398 results match your criteria: "State University "Julio de Mesquita Filho"- UNESP[Affiliation]"

Recurrence and resistance risk factors in low-risk gestational trophoblastic neoplasia.

Int J Gynecol Cancer

January 2025

New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

Article Synopsis
  • Gestational trophoblastic neoplasia (GTN) is a group of curable pregnancy-related tumors, but 25% of patients may experience treatment-resistant or recurring cases after chemotherapy.
  • The review highlights various factors affecting the prognosis of low-risk GTN, such as FIGO risk score, patient age, tumor characteristics, and hCG levels, emphasizing the need for personalized treatment approaches.
  • It also identifies independent risk factors for resistance and recurrence, noting that previous studies have limitations like small sample sizes and lack of comprehensive analysis, which could impact the understanding of these issues.
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Article Synopsis
  • The silverleaf whitefly is a major agricultural pest affecting crop yields globally, with limited research on insecticide effectiveness since the introduction of Mediterranean species in Brazil.
  • The study assessed the susceptibility of three Mediterranean whitefly populations to 11 different insecticides and analyzed their bacterial endosymbionts.
  • Results indicated significant variation in insecticide tolerance among populations, particularly with imidacloprid and thiamethoxam, emphasizing the need for regular toxicity testing and integrated pest management to maintain insecticide effectiveness.
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Bartonella spp. in bats from the Brazilian Amazon Forest.

Vet Res Commun

December 2024

Departament of Pathology, Reproduction and One Health, Vector-Borne Bioagents Laboratory (VBBL), Faculty of Agrarian and Veterinary Sciences Júlio de Mesquita Filho (UNESP), 14884-900, Jaboticabal Campus, Via Prof. Access Paulo Donato Castellane, s/n, Rural Zone, Jaboticabal, São Paulo, Brazil.

Despite the great diversity of bats (64 species) in the State of Acre, northwestern Brazil, there are no studies on occurrence and diversity of Bartonella spp. in bats in this region. The present study investigated the occurrence and molecular identity of Bartonella spp.

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Purpose: To determine the prewarming effect on body temperature in the perioperative period of patients undergoing conventional abdominal surgery and the level of thermal comfort.

Design: A randomized controlled clinical trial.

Methods: A Brazilian oncology hospital located in São Paulo.

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Humans have been using plants in the treatment of various diseases for millennia. Currently, even with allopathic medicines available, numerous populations globally still use plants for therapeutic purposes. Although plants constitute a safer alternative compared to synthetic agents, it is well established that medicinal plants might also exert adverse effects.

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Aedes mosquito-borne diseases remain a significant global health threat, necessitating effective control strategies. This study introduces monoterpenes-based nanohydrogels for potential use as repellents against , the primary dengue vector worldwide. We formulated hydrogels using cymene- and myrcene-based nanoemulsions with different polymers: chitosan, carboxymethylcellulose (CMC), and carbopol.

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Bisphosphonates are widely used for the treatment of postmenopausal osteoporosis; however, they cause several long-term side effects, necessitating the investigation of local ways to improve osseointegration in compromised bone tissue. The purpose of this study was to evaluate peri-implant bone repair using implants functionalized with zoledronic acid alone (OVX ZOL group, n = 11), zoledronic acid + teriparatide (OVX ZOL + TERI group, n = 11), and zoledronic acid + ruterpy (OVX ZOL + TERPY group, n = 11) compared to the control group (OVX CONV, n = 11). Analyses included computer-assisted microtomography, qualitative histologic analysis, and real-time PCR analysis.

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How anatomical impairments found on CT affect perfusion percentage assessed by SPECT/CT scan?

Ann Nucl Med

December 2024

Medical School, São Paulo State University Julio de Mesquita Filho, Av. Prof. Mário Rubens Guimarães Montenegro, S/N, UNESP Campus de Botucatu, Botucatu, SP, CEP: 18618687, Brazil.

Aim: CT images can identify structural and opacity alterations of the lungs while nuclear medicine's lung perfusion studies show the homogeneity (or lack of) of blood perfusion on the organ. Therefore, the use of SPECT/CT in lung perfusion scintigraphies can help physicians to assess anatomical and functional alterations of the lungs and to differentiate between acute and chronic disease.

Objective: To develop a computer-aided methodology to quantify the total global perfusion of the lungs via SPECT/CT images and to compare these results with parenchymal alterations obtained in CT images.

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Obesity is characterized by specific changes in the composition of the gut microbiota (GM). Exercise can contribute to the modulation of GM. This is the first case study to analyze the composition and metabolism of the GM of an obese runner in a single-stage mountain ultramarathon (MUM) with a mileage of 217 km.

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Maternal nutrition is one of the main environmental factors regulating gene expression during fetal development through epigenetic modifications. Some nutrients, such as the amino acid l-arginine, are added to maternal diets to modulate gene expression, improve the reproductive performance of females, and enhance conceptus development. This study investigated the hypothesis that supplementation of pregnant gilts with l-arginine regulates gene expression in conceptuses through epigenetic mechanisms.

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To evaluate the microstructural characterization, mechanical properties and antimicrobial activity of acrylic resins incorporated with different concentrations of reduced graphene oxide (rGO). Specimens were made of self-cured and heat-cured acrylic resins for the control group and concentrations of 0.5%, 1%, and 3%.

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Introduction: Squamous cell carcinoma (SCC) is a malignant neoplasm that accounts for approximately 15-25% and 70-80% of all feline cutaneous and oral tumors, respectively. Similar to that in humans, feline SCC can be highly invasive locally; however, its metastasis rate is low. Thus, effective local treatment may be curative for most patients, and includes surgery, electrochemotherapy (ECT), cryosurgery, or a combination of these.

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The aim of this study is to analyze the spatiotemporal risk of congenital syphilis (CS) in high-prevalence areas in the city of São Paulo, SP, Brazil, and to evaluate its relationship with socioeconomic, demographic, and environmental variables. An ecological study was conducted based on secondary CS data with spatiotemporal components collected from 310 areas between 2010 and 2016. The data were modeled in a Bayesian context using the integrated nested Laplace approximation (INLA) method.

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This study aimed to incorporate β-AgVO and rGO into self-curing (SC) and heat-curing (HC) acrylic resins and to evaluate their physicochemical, mechanical, and antimicrobial properties while correlating them with the characterized material structure. Acrylic resin samples were prepared at 0 % (control), 0.5 %, 1 %, and 3 % for both nanoparticles.

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Novel Tick-Borne Anaplasmataceae Genotypes in Tropical Birds from the Brazilian Pantanal Wetland.

Microorganisms

May 2024

Vector-Borne Bioagents Laboratory (VBBL), Department of Pathology, Reproduction and One Health, School of Agricultural and Veterinarian Sciences, Sao Paulo State University "Júlio de Mesquita Filho" (FCAV/UNESP), Jaboticabal 14884-900, Brazil.

Despite numerous reports of Anaplasmataceae agents in mammals worldwide, few studies have investigated their occurrence in birds. The present study aimed to investigate the occurrence and molecular identity of Anaplasmataceae agents in birds from the Pantanal wetland, Brazil. Blood samples were collected from 93 different species.

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Interleukin 17F Gene Polymorphism as a Potential Protective Factor in the Immunopathology of Ocular Toxoplasmosis.

Parasite Immunol

May 2024

Laboratory of Immunogenetics, Department of Molecular Biology, Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil.

Ocular toxoplasmosis (OT) is characterised by intraocular inflammation due to Toxoplasma gondii infection. Studies have found that interleukin 17 (IL-17) plays a central role in the pathology of OT. However, nucleotide variability in IL17 and interleukin 17 receptor (IL17R) genes has not been characterised in OT.

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Leishmaniases comprise a group of infectious parasitic diseases caused by various species of Leishmania and are considered a significant public health problem worldwide. Only a few medications, including miltefosine, amphotericin B, and meglumine antimonate, are used in current therapy. These medications are associated with severe side effects, low efficacy, high cost, and the need for hospital support.

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First molecular detection of Borrelia sp. in tapirs (Tapirus terrestris).

Vet Res Commun

August 2024

Vector-Borne Bioagents Laboratory (VBBL), Faculdade de Ciências Agrárias e Veterinárias (FCAV), Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) - Jaboticabal, São Paulo, Brazil.

Article Synopsis
  • Borrelia theileri is a tick-borne spirochete that causes health issues like fever and reduced food intake in cattle, and this study explores its presence in wild tapirs in South America.* -
  • Researchers collected blood samples from 99 tapirs across the Pantanal and Cerrado biomes, using a qPCR assay to detect B. theileri DNA, finding a low positive rate of 2% in tapirs from the Pantanal.* -
  • The study found sequences of B. theileri in tapirs closely related to previously detected sequences in cattle and various tick species from different regions, expanding knowledge on the potential hosts of this pathogen.*
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The fungus Thermothelomyces thermophilus is a thermotolerant microorganism that has been explored as a reservoir for enzymes (hydrolytic enzymes and oxidoreductases). The functional analysis of a recombinant cellobiose dehydrogenase (MtCDHB) from T. thermophilus demonstrated a thermophilic behavior, an optimal pH in alkaline conditions for inter-domain electron transfer, and catalytic activity on cellooligosaccharides with different degree of polymerization.

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What are the global patterns of microplastic ingestion by fish? A scientometric review.

Environ Pollut

June 2024

Graduate Program in Comparative Biology, State University of Maringá (UEM), Maringá, Brazil; Laboratory of Ichthyology, Ecology and Biomonitoring, State University of West Paraná (Unioeste), Rua Universitária, University Garden, 1619, Cascavel, PR, Brazil. Electronic address:

The billions of tons of plastic released into the environment mostly fragment into smaller particles that reach rivers and oceans, posing toxicity risks to aquatic organisms. As fish serve as excellent environmental indicator organisms, this study aims to comprehensively review and quantify published data regarding the abundance of microplastics (MPs) ingested by fish through scientometric analysis. Systematic analysis reveals that global aquatic ecosystems are contaminated by MPs, with the characteristics of these contaminants stemming from inadequate disposal management practices.

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MelastomaTRAITs 1.0: A database of functional traits in Melastomataceae, a large pantropical angiosperm family.

Ecology

June 2024

Centro de Síntese Ecológica e Conservação, Departamento de Ecologia, Genética e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

The recent availability of open-access repositories of functional traits has revolutionized trait-based approaches in ecology and evolution. Nevertheless, the underrepresentation of tropical regions and lineages remains a pervasive bias in plant functional trait databases, which constrains large-scale assessments of plant ecology, evolution, and biogeography. Here, we present MelastomaTRAITs 1.

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An augmentative biological control program using the egg parasitoid Ashmead (Hymenoptera: Platygastridae) is a promising tool for the management of the brown stink bug, (Fabricius) (Hemiptera: Pentatomidae) in soybeans. The are released as adults or pupae within lab-reared eggs. Because of the small size of the parasitoid and potentially limited dispersal ability, determining the optimal release pattern is critical for biological control of the target pest.

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Molecular evidence of Bartonella spp. in tropical wild birds from the Brazilian Pantanal, the largest wetland in South America.

Vet Res Commun

June 2024

Vector-Borne Bioagents Laboratory (VBBL), Departamento de Patologia, Reprodução E Saúde Única, Faculdade de Ciências Agrárias E Veterinárias, Universidade Estadual "Júlio de Mesquita Filho", (FCAV/UNESP), Campus de Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane, S/N, Zona Rural, São Paulo, Jaboticabal, CEP: 14884-900, Brazil.

Despite the worldwide occurrence of bartonellae in a broad range of mammal species, in which they usually cause a long-lasting erythrocytic bacteremia, few studies reported Bartonella spp. in avian hosts. The present work aimed to investigate the occurrence and molecular identity of Bartonella spp.

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Infectious and Parasitic Diseases (IPD) remain a challenge for medicine due to several interconnected reasons, such as antimicrobial resistance (AMR). American tegumentary leishmaniasis (ATL) is an overlooked IPD causing persistent skin ulcers that are challenging to heal, resulting in disfiguring scars. Moreover, it has the potential to extend from the skin to the mucous membranes of the nose, mouth, and throat in both humans and various animals.

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