ECHINOCOCCUS MULTILOCULARIS IN NEW YORK WILDLIFE: DISTRIBUTION AND GENETIC DIVERSITY OF AN EMERGING PATHOGEN.

Echinococcus is a genus of cestode parasites of paramount veterinary and medical importance globally. Two species, Echinococcus granulosus sensu lato and Echinococcus multilocularis, are endemic to North America and are the etiologic agents of cystic echinococcosis and alveolar echinococcosis, respectively. North America is currently experiencing an epidemiological shift in the state of transmission, distribution, and prevalence of E.

From Isolation to Social (and Psychedelic) Integration: A Sociology of Collective Effervescence and Therapeutic Community in Psychedelic-Assisted Therapy.

There is a disparity between contemporary scientific investigations into psychedelic phenomena and their 20-century counterparts, notably the lack of examination of psychedelic experiences within group settings. Whereas early research studies from the 1950s to the 1970s explored communal settings in psychedelic-assisted therapy (PAT), today's resurgence of scholarship in the field primarily considers individualised, often clinical, settings. Consequently, there is an absence of empirical research and theoretical innovation on collective psychedelic contexts, for example, how social connectedness occurs relationally and what its impacts are.

Atomistic Simulations and Analysis of Peripheral Membrane Proteins with Model Lipid Bilayers.

All-atom molecular dynamics (AAMD) is a computational technique that predicts the movement of particles based on the intermolecular forces acting on the system. It enables the study of biological systems at atomic detail, complements observations from experiments, and can help the selection of experimental targets. Here, we describe the applications of MD simulations to study the interaction between peripheral membrane proteins and lipid bilayers.

A multimodal axial array resonator and its application in radiofrequency (RF) volume coil designs for low-field open magnetic resonance imaging (MRI).

Background: Low-field open magnetic resonance imaging (MRI) systems, typically operating at magnetic field strengths below 1 Tesla, has greatly expanded the accessibility of MRI technology to meet a wide range of patient needs. However, the inherent challenges of low-field MRI, such as limited signal-to-noise ratios and limited availability of dedicated radiofrequency (RF) coils, have prompted the need for innovative coil designs that can improve imaging quality and diagnostic capabilities. In this work, we introduce a multimodal axial array resonator and its implementation in a volume coil, or referred to as a coupled stack-up volume coil, to address these challenges in low-field open MRI.

Rewiring the disordered connectome with circuit-based paired stimulation after stroke-a randomized, double-blind and controlled Phase II trial.

The cortico-cortical paired associative stimulation, a combined stimulation based on two brain regions, may be an effective strategy for stroke rehabilitation. Our aim was to confirm that the cortico-cortical paired associative stimulation strengthens the connection between brain regions in the motor circuit and promotes improvements in motor function. This was a randomized double-blind, controlled Phase II trial.

Updates on Breast Reconstruction: Surgical Techniques, Challenges, and Future Directions.

The increasing global incidence of breast cancer underscores the significance of breast reconstruction in enhancing patients' quality of life. Breast reconstruction primarily falls into two categories: implant-based techniques and autologous tissue transfers. In this study, we present a comprehensive review of various aspects of implant-based reconstruction, including different types of implants, surgical techniques, and their respective advantages and disadvantages.

Correction to: Infection's Association With Decreased Risk of Breast Cancer.

[This corrects the article DOI: 10.14740/wjon1617.].

Earth Observation Data to Support Environmental Justice: Linking Non-Permitted Poultry Operations to Social Vulnerability Indices.

Concentrated Animal Feeding Operations (CAFOs) apply massive amounts of untreated waste to nearby farmlands, with severe environmental health impacts of swine CAFOs and proximity to disadvantaged communities well documented in some US regions. Most studies documenting the impacts of CAFOs rely almost exclusively on CAFO locations known from incomplete public records. Poultry CAFOs generate dry waste and operate without federal permits; thus, their environmental justice (EJ) impacts are undocumented.

A novel microRNA promotes coxsackievirus B4 infection of pancreatic β cells.

The epidemiological association of coxsackievirus B infection with type 1 diabetes suggests that therapeutic strategies that reduce viral load could delay or prevent disease onset. Moreover, recent studies suggest that treatment with antiviral agents against coxsackievirus B may help preserve insulin levels in type 1 diabetic patients. In the current study, we performed small RNA-sequencing to show that infection of immortalized trophoblast cells with coxsackievirus caused differential regulation of several miRNAs.

A Painful Reality Check? Examining the Accuracy of Subjective Survival Probabilities by Pain Interference and Depression Status.

Purpose: Pain and depression are linked to higher mortality risk and lower subjective survival probabilities (SSPs). We examine if SSPs for individuals with pain and depression match their actual lifespans.

Methods: Using data on 12,745 Health and Retirement Study respondents aged 57-89 in 2000 with follow-up through 2018, we assessed whether respondents' SSPs were "correct," "underestimated," or "overestimated" relative to their lifespans.

Evidence of cortical vascular impairments in early stage of Alzheimer's transgenic mice: Optical imaging.

Alzheimer's disease (AD), a neurodegenerative disorder with progressive cognitive decline, remains clinically challenging with limited understanding of etiology and interventions. Clinical studies have reported vascular defects prior to other pathological manifestations of AD, leading to the "Vascular Hypothesis" for the disorder. However, assessments of cerebral vasculature in AD rodent models have been constrained by limited spatiotemporal resolution or field of view of conventional imaging.

Evaluation of imputation performance of multiple reference panels in a Pakistani population.

Genotype imputation is crucial for genome-wide association studies (GWASs), but reference panels and existing benchmarking studies prioritize European individuals. Consequently, it is unclear which publicly available reference panel should be used for Pakistani individuals, and whether ancestry composition or sample size of the panel matters more for imputation accuracy. Our study compared different reference panels to impute genotype data in 1,814 Pakistani individuals, finding the best performance balancing accuracy and coverage with meta-imputation with TOPMed and the expanded 1000 Genomes (ex1KG) reference.

Mitochondria-targeted oligomeric α-synuclein induces TOM40 degradation and mitochondrial dysfunction in Parkinson's disease and parkinsonism-dementia of Guam.

Mitochondrial dysfunction is a central aspect of Parkinson's disease (PD) pathology, yet the underlying mechanisms are not fully understood. This study investigates the link between α-Synuclein (α-Syn) pathology and the loss of translocase of the outer mitochondrial membrane 40 (TOM40), unraveling its implications for mitochondrial dysfunctions in neurons. We discovered that TOM40 protein depletion occurs in the brains of patients with Guam Parkinsonism-Dementia (Guam PD) and cultured neurons expressing α-Syn proteinopathy, notably, without corresponding changes in TOM40 mRNA levels.

Is it time to Reassess The Role of Preoperative HypoalbuminemiaAmong Geriatric Distal Femur Fracture Patients?

Background: Hypoalbuminemia, blanketly defined as Albumin < 3.5 g/dL, is often utilized as a threshold associated with postoperative complications and mortality among orthopedic and non-orthopedic surgical procedures. Albumin level is influenced by a myriad of factors including liver function, malnutrition, and inflammation.

Perfluorooctanesulfonic acid (PFOS) removal from aqueous solution through N-doped porous copper-carbon composite derived from recycled copper obtained from fly ash incinerator: Water decontamination via municipal waste remnants.

Invincible growth in waste production is the consequence of overpopulation, which should be addressed to reduce the occupied landfill surface needed for their disposal and to alleviate the leachate of extremely hazardous material into the soil and water bodies. In this study, copper (Cu) was extracted from fly ash of a municipal solid waste incinerator by an electro-chemical method, which was optimized to recover the highest amount of Cu, and then it was chelated with 4-aminobenzoic acid (AM) and terephthalic acid (TM) in an aqueous phase. The obtained composites were then heated to form a porous calcinated copper-carbon composite and utilized to adsorb the forever contaminant of PFOS from aqueous solutions.

Computer modeling of bevacizumab drug distribution after intravitreal injection in rabbit and human eyes.

Age-related macular degeneration (AMD) is a progressive eye disease that causes loss of central vision and has no cure. Wet AMD is the late neovascular form treated with vascular endothelial growth factor (VEGF) inhibitors. VEGF is the critical driver of wet AMD.

Simultaneous Traumatic Fractures of the Atlas and Axis: Presentation, Management, and Outcomes from a Series of 103 Consecutive Patients.

Background: Simultaneous fractures of C1 and C2 are increasingly common, but contemporary series are limited in their evaluation.

Methods: All patients with traumatic fractures of both C1 and C2 admitted to an academic trauma center from 2012 to 2022 were retrospectively analyzed. Multivariable regression was used to identify characteristics relevant to management and outcomes.

Parallel mechanical computing: Metamaterials that can multitask.

Decades after being replaced with digital platforms, analogue computing has experienced a surging interest following developments in metamaterials and intricate fabrication techniques. Specifically, wave-based analogue computers which impart spatial transformations on an incident wavefront, commensurate with a desired mathematical operation, have gained traction owing to their ability to directly encode the input in its unprocessed form, bypassing analogue-to-digital conversion. While promising, these systems are inherently limited to single-task configurations.

A 13,000-year history of vegetation and fire in a rare inland pine barrens: The Albany Pine Bush (Albany County, New York, USA).

Two radiocarbon-dated pollen and charcoal records from cores collected at Stump Pond and a wetland in suburban Albany County, New York, provide new insights into the environmental history of a unique inland pine barrens that is currently surrounded and threatened by urban development: the Albany Pine Bush (APB). The Stump Pond core shows that the pond formed roughly 13,000 years ago with the recession of glacial Lake Albany. From ca.

Conformational dynamics of a nicotinic receptor neurotransmitter site.

Agonists enhance receptor activity by providing net-favorable binding energy to active over resting conformations, with efficiency (η) linking binding energy to gating. Previously, we showed that in nicotinic receptors, η-values are grouped into five structural pairs, correlating efficacy and affinity within each class, uniting binding with allosteric activation (Indurthi and Auerbach, 2023). Here, we use molecular dynamics (MD) simulations to investigate the low-to-high affinity transition (L→H) at the Torpedo α-δ nicotinic acetylcholine receptor neurotransmitter site.

Association of Cognitive Symptoms and Abnormal Oculomotor Signs With Recovery in Adolescents After Sport-Related Concussion.

Objective: Sport-related concussion (SRC) affects cognitive and oculomotor function. We evaluated recovery from SRC in athletes with cognitive symptoms and/or oculomotor impairments who were prescribed early aerobic exercise treatment.

Design: Secondary exploratory analysis of a randomized controlled trial.