Hepatocyte nuclear factor 4-α is necessary for high fat diet-induced pancreatic β-cell mass expansion and metabolic compensations.

Aims: This study investigates the role of Hepatocyte Nuclear Factor 4α (HNF4α) in the adaptation of pancreatic β-cells to an HFD-induced obesogenic environment, focusing on β cell mass expansion and metabolic adaptations.

Main Methods: We utilized an HNF4α knockout (KO) mouse model, with CRE-recombinase enzyme activation confirmed through tamoxifen administration. KO and Control (CTL) mice were fed an HFD for 20 weeks.

Molecular evidence of Wolbachia in bat-associated mite Periglischrus Iheringi Oudemans, 1902 (Mesostigmata: Spinturnicidae) from Brazil.

Wolbachia is an intracellular endosymbiont bacterium found in nematodes and arthopods. Regarding mites, the Wolbachia supergroup U has been described based on strains found in the genus Spinturnix. In this study, ten specimens of Periglischrus iheringi (Mesostigmata: Spinturnicidae), collected from Artibeus obscurus (Chiroptera: Phyllostomidae) in Santa Catarina State, were found to be infected with Wolbachia.

Impact of body composition and muscle health phenotypes on survival outcomes in colorectal cancer: a multicenter cohort.

Body composition abnormalities are prognostic markers in several types of cancer, including colorectal cancer (CRC). Using our data distribution on body composition assessments and classifications could improve clinical evaluations and support population-specific opportune interventions. This study aimed to evaluate the distribution of body composition from computed tomography and assess the associations with overall survival among patients with CRC.

A retrospective description of blood and urine alterations in 386 male cats with urethral obstruction in Botucatu, São Paulo, Brazil.

Background: Urinary retention in obstructed male cats leads to changes in blood and urine compounds, which, combined with the time of obstruction, are linked to the worsening of the animal's clinical status.

Aim: This study aimed to describe the primary laboratory changes in male cats with urethral obstruction (UO).

Methods: Medical records of 386 male cats diagnosed with UO and treated at the Veterinary Teaching Hospital of the Faculty of Veterinary Medicine and Zootechnics (FMVZ), UNESP-Botucatu, between 2010 and 2020 were reviewed.

Natural indigo toxicity for aquatic and terrestrial organisms.

Indigo is a widely used colorant available from natural and synthetic origin. It is practically insoluble in water. Indigo can reach aquatic sediments through wastewater discharges from dyeing processes, terrestrial compartments from the treatment sludges used as biosolids and dyed textiles disposed in landfills.

Effects of Platelet-Rich Fibrin on Bone Healing Around Implants Placed in Maxillary Sinuses: A Histomorphometric Assessment in Rabbits.

This study investigated the effect of platelet-rich fibrin (PRF) on bone healing around implants placed in elevated sinus cavities. Forty New Zealand albino rabbits were divided into eight groups, based on the time of sacrifice (14 or 40 days) and the material used: blood clot (control), hydroxyapatite (HA) from bovine bone, HA combined with PRF, and PRF alone. Each group consisted of five animals (n = 5).

Is There an Ideal Concentration of Ozonized Oil for the Prevention and Modulation of Zoledronate-Induced Mandibular Osteonecrosis? A Study on Senescent Rats.

This study aimed to identify whether there is an ideal concentration for applying ozonized oil (OZ) in the post-exodontic alveoli of senescent rats treated with zoledronate (ZOL). Thirty-five female rats, aged 18 months, were divided into five groups: ZOL; ZOL+OZ500; ZOL+OZ600; ZOL+OZ700; and SAL. The groups treated with ZOL, and other concentrations of OZ received applications at a dose of 100 μg/kg, while the SAL group received saline.

Study of the synergistic properties of copaiba oil co-electrospun with poly(L-co-D,L lactic acid) and natural rubber latex for application in bioactive wound dressings.

Wound healing is a complex process involving a sequence of factors that can be disrupted, negatively impacting the quality of life for patients and overburdening healthcare systems. Advanced dressings obtained by electrospinning are highlighted by the optimization of this process, allowing air exchange and protection against microorganisms. Aiming to develop bioactive dressings, this study investigated the physicochemical, mechanical, microbiological, and in vitro biological properties of membranes containing 25 %, 50 %, 75 %, and 90 % copaiba oil (CO) co-electrospun with poly(L-co-D,L-lactic acid) (PLDLA) and natural rubber latex (NR).

Fermi Polaron in Atom-Ion Hybrid Systems.

Atom-ion hybrid systems are promising platforms for the quantum simulation of polaron physics in certain quantum materials. Here, we investigate the ionic Fermi polaron, a charged impurity in a polarized Fermi bath, at zero temperature using quantum Monte Carlo techniques. We compute the energy spectrum, residue, effective mass, and structural properties.

Exploring the ventricular morphology of the heart of Brycon amazonicus (Agassiz, 1829) (Teleostei, Characiformes).

Brycon amazonicus, a fish species widely distributed along freshwater rivers in Latin America, is important in maintaining ecological balance. Although some morphological/physiological aspects of B. amazonicus have been reported, the cardiac histomorphology of this species remains poorly understood.

Dentoskeletal effects of miniscrew-anchored maxillary protraction: Evaluating the role of mandibular anchorage bar and night facemask.

Introduction: This study evaluated the dentoskeletal effects of miniscrew-anchored maxillary protraction, which included a mandibular anchorage bar and a night facemask in adolescents.

Methods: A total of 20 growing patients with Class III malocclusion and maxillary deficiency were treated with a hybrid hyrax expander with 2 miniscrews in the maxilla and a mandibular anchor bar supported in 2 miniscrews in the anterior region of the mandible. Class III elastics were used from the maxillary first molars to the mandibular anchorage bar, joining the mandibular miniscrews installed between permanent incisors and canines.

Physical Demands of Brazilian Air Force Critical Combat Tasks.

Introduction: The present study aimed to identify the physical demands of Brazilian Air Force (BAF) critical Combat Tasks (CTs) and investigate the occurrence of differences in their difficulty perceived ratings, considering aspects such as sex, military experience, and academic degree of the evaluators.

Methods: The Subject Matter Expert (SME) cohort was assembled based on the BAF's Physical Training Specialists (n = 13, military, at least 2 years of experience). Based on the BAF's previous studies, a questionnaire defining and rating the physical demands of 12 BAF critical CTs was developed.

Dapagliflozin reduces the white coat effect on systolic blood pressure of patients with type 2 diabetes: a analysis from the ADDENDA-BHS 2 trial.

Background: White coat effect (WCE) is a phenomenon linked to increased cardiovascular risk, where office blood pressure readings exceed home or ambulatory measurements. Excess weight and elevated blood pressure or glucose are associated with WCE in type 2 diabetes (T2D). This study compared dapagliflozin and glibenclamide on WCE in T2D patients under equivalent blood pressure and glucose control.

Interplay between miRNA expression and glucose metabolism in oral squamous cell carcinoma.

Objective: Given the urgent need for improved diagnostic and therapeutic strategies in oral squamous cell carcinoma (OSCC), this review aims to explore the intricate interplay between OSCC and alterations in glucose metabolism, with a particular focus on the pivotal role of microRNAs (miRNAs) in this context.

Material And Methods: Data were extracted from a vast literature survey by using PubMed, Embase, and Web of Science search engines with relevant keywords.

Results: In OSCC, miRNAs exert regulatory control over the expression of genes involved in glucose metabolism pathways.

Identifying candidate genes for sugar accumulation in sugarcane: an integrative approach.

Background: Elucidating the intricacies of the sugarcane genome is essential for breeding superior cultivars. This economically important crop originates from hybridizations of highly polyploid Saccharum species. However, the large size (10 Gb), high degree of polyploidy, and aneuploidy of the sugarcane genome pose significant challenges to complete genome sequencing, assembly, and annotation.

A novel serous ovarian carcinoma model induced by DMBA: Results from OncoTherad® (MRB-CFI-1) immunotherapy preclinical testing.

Aims: The term ovarian carcinoma (OC) refers to a heterogeneous collection of five distinct diseases known as histotypes. While histotype-specific treatment is still a clinical challenge in OC, well-characterized models are required for testing new therapeutic strategies. We employed OncoTherad® (MRB-CFI-1), an interferon (IFN-γ)-stimulating nano-immunotherapy mediated by Toll-like receptors (TLR) 2/4, in association or not with Erythropoietin (EPO) in a chemically-induced ovarian cancer model.

Prognostic Factors in Head and Neck Cancer: A Retrospective Cohort Study of 3052 Patients in Brazil.

Objective: Evaluate the sociodemographic, clinical, and lifestyle characteristics at head and neck squamous cell carcinoma (HNSCC) diagnosis and their impact on overall survival (OS) across different anatomical sites.

Materials And Methods: A retrospective cohort study (2011-2021) at Instituto do Câncer do Estado de São Paulo, involving 3052 HNSCC patients. Survival analyses utilized the Kaplan-Meier method and Cox proportional hazard ratios with 95% confidence intervals, incorporating significant variables from univariate analysis.

3D-printed denture base resins: Glazing as an alternative to improve surface, mechanical, and microbiological properties.

Purpose: To evaluate the impact of glazing denture base resins (heat-polymerized and 3D-printed) on surface, mechanical, and microbiological properties.

Materials And Methods: Discs (10 × 3 mm) and bars (64 × 10 × 3.3 ± 0.

TiO nanotubes incorporated into a glaze-coating ceramic: surface roughness, color, and antibiofilm activity.

This study evaluated the surface roughness, color change, and antibacterial effect of a ceramic glaze enhanced with TiO nanotubes (n-TiO). n-TiO (0, 2, 2.5, and 5 wt%) was added to a ceramic glaze powder, applied to the surface of forty feldspathic ceramic specimens, and sintered.

MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration.

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015.

Unlocking the therapeutic potential of natural extract: A scoping review.

DC. (Geraniaceae) is a widely recognized medicinal plant whose natural extract exhibits therapeutic effects through a multi-target approach. Existing literature encompasses investigations of antimicrobial and cellular effects, including clinical trials.

Effect of high hydrostatic pressure on the physicochemical characteristics of low sodium mortadella containing a high level of mechanically deboned poultry chicken meat.

High hydrostatic pressure (HHP) is an emerging technology that can be applied to improve the functional properties of emulsified meat products. The aim of this study was to evaluate the effect of HHP (100 and 200 MPa) on low-sodium mortadella produced with high content of mechanically deboned poultry meat (MDPM). Seven treatments were produced: FC (2.

Evaluation of the Participation of Brazilian Women in Research in Oral Pathology and Oral Medicine.

Background: Despite recent advancements, women still encounter significant challenges in various fields, including dentistry. However, the increasing interest in female participation in science acknowledges its fundamental role in the advancement of knowledge. This study aims to assess indicators of women's involvement in Brazilian research in the areas of Oral Pathology and Oral Medicine.

Checklist of marine Bivalvia (Mollusca) from Brazil, with descriptive analyses of their bathymetric and geographical distribution.

After revising the literature and consulting the pertinent virtual databases, we here list all Brazilian marine bivalves currently considered as valid and include data on their geographical and bathymetrical distribution. The list contains 516 indigenous and nine introduced species. Among the former, 461 species are autobranchs and 64 are protobranchs.