A Comparative Randomized Clinical Study Assessing the Efficacy of a 1% Selenium Disulfide-Based Shampoo versus 2% Ketoconazole Shampoo in Subjects with Moderate to Severe Scalp Seborrheic Dermatitis.

Introduction: Scalp seborrheic dermatitis (SSD) is a chronic, relapsing, and inflammatory condition impacting quality of life (QoL). This study evaluated the efficacy and impact on QoL of a 1% selenium disulphide-containing shampoo (SeS shampoo) compared to a 2% ketoconazole shampoo.

Methods: This multi-centric, double-blinded, randomized 4-week study was conducted in 64 adult subjects with moderate to severe SSD (SSD severity score (SSSD) > 6).

Changes in the Glittre-ADL test in patients with non-small cell lung cancer: Pre- and postoperative analysis after home-based rehabilitation: A preliminary study.

Background And Objective: Postoperative pulmonary rehabilitation in non-small cell lung cancer (NSCLC) patients following thoracic surgery can be an important strategy for restoring functional exercise capacity. This study aimed to evaluate the changes in the Glittre-ADL test (TGlittre) in patients with NSCLC undergoing thoracic surgery and early home-based pulmonary rehabilitation and, subsequently, to assess the associations of the test results with muscle strength and quality of life (QoL).

Methods: This observational study evaluated 18 patients with NSCLC before and after home-based pulmonary rehabilitation.

Model for predicting drug resistance based on the clinical profile of tuberculosis patients using machine learning techniques.

Tuberculosis (TB) is a disease caused by the bacterium and despite effective treatments, still affects millions of people worldwide. The advent of new treatments has not eliminated the significant challenge of TB drug resistance. Repeated and inadequate exposure to drugs has led to the development of strains of the bacteria that are resistant to conventional treatments, making the eradication of the disease even more complex.

Associations among chronotype and eating habits in adolescents are affected by study shift: A cross-sectional study.

We investigated the influence of chronotype on eating habits among adolescents attending schools with morning (07:00 hours-12:00 hours) or afternoon (13:00 hours-18:00 hours) shifts, hypothesizing that incompatibility of study schedules may be related to dietary choices. In this cross-sectional study, 734 adolescents (aged 14-19 years) completed an online questionnaire covering eating habits, chronotype, sleep duration, social jet lag, socioeconomic data, physical activity and anthropometric measures. Odds ratios with 95% confidence intervals were estimated using adjusted logistic regression, stratified by study shift.

Effectiveness of care provided by an itinerant community caregiver in reducing the burden and violence of family caregivers of impaired elderly in Rio de Janeiro, Brazil: A randomized clinical trial.

Introduction: The aging population and the rise in chronic diseases are linked to a higher number of elderly individuals with impairments. These individuals often depend on family caregivers for basic daily activities, which can impose a significant burden and increase the risk of violence against them.

Objective: To assess the effectiveness of itinerant community caregivers (ICC) in reducing burden, depression and risk of violence among family caregivers of impaired elderly (FCIE), while also increasing their social support.

Micro-computed tomographic evaluation of dentinal microcracks in response to progressive taper enlargement in root canals of maxillary molars.

Aim: To investigate the development of dentinal microcracks resulting from the progressive enlargement of the buccal canals of maxillary molars with and without the MB2 canal employing instruments with the same tip and four different tapers.

Methodology: Twenty maxillary molars with (n = 10) and without (n = 10) the MB2 canal underwent micro-CT scanning. Their mesiobuccal and distobuccal canals were sequentially enlarged using nickel-titanium instruments with sizes 25/.

Analgesic effect of lateral femoral cutaneous nerve block to the pericapsular nerve group (PENG) block in primary total hip arthroplasty: a randomized clinical trial.

Background: Adequate hip joint and surgical incision analgesia represent a challenge in the postoperative period of primary total hip arthroplasty (THA). This study aimed to evaluate whether the combination of the lateral femoral cutaneous nerve block (LFCN block) and the pericapsular nerve group block (PENG block) influences postoperative analgesia and rescue opioids, in primary THA surgeries.

Methods: A trial was proposed with 74 patients for THA surgeries under spinal anesthesia, where 37 received PENG block (GPENG) and the other 37, PENG block and LFCN block (GPENG+LFC).

Maternal schooling and child's age interaction and its association with ultra-processed food consumption in Brazilian children <5 years of age: Results from the Brazilian National Survey on Child Nutrition (ENANI-2019).

Background: The consumption of ultra-processed foods (UPFs) has increased worldwide, including among children. Maternal schooling has been associated with children's UPF consumption. The present study examined the interaction between maternal schooling and child age in the association with UPF consumption in Brazilian children <5 years.

The dichotomic role of cytokines in aging.

The chronic inflammation present in aged individuals is generally depicted as a detrimental player for longevity. Here, it is discussed several beneficial effects associated with the cytokines that are chronically elevated in inflammaging. These cytokines, such as IL-1β, type I interferons, IL-6 and TNF positively regulate macroautophagy, mitochondrial function, anti-tumor immune responses and skeletal muscle biogenesis, possibly contributing to longevity.

Genotoxicity analysis of a flame retardant, aluminum diethylphosphinate.

Flame retardants, crucial for fire prevention, are used worldwide, but they are considered to be 'emerging contaminants' and may pose risks to human and environmental health. Aluminum diethyl phosphinate (ALPI) is a halogen-free flame retardant. To evaluate the toxicity of this compound, the following assays were performed: Salmonella/microsome mutagenicity assay; toxicity assays with two endpoints (mitochondrial dehydrogenase activity, plasma membrane integrity); micronucleus assay with human hepatoma cell line HepG2.

Radiometric evaluation of Ouratea miersii (Planch.) Engl. From the Municipal Natural Park of Niterói, Brazilian Atlantic Rainforest remnant.

Concern about radiation exposure to non-human biota and the environment has increased since the 1990s, resulting in several publications by UNSCEAR, IAEA, ICRP, among other agencies, which highlighted significant gaps in knowledge regarding non-human biota and resulted in the establishment of Reference Animals and Plants (RAPs). In Brazil, the Atlantic Forest biome has vast biodiversity, but there is a lack of information on the radiometric profile of plant species growing there. Thus, the objective of this study was to evaluate the radiometric profile of Ouratea miersii (Malpighiales), endemic to the Atlantic Rainforest, collected in the State of Rio de Janeiro, city of Niterói, at the Municipal Natural Park (PARNIT), which covers a region of protected Atlantic Rainforest.

Outcomes of Oberlin Transfer in Elderly Patients: A Case Series.

Objective: A case series analysis was performed of upper brachial plexus injuries (BPIs) from low-impact trauma in patients ≥60 years old to assess the effectiveness of nerve transfers, particularly the Oberlin technique, in restoring elbow flexion and to refine clinical decision making for managing traumatic BPIs in this age group.

Methods: Between 2013 and 2024, 11 patients aged 60-72 with traumatic upper BPIs underwent Oberlin technique for elbow flexion; all were evaluated with consistent postsurgical criteria.

Results: Trauma mechanisms included falls (55%), direct trauma (27%), knife wounds (9%), and stretching (9%), with no high-impact trauma cases.

Longitudinal H NMR-Based Metabolomics in Saliva Unveils Signatures of Transition from Acute to Post-Acute Phase of SARS-CoV-2 Infection.

COVID-19 can range from a mild to severe acute respiratory syndrome and also could result in multisystemic damage. Additionally, many people develop post-acute symptoms associated with immune and metabolic disturbances in response to viral infection, requiring longitudinal and multisystem studies to understand the complexity of COVID-19 pathophysiology. Here, we conducted a H Nuclear Magnetic Resonance metabolomics in saliva of symptomatic subjects presenting mild and moderate respiratory symptoms to investigate prospective changes in the metabolism induced after acute-phase SARS-CoV-2 infection.

Early Changes in Eating Behavior Patterns and Their Relationship with Weight Outcomes in Patients Undergoing Bariatric Surgery.

Background/objective: Eating behaviors (EB) correlate with weight loss after bariatric surgery (BS). Therefore, the investigation of EB could guide interventions to prevent insufficient weight outcomes.

Method: A prospective cohort of 85 patients undergoing Roux-en-Y Gastric Bypass (RYGB; 84.

Time of Energy Intake: Association with Weight Status, Diet Quality, and Sociodemographic Characteristics in Brazil.

This study aimed to estimate the association of time of energy intake with weight status, diet quality, and sociodemographic characteristics in Brazil. This cross-sectional study used data from a nationally representative survey with 44.744 individuals (≥10 years old).

Effects of intradialytic bicycle ergometer exercise on transcription factors NF-ĸB and Nrf2 in patients with chronic kidney disease: A randomized crossover clinical trial.

Purpose: To evaluate the effects of an intradialytic aerobic exercise training program on the expression of transcription factors nuclear factor κappa B (NF-κB) and nuclear factor erythroid 2-related factor 2 (Nrf2), related to inflammatory and antioxidant pathways, respectively, in patients with chronic kidney disease (CKD) on hemodialysis.

Methods: This was a longitudinal, randomized clinical trial with a washout period and crossover performed with 33 patients randomized into two groups: Exercise (individualized intradialytic aerobic exercise on an adapted stationary exercise bike) three times per week for three months and control (without exercise). After the washout period (1 month), the exercise group became the control, and the other group performed the exercises for another three months.

The impact of social isolation on depression-like behavior in carioca high- and low-conditioned freezing rats.

This study investigated the impact of social isolation in Carioca High-Conditioned Freezing (CHF) rats, an animal model of generalized anxiety disorder (GAD). Animals selected for high (CHF), low trait anxiety (Carioca Low-Conditioned Freezing, CLF), and control rats from randomly bred populations (CTL) were housed in groups or kept isolated in their cages for 14 consecutive days. On the fifteenth day, all animals underwent the Forced Swimming Test (FST), where the latency to immobility was assessed as a depressive-like measure.