Computational docking of FtsZ: Survey of promising antibiotic compounds.

The bacterial cell-division protein FtsZ has been a promising antibiotic target for over a decade now, but there is still a need for more work in this area. So far there are no FtsZ targeting drugs commercially available. We have analyzed a wide variety of prospective drugs and their interactions with multiple FtsZ species using both free and directed docking simulations.

Post-Sterilization Physicochemical Characterization and Biological Activity of Cellulose Nanocrystals Coated with PDDA.

The rapid expansion of medical nanotechnology has significantly broadened the potential applications of cellulose nanocrystals (CNCs). While CNCs were initially developed for drug delivery, they are now being investigated for a range of advanced biomedical applications. As these applications evolve, it becomes crucial to understand the physicochemical behavior of CNCs in biologically relevant media to optimize their design and ensure biocompatibility.

Draft genome sequence of sp. ABKF26, a potential petroleum, plastic, and rubber-degrading bacterium, isolated from St. Albans Bay, VT, USA.

Here, we present the draft genome sequence of sp. ABKF26, a potential petroleum, plastic, and rubber degrading bacterium isolated from Lake Champlain. The assembled genome comprises a 6.

Genome sequence of RI06-95 isolated during a bloom in lake Champlain, USA.

Here, we present the complete genome sequence of RI06-95 isolated during a bloom in Lake Champlain. The assembled genome comprises a 3.8 Mbp chromosome with a GC content of 42%, and two plasmids, pPZZ84 6.

Post-stroke deficits in the anticipatory control and bimanual coordination during naturalistic cooperative bimanual action.

Background: Unilateral stroke leads to asymmetric deficits in movement performance; yet its effects on naturalistic bimanual actions, a key aspect of everyday functions, are understudied. Particularly, how naturalistic bimanual actions that require the two hands to cooperatively interact with each other while manipulating a single common object are planned, executed, and coordinated after stroke is not known. In the present study, we compared the anticipatory planning, execution, and coordination of force between individuals with left and right hemisphere stroke and neurotypical controls in a naturalistic bimanual common-goal task, lifting a box.

In vitro immune and redox response induced by cationic cellulose-based nanomaterials.

Cellulose nanocrystals (CNCs) display remarkable strength and physicochemical properties with significant potential applications. To better understand the potential adjuvanticity of a nanomaterial, it is important to investigate the extent of the immunological response, the mechanisms by which they elicit this response, and how this response is associated with their physicochemical characteristics. In this study, we investigated the potential mechanisms of immunomodulation and redox activity of two chemically related cationic CNC derivatives (CNC-METAC-1B and CNC-METAC-2B), using human peripheral blood mononuclear cells and mouse macrophage cells (J774A.

Recent advances in cellulose nanocrystals-based antimicrobial agents.

Over the past five years, there has been growing interest in the design of modified cellulose nanocrystals (CNCs) as nanoscale antimicrobial agents in potential end-user applications such as food preservation/packaging, additive manufacturing, biomedical and water purification. The interest of applying CNCs-based antimicrobial agents arise due to their abilities to be derived from renewable bioresources and their excellent physicochemical properties including rod-like morphologies, large specific surface area, low toxicity, biocompatibility, biodegradability and sustainability. The presence of ample surface hydroxyl groups further allows easy chemical surface modifications for the design of advanced functional CNCs-based antimicrobial materials.

The Effect of a Strength and Conditioning Protocol on NCAA Division 1 Women's Basketball Players' Mental Toughness.

Mental toughness (MT) is a popularized term in sports since it has been found to be positively related to performance. Self-assessment is the most common method of MT data collection. In the strength and conditioning (S&C) context, MT research has focused on males with a notable lack of female participants.

Carboxylated Cellulose Nanocrystals Decorated with Varying Molecular Weights of Poly(diallyldimethylammonium chloride) as Sustainable Antibacterial Agents.

Cationic nanomaterials are promising candidates for the development of effective antibacterial agents by taking advantage of the nanoscale effects as well as other exceptional physicochemical properties of nanomaterials. In this study, carboxylated cellulose nanocrystals (cCNCs) derived from softwood pulp were coated with cationic poly(diallyldimethylammonium chloride) of varying molecular weights. The resulting cationic carboxylated cellulose nanocrystals coated with poly(diallyldimethylammonium chloride) (cCNCs-PDDA) nanomaterials were characterized for their structural and morphological properties using Fourier transform infrared spectroscopy, dynamic light scattering, zeta potential, elemental analysis, transmission electron microscopy, and thermogravimetric analysis.

Changes in health with the rise of industry.

Since the publication of the Christ Church Spitalfields crypt, London, in 1993, archaeologists and paleopathologists have increasingly recognized the importance of post-medieval burial assemblages. Increasingly paleopathologists have explored the impact industrialization and urbanization had on disease. This virtual special issue focuses upon a global examination of the transition to industry commencing in the mid-18th century.

The Effect of COVID-19 on Domestic Violence and Assaults.

The purpose of this research was to examine the effect of COVID-19 on four outcomes including calls for service for domestic violence, calls for service for assaults, arrests for domestic violence, and arrests for assaults in Burlington, Vermont. The data for each outcome collected over the time periods January 2012 through May 2021 were obtained from the Burlington Police Department website and then a monthly time-series data set were created. The analyses including an independent samples t-test, a Poisson regression test, and a monthly interrupted time-series analyses (ITSA) were employed to test the effects of COVID-19 on the previously mentioned outcomes.

The dark satanic mills: Evaluating patterns of health in England during the industrial revolution.

Objective: this research seeks to investigate the impact the industrial revolution had on the population of England.

Materials: Pre-existing skeletal data from 1154 pre-Industrial (1066-1700 CE) and 4157 industrial (1700-1905) skeletons from 21 cemeteries (N = 5411).

Methods: Context number, sex, age-at-death, stature and presence/absence of selected pathological conditions were collated.

Mechanisms that underlie blood flow regulation at rest and during exercise.

The cardiovascular system must distribute oxygen and nutrients to the body while maintaining appropriate blood pressure. This is achieved through a combination of central and peripheral mechanisms that influence cardiac output and vasomotor tone throughout the vascular system. Furthermore, the capability to preferentially direct blood to tissues with increased metabolic demand (i.

Developing a guideline for measuring workplace non-Gaussian noise exposure based on kurtosis adjustment of noise level in China.

Objective: There is no unified standard for measuring workplace non-Gaussian noise (known as complex noise) exposure. This study aimed to develop a draft guideline for measuring workplace non-Gaussian complex noise exposure based on noise temporal structure adjustment.

Methods: Noise exposure level, e.

Synthesis, Applications and Biological Impact of Nanocellulose.

Interest in cellulose-based nanomaterials has continued to increase dramatically in the past few years, especially with advances in the production routes of nanocellulose-such as cellulose nanocrystals (CNC), cellulose nanofibrils (CNF) and bacterial nanocellulose (BNC)-that tailor their performances [...

No effect of occupational noise exposure on auditory brainstem response and speech perception in noise.

The primary aim of this study was to investigate whether auditory brainstem response (ABR) and speech perception in noise (SPiN) were associated with occupational noise exposure in normal hearing young factory workers. Forty young adults occupationally exposed to noise and 40 non-exposed young adults (control group) from Zhejiang province in China were selected. All participants presented with normal hearing thresholds and distortion product otoacoustic emissions.

Seropositivity Interacts with Catechol--methyltransferase Val105/158Met Variation Increasing the Risk of Schizophrenia.

Schizophrenia is a heterogeneous and severe psychotic disorder. Epidemiological findings have suggested that the exposure to infectious agents such as Toxoplasma gondii (T. gondii) is associated with an increased risk for schizophrenia.

Estimation of Occupational Noise-Induced Hearing Loss Using Kurtosis-Adjusted Noise Exposure Levels.

Objectives: Studies have shown that in addition to energy, kurtosis plays an important role in the assessment of hearing loss caused by complex noise. The objective of this study was to investigate how to use noise recordings and audiometry collected from workers in industrial environments to find an optimal kurtosis-adjusted algorithm to better evaluate hearing loss caused by both continuous noise and complex noise.

Design: In this study, the combined effects of energy and kurtosis on noise-induced hearing loss (NIHL) were investigated using data collected from 2601 Chinese workers exposed to various industrial noises.

Enhancing Microbiome Research through Genome-Scale Metabolic Modeling.

Construction and analysis of genome-scale metabolic models (GEMs) is a well-established systems biology approach that can be used to predict metabolic and growth phenotypes. The ability of GEMs to produce mechanistic insight into microbial ecological processes makes them appealing tools that can open a range of exciting opportunities in microbiome research. Here, we briefly outline these opportunities, present current rate-limiting challenges for the trustworthy application of GEMs to microbiome research, and suggest approaches for moving the field forward.

Using as a Model for Ciliopathies.

has served as a model organism for the studies of many aspects of genetics and cell biology: non-Mendelian inheritance, genome duplication, genome rearrangements, and exocytosis, to name a few. However, the large number and patterning of cilia that cover its surface have inspired extraordinary ultrastructural work. Its swimming patterns inspired exquisite electrophysiological studies that led to a description of the bioelectric control of ciliary motion.

Cross-cultural neuropsychological assessment in Europe: Position statement of the European Consortium on Cross-Cultural Neuropsychology (ECCroN).

Over the past decades European societies have become increasingly diverse. This diversity in culture, education, and language significantly impacts neuropsychological assessment. Although several initiatives are under way to overcome these barriers - e.

The Role of the Kurtosis Metric in Evaluating the Risk of Occupational Hearing Loss Associated with Complex Noise - Zhejiang Province, China, 2010-2019.

What Is Already Known About This Topic?: Occupational noise-induced hearing loss (NIHL) has been the second most common occupational disease in China. Noise energy is the main risk factor for occupational NIHL. Evidence shows the temporal structure of noise (as indicated by kurtosis metric) contribute to the development of NIHL.

Vascular and Blood Compatibility of Engineered Cationic Cellulose Nanocrystals in Cell-Based Assays.

An emerging interest regarding nanoparticles (NPs) concerns their potential immunomodulatory and pro-inflammatory activities, as well as their impact in the circulatory system. These biological activities of NPs can be related to the intensity and type of the responses, which can raise concerns about adverse side effects and limit the biomedical applicability of these nanomaterials. Therefore, the purpose of this study was to investigate the impact of a library of cationic cellulose nanocrystals (CNCs) in the human blood and endothelial cells using cell-based assays.