis of level of literacy in issues of health among residents of the Northern Caucasian Federal Okrug].

The article presents the results of comparative analysis of level of health literacy of population of the North Caucasian Federal Okrug of The Russian Federation. The analysis established that the level of functional health literacy of respondents depends on gender, education, standards of living and residence. The lower level of this type of health literacy is established in males, residents of rural areas, individuals with lower standard of living and lower level of education (p<0.

[Surgical treatment of chronic pancreatitis: indications, timing, methods].

The review is devoted to complex treatment of chronic pancreatitis considering modern data on pathogenesis of this disease. The authors analyze various aspects of endoscopic and surgical interventions in refractory pain syndrome and complications of chronic pancreatitis, as well as positive and negative aspects of each method. Various surgical interventions and indications are analyzed in detail.

[Emergency combined surgery for acute appendicitis and cystic lesions of small pelvis].

Objective: To determine the optimal surgical approach for acute appendicitis and concomitant cystic lesions of small pelvis.

Material And Methods: The authors report the results of emergency combined surgery on abdominal and pelvic organs in 995 patients for the period from 1990 to 2020 (30 years). Acute appendicitis was diagnosed in 698 (70.

Antimicrobial Peptides Epinecidin-1 and Beta-Defesin-3 Are Effective against a Broad Spectrum of Antibiotic-Resistant Bacterial Isolates and Increase Survival Rate in Experimental Sepsis.

The antimicrobial peptides human Beta-defensin-3 (hBD-3) and Epinecidin-1 (Epi-1; by ) could be a promising tool to develop novel antibacterials to combat antibiotic resistance. The antibacterial activity of Epi-1 + vancomycin against methicillin-resistant (22 isolates) and Epi-1 + hBD-3 against carbapenem-resistant isolates of ( = 23)  ( = 17) ( = 9), and ( = 13) was studied in vitro. To evaluate the in vivo efficacy of hBD-3 and Epi-1, ICR (CD-1) mice were injected intraperitoneally with a lethal dose of or .

Potential and Possible Therapeutic Effects of Melatonin on SARS-CoV-2 Infection.

The absence of effective drugs for COVID-19 prevention and treatment requires the search for new candidates among approved medicines. Fundamental studies and clinical observations allow us to approach an understanding of the mechanisms of damage and protection from exposure to SARS-CoV-2, to identify possible points of application for pharmacological interventions. In this review we presented studies on the anti-inflammatory, antioxidant, and immunotropic properties of melatonin.

Scaffolds Based on Poly(3-Hydroxybutyrate) and Its Copolymers for Bone Tissue Engineering (Review).

Biodegradable and biocompatible polymers are actively used in tissue engineering to manufacture scaffolds. Biomedical properties of polymer scaffolds depend on the physical and chemical characteristics and biodegradation kinetics of the polymer material, 3D microstructure and topography of the scaffold surface, as well as availability of minerals, medicinal agents, and growth factors loaded into the scaffold. However, in addition to the above, the intrinsic biological activity of the polymer and its biodegradation products can also become evident.

Clinical and Pathogenetic Significance of Amylase Level and Microtomographic Index of Synovial Fluid in Various Joint Lesions.

Unlabelled: was to study the level of amylolytic activity and microtomographic index of synovial fluid density as well as to substantiate their clinical and pathogenetic significance by identifying correlations with the known informative indicators reflecting characteristic features of the pathological process in various joint diseases.

Materials And Methods: Samples of synovial fluid from 95 patients with various joint pathologies at the stage of the disease progression characterized by copious effusion into articular cavities have been examined. Synovial fluid samples obtained by knee arthrocentesis served as a material for the investigation.

High Dose Inhalation with Gaseous Nitric Oxide in COVID-19 Treatment.

A method of treatment of a new coronavirus infection COVID-19 in patients undergoing high flow oxygenation is proposed and technically implemented; the method is based on high-dose inhalation of gaseous nitric oxide (NO) with the patient's spontaneous breathing. The results of the treatment of this disease demonstrating the high efficiency of the new method are presented. A possible mechanism of the blocking effect of high doses of inhaled nitric oxide on the replication of the SARS-CoV-2 virus is discussed; it is based on the formation of dinitrosyl iron complexes in the respiratory tract and lungs of COVID-19 patients with thiol-containing ligands acting as donors of NO and nitrosonium NO cations in a living organism that have a cytotoxic effect on the SARS CoV-2 virus.

[ANALYSIS OF THE SIZE OF THE CEPHALOMETRIC VALUES OF THE FACE AND THE ODONTOMETRIC PARAMETERS OF THE JAWS DURING THE PERIOD OF OCCLUSION CHANGE OF THE DENTAL ROWS].

115 respondents aged 7-11 with occlusive pathology were examined anthropometrically and biometrically. The sizes of the craniofacial complex were studied using the parameters of the width and diagonal of the face. The jaw indices of the face were calculated.

[The development of measures supporting the Northern Caucasian Federal Okrug with qualified medical personnel using trchnologies and resources of the Scientific Educational Medical Cluster "Northern-Caucasian"].

The article presents the results of analysis of educational activities of a medical University. Among the issues that need to be resolved, quality of professional selection of applicants to medical universities, backwardness in time management skills, stress coping and leadership qualities in students are noted. The mechanisms for solving these issues are proposed on the basis of "puzzle technology" - embedding in existing matrix those activities that are capable to qualitatively change the situation in a particular field of higher education.

[Features of pathological anatomy of COVID-19 according to autopsy results in the Volgograd Region].

Unlabelled: In connection with the ongoing pandemic of the novel coronavirus infection, the study of its morphopathology and the analysis of autopsy data are relevant. At the same time, attention should be paid to thromboses that play a significant role in the development of fatal outcomes in COVID-19, even taking into account the prescription of anticoagulant therapy to most patients.

Objective: To make an assessment of morphological changes and a statistical analysis of the structure of mortality in COVID-19 on the basis of autopsy results in the Volgograd Region in 2020.