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Background: Chromoblastomycosis is a chronic cutaneous fungal infection where the presence of fibrous scars and continuous inflammation might be the propitious condition for the development of malignant neoplasms.

Methods: We report a case of cutaneous melanoma arising on a leg of a man that had been affected by extensive chromoblastomycosis for more than 30 years.

Results: A 70-year-old white man presented with an irregularly pigmented lesion over an area of fibrosis and verrucous lesions, previously diagnosed as chromoblastomycosis, on his left ankle.

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