2,636 results match your criteria: "State University of Campinas UNICAMP[Affiliation]"

can cause invasive pulmonary aspergillosis (IPA). Fungicidal azoles and fungistatic caspofungin (CAS) are the first- and second-line therapies, respectively, used to treat IPA. Treatment of with CAS or micafungin induces the production of the oxylipin 5,8-diHODE by the fungal oxygenase PpoA.

View Article and Find Full Text PDF

Cystic fibrosis (CF) affects not just patients but also their families, highlighting the need for a comprehensive care approach. This descriptive qualitative study aimed to explore the informational needs of family caregivers of children with CF, focusing on how these needs can be addressed within a Patient and Family-Centered Care (PFCC) framework. The study was conducted at a public hospital in Brazil.

View Article and Find Full Text PDF

Classification of pediatric soft and bone sarcomas using DNA methylation-based profiling.

BMC Cancer

November 2024

Research Center, Boldrini Children's Hospital, Rua Marcia Mendes, 619, Cidade Universitaria, CEP 13083-884, Campinas, São Paulo, Brazil.

Pediatric sarcomas present heterogeneous morphology, genetics and clinical behavior posing a challenge for an accurate diagnosis. DNA methylation is an epigenetic modification that coordinates chromatin structure and regulates gene expression, determining cell type and function. DNA methylation-based tumor profiling classifier for sarcomas (known as sarcoma classifier) from the German Cancer Research Center (Deutsches Krebsforschungszentrum) was applied to 122 pediatric sarcomas referred to a reference pediatric oncology hospital.

View Article and Find Full Text PDF

Human oncogenic viruses: a focus on head and neck carcinogenesis: a systematic review and meta-analysis.

Oral Surg Oral Med Oral Pathol Oral Radiol

October 2024

Department of Oral Diagnosis, Semiology and Oral Pathology Areas, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil. Electronic address:

Article Synopsis
  • This systematic review investigated the connection between oncoviruses and head and neck cancers (HNC).
  • Researchers analyzed studies from five databases and assessed their reliability using established guidelines.
  • The findings revealed a significant relationship between certain oncoviruses, particularly HPV-16, HPV-18, and Epstein-Barr virus, and the development of HNC, while further research is needed on other viruses like human cytomegalovirus and Merkel Cell Polyomavirus.
View Article and Find Full Text PDF

Background: Some odontogenic cysts (OCs) and odontogenic tumors (OTs) are infiltrative and often recur, causing bone destruction and tooth loss. In the elderly, in particular, these injuries cause significant morbidity, making rehabilitation difficult and compromising the quality of life of these individuals. Objective: To determine the prevalence and demographic characteristics of OCs, non-odontogenic cysts (NOCs), and OTs diagnosed in an elderly Brazilian population (≥60 years).

View Article and Find Full Text PDF

Introduction: Among the wide variety of commercially oral hygiene products, activated charcoal-based toothpastes have irrupted the market, claiming multiple benefits. Although most are fluoride free, others incorporate fluoride into their formulations, yet the chemical availability and stability of fluoride in these products remain unclear. Our study aimed to assess the chemical availability and stability of fluoride in commercially fluoridated toothpastes formulated with activated charcoal.

View Article and Find Full Text PDF
Article Synopsis
  • A study evaluated how inflammation impacts the choice between standard and customized parenteral nutrition (PN) for hospitalized adolescents in Brazil, focusing on individual clinical and nutritional needs.
  • Out of 61 teens analyzed, 128 PN solutions were prescribed, with a majority requiring customization mainly to restore energy-protein adequacy.
  • The findings suggested that addressing malnutrition and inflammation through customized PN is essential for improving nutritional status and reducing further adjustments needed during treatment.
View Article and Find Full Text PDF

Background/objectives: Depression, anxiety, and stress are highly prevalent mental disorders worldwide, and food consumption can change in individuals with these conditions. We aimed to assess the food consumption of women with depressive symptoms and compare it to a control without symptoms.

Methods: A cross-sectional study was conducted with 96 women, aged 18-59, allocated into two groups: control = 62) or depressive symptoms ( = 34).

View Article and Find Full Text PDF

Spray paint-derived microplastics and incorporated substances as ecotoxicological contaminants in the neotropical bumblebee Bombus atratus.

Environ Toxicol Pharmacol

December 2024

Federal University of São Carlos (UFSCar), Department of Biology (DBio-So), Laboratory of Structural and Functional Biology (LABEF), Brazil; Post-graduate Program in Biotechnology and Environmental Monitoring (PPGBMA), Center for Science and Technology for Sustainability (CCTS), UFSCar, Sorocaba, SP, Brazil.

While bumblebees may be exposed to microplastics (MPs), the effects on them are not well studied. Therefore, in this research, we assessed the cytotoxicity of pristine and photodegraded spray paint-derived MPs on the midgut, Malpighian tubules, and hepato-nephrocitic system cells of Bombus atratus workers exposed to 50 mg.L MPs for 96 hours.

View Article and Find Full Text PDF

Unlabelled: Β-glucosidase (BGLs) act synergistically with endoglucanases and exoglucanases and then are of great interest for biomass conversion into bioethanol. Thus, the aim of the current study is to produce a recombinant β-glycosidase from expressed in cells. Enzyme coding sequence expression was confirmed through Sanger sequencing after using wheat bran (WB) and carboxymethylcellulose (CMC) as fungal growth media.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the role of the mitochondrial protein NNT in obesity-related metabolic issues, using a specific mouse model lacking NNT genetic material.
  • Unlike previous studies, this research utilized a high-fat diet (45% calories from fat) that better represents typical fat-rich diets compared to the usual 60%.
  • Results show that mice without NNT gained less weight on a high-fat diet but had poorer glucose tolerance, while also revealing an increase in brown adipose tissue mass and inflammatory markers in the hypothalamus associated with diet-induced inflammation.
View Article and Find Full Text PDF

Engineering cellular redox homeostasis to optimize ethanol production in xylose-fermenting Saccharomyces cerevisiae strains.

Microbiol Res

January 2025

State University of Campinas (Unicamp), Genetics and Molecular Biology Graduate Program, Institute of Biology, Campinas, São Paulo 13083-862, Brazil. Electronic address:

The transition from fossil fuels dependency to embracing renewable alternatives is pivotal for mitigating greenhouse gas emissions, with biorefineries playing a central role at the forefront of this transition. As a sustainable alternative, lignocellulosic feedstocks hold great promise for biofuels and biochemicals production. However, the effective utilization of complex sugars, such as xylose, remains a significant hurdle.

View Article and Find Full Text PDF

Telocytes of the male reproductive system: dynamic tissue organizers.

Front Cell Dev Biol

October 2024

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, Brazil.

Telocytes are CD34 interstitial cells that have long cytoplasmic projections (called telopodes), and have been detected in several organs, including those of the male reproductive system. In this brief review we evaluate the role of telocytes in tissue organization of the different organs of the male reproductive system in which these cells were studied. In general terms, telocytes act in the tissue organization through networks of telopodes that separate the epithelia from the stroma, as well as dividing the stroma into different compartments.

View Article and Find Full Text PDF

Objective: This study aimed to explore the utility of a high-intensity interval training (HIIT) app as a remote exercise support strategy in children with obesity through assessing adherence, possible effects on obesity-related outcomes, and perceptions of its use to support counseling and improve the treatment of children with obesity.

Methods: Thirty-seven children (94.6% with obesity; 45.

View Article and Find Full Text PDF

Individual and combined effects of commercial glyphosate, atrazine and 2,4-D herbicides on the gerbil ventral prostate.

Chemosphere

November 2024

Department of Biological Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), São José do Rio Preto, São Paulo, Brazil. Electronic address:

Exposure to pesticides, individually or in a mixture, in drinking water is one of the main sources of human contamination, which causes adverse effects on the reproductive system. Our study aimed to investigate, the effects of a 90-day exposure to low concentrations of glyphosate (GLY), atrazine (ATZ), and 2,4-dichlorophenoxyacetic acid (2,4-D), in commercial formulations, on morphological, molecular, and hormonal parameters of the ventral prostate of gerbils (Meriones unguiculatus). The animals were exposed via drinking water to individual concentrations of GLY: 700 μg/L, ATZ: 3 μg/L, and 2,4-D: 70 μg/L, as well as to their mixture (MIX).

View Article and Find Full Text PDF

SDIMMMER is an acronym intended for use in both clinical practice and medical research. It facilitates a comprehensive evaluation of a patient's metabolic profile and serves as a mnemonic for the following key assessment areas: Sleep, Diet, Microbiome, Metabolism, Medications, Exams, and Rehabilitation. In the clinical setting, SDIMMMER's primary objective is to monitor and manage the patient's metabolic status, particularly targeting low-grade chronic systemic inflammation, a hallmark of metabolic syndrome (MS).

View Article and Find Full Text PDF

The ability of plants to recover after stressful events is crucial for resuming growth and development and is a key trait when studying stress tolerance. However, there is a lack of information on the physiological responses and the time required to restore homeostasis after the stress experience. This study aimed to (i) enhance understanding of soybean photosynthesis performance during saline waterlogging and (ii) investigate the effects of this combined stress during the reoxygenation and recovery period.

View Article and Find Full Text PDF

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is linked to high mortality, primarily through an intense inflammatory response. Diacerein has emerged as a potential therapy for COVID-19 due to its potential impact in decreasing the inflammasome activation and coronavirus replication. This study aims to explore diacerein's influence in inhibiting both viral replication and the inflammatory response after SARS-CoV-2 infection.

View Article and Find Full Text PDF

Obesity is a complex chronic disease that affects millions of people worldwide. There is still significant stigma associated with it, which can lead to discrimination and create additional barriers for people who are already in treatment. On the other hand, it is noted that it can have serious implications for health and predisposition to noncommunicable chronic diseases.

View Article and Find Full Text PDF

Consumers have been demanding foods that, besides providing nutrition, bring some health benefits, known as functional foods. The insertion of probiotics in foods is a strategy for developing functional foods. Still, it has been a challenge because these matrices have different pHs and undergo different process temperatures and times that can reduce the viability of these microorganisms.

View Article and Find Full Text PDF

Women's mental health and COVID-19: increased vulnerability and inequalities.

Front Glob Womens Health

October 2024

Latin American Center for Perinatology, Women and Reproductive Health, Pan American Health Organization (PAHO), Montevideo, Uruguay.

Introduction: The impact of COVID-19 on mental health has become a relevant object of research. Studies have demonstrated that women have experienced greater mental health challenges, highlighting the importance of public health systems to address women's specific needs.

Methods: This literature review explores the effects of the coronavirus pandemic on psychological distress among women, aiming to provide a comprehensive understanding of the subject and to explore how these research findings can guide public mental health care responses in crisis settings.

View Article and Find Full Text PDF