Apology for the publication of Sheng et al. (2024).

Recently, published Sheng et al.'s (see record 2024-72017-001) article titled "The Development of Tibetan Children's Racial Bias in Empathy: The Mediating Role of Ethnic Identity and Wrongfulness of Ethnic Intergroup Bias." The article went through the standard peer review process.

An approach for in-situ detection of gold colloid aggregates amyloid formations within the hippocampus of the Cohen's Alzheimer's disease rat model by surface enhanced raman scattering methods.

Background: Amyloid beta (Aβ) peptides, such as Aβ or Aβ are regarded as hallmark neuropathological biomarkers associated with Alzheimer's disease (AD). The formation of an aggregates by Aβ or Aβ-coated gold nano-particles are hypothesized to contain conformation of Aβ oligomers, which could exist only at an initial stage of fibrillogenesis.

New Method: The attempt of in-situ detection of externally initiated gold colloid (ca.

Validity of a Computational Linguistics-Derived Automated Health Literacy Measure Across Race/Ethnicity: Findings from The ECLIPPSE Project.

Limited health literacy (HL) partially mediates health disparities. Measurement constraints, including lack of validity assessment across racial/ethnic groups and administration challenges, have undermined the field and impeded scaling of HL interventions. We employed computational linguistics to develop an automated and novel HL measure, analyzing >300,000 messages sent by >9,000 diabetes patients via a patient portal to create a Literacy Profiles.

Structural Disadvantage and Culture, Race, and Ethnicity in Early Psychosis Services: International Provider Survey.

Objective: Little is known about provider perspectives on programmatic responses to structural disadvantage and cultural differences within early intervention in psychosis (EIP) services, programs, and models. The primary objective of this study was to investigate providers' perspectives on the impacts of disadvantage and minority race, ethnicity, and culture and to describe current practices and perceived gaps and concerns.

Methods: An online survey of specialized EIP providers was disseminated in the United Kingdom, United States, Canada, Australia, and Chile.

Challenges and solutions to employing natural language processing and machine learning to measure patients' health literacy and physician writing complexity: The ECLIPPSE study.

Objective: In the National Library of Medicine funded ECLIPPSE Project (Employing Computational Linguistics to Improve Patient-Provider Secure Emails exchange), we attempted to create novel, valid, and scalable measures of both patients' health literacy (HL) and physicians' linguistic complexity by employing natural language processing (NLP) techniques and machine learning (ML). We applied these techniques to > 400,000 patients' and physicians' secure messages (SMs) exchanged via an electronic patient portal, developing and validating an automated patient literacy profile (LP) and physician complexity profile (CP). Herein, we describe the challenges faced and the solutions implemented during this innovative endeavor.

Cooking Up Energy: A Culinary Education Program for Children with Parent Outreach.

Culinary interventions show promise in preventing obesity. The (CUE) program aimed to improve weight status and attitudes held about healthy foods, as well as increase cooking self-efficacy and frequency of meal preparation, in children 6-12 years of age. We provided 10 one-hour long culinary and nutrition education sessions.

Chuukese Patients, Dual Role Interpreters, and Confidentiality: Exploring Clinic Interpretation Services for Reproductive Health Patients.

This exploratory study analyzes limited English proficient (LEP) Chuukese patients' perspectives on dual-role interpreters in Guam and Chuuk. Methods included ethnographic observations of encounters with health care workers (HCWs) and 225 female Chuukese patients seeking reproductive healthcare in community health clinics: 126 women in Guam and 99 women in Chuuk. Ethnographic observations were supplemented by semi-structured interviews with 26 HCWs, and life history interviews with 15 Chuukese transnational migrant women.

Disruptive patterns of eating behaviors and associated lifestyles in males with ADHD.

Background: Attention deficit hyperactivity disorder (ADHD) is a neurological/behavioral disorder characterized by inattention or hyperactivity and impulsivity, or combined symptomatology. Children with ADHD are predisposed to irregular and/or impulsive eating patterns often leading to compromised physical condition. The goal of the present study was to statistically evaluate parental scoring of patterned eating behaviors and associated lifestyles within a cohort of 100 boys diagnosed with ADHD in comparison to age-matched male controls.

Morphine modulation of the ubiquitin-proteasome complex is neuroprotective.

Background: Over the past several decades, there is a growing need for the development of neuroprotective compounds, e.g, those that can prevent neural death. It was proposed that nitric oxide (NO), when induced by morphine, would produce neuroprotection in a human neuroblastoma cell line when tested concomitantly with compounds that produce intracellular oxidative stress and neuroinflammation.

The nongenomic protective effects of estrogen on the male cardiovascular system: clinical and therapeutic implications in aging men.

Although the preponderance of studies investigating the effects of estrogen on vasomotor tone and function have focused on women, a number of recent studies have intriguingly shown that estrogen's rapid vasodilatory properties is also preserved in men. Unlike classical steroid transcription mediated pathways, estrogen's acute vasodilatory effect is mediated by calcium dependent cell surface estrogen receptors that stimulate constitutive endothelial nitric oxide synthase (eNOS) activity. The transient release of eNOS derived nitric oxide exerts profound physiological effects on the vasculature exerting a state of cellular inhibition (i.

Cell surface estrogen receptors coupled to cNOS mediate immune and vascular tissue regulation: therapeutic implications.

The vast number of reports dealing with estrogen and its associated molecular signaling cascades deal with genomic processes. However, recently data is emerging that demonstrates that estrogen may also work via estrogen cell surface receptors. In this regard, we describe such receptors on human monocytes, granulocytes and vascular endothelial cells.

Tenidap and flurbiprofen enhance uptake of matrix metalloproteinase inhibitor 4-dedimethylaminotetracycline in inflamed joints of adjuvant arthritic rats.

Objective: To identify a mechanism by which a matrix metalloproteinase (MMP) inhibitor might act synergistically with other agents to decrease MMP activity and thereby lessen the radiologic severity of adjuvant arthritis.

Methods: Rats with adjuvant arthritis were treated with either flurbiprofen (FBP) or tenidap (TDP), along with 4-dedimethylaminotetracycline (CMT-1), a potent MMP inhibitor. Indices of inflammatory severity and of radiologic destruction were assessed and compared to serum and bone levels of the MMP inhibitor.

Degradation of Met-enkephalin by hemolymph peptidases in Mytilus edulis.

1. Met-enkephalin is degraded by peptidases present in the hemolymph fluid and hemocyte membrane suspension of Mytilus edulis. Degradation of Met-enkephalin is rapid in the fluid and slower in the membrane.

Soluble and membrane-bound Met-enkephalin degrading peptidases in Mytilus edulis hemolymph.

Recent reports have provided strong evidence indicating that Met-enkephalin is serving as a neuroimmune modulator. It acts as a bidirectional signal molecule in transmitting message between the endocrine system and the immune cells in the circulating fluid. In this study, we investigated peptidases which are capable of degrading Met-enkephalin in the hemolymph fluid and hemocyte membrane.

Presence of enkephalin precursor in molluscan neural tissue extract.

Mytilus pedal ganglia extract was treated sequentially with TPCK-trypsin and carboxypeptidase B. The treated sample and an untreated sample were purified separately with Sep-Pak C18 and subjected to HPLC. Fractions with Rt's corresponding to the Met-, Leu-enkephalin and Met-enkephalin-Arg6-Phe7 were assayed for enkephalin activities by displacement studies using pedal ganglia membrane and 3H-DAMA.