Syngeneic B16F10 Melanoma Causes Cachexia and Impaired Skeletal Muscle Strength and Locomotor Activity in Mice.

Muscle wasting has been emerging as one of the principal components of cancer cachexia, leading to progressive impairment of work capacity. Despite early stages melanomas rarely promotes weight loss, the appearance of metastatic and/or solid tumor melanoma can leads to cachexia development. Here, we investigated the B16F10 tumor-induced cachexia and its contribution to muscle strength and locomotor-like activity impairment.

Moderate Treadmill Exercise Training Improves Cardiovascular and Nitrergic Response and Resistance to Infection in Mice.

There is evidence suggesting that exercise training (ET) acts as a factor toward resistance to infection. However, the effects of mean arterial pressure (MAP), heart rate (HR), and nitric oxide (NO) during the acute phase of infection has not been elucidated yet. Swiss mice were randomly assigned into four groups: sedentary control (SC, = 30), trained control (TC, = 30), sedentary infected (SI, = 30), and trained infected (TI, = 30).