Acid secretion-associated translocation of KCNJ15 in gastric parietal cells.

Potassium ions are required for gastric acid secretion. Several potassium channels have been implicated in providing K(+) at the apical membrane of parietal cells. In examining the mRNA expression levels between gastric mucosa and liver tissue, KCNJ15 stood out as the most highly specific K(+) channel in the gastric mucosa.

Light-dark oscillations in the lung transcriptome: implications for lung homeostasis, repair, metabolism, disease, and drug action.

Diurnal-nocturnal, or circadian-like, rhythms are 24-h variations in biological processes, evolved for the efficient functioning of living organisms. Such oscillations and their regulation in many peripheral tissues are still unclear. In this study, we used Affymetrix gene chips in a rich time-series experiment involving 54 animals killed at 18 time points within the 24-h cycle to examine light-dark cycle patterns of gene expression in rat lungs.

Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle.

The existence and maintenance of biological rhythms linked to the 24-h light-dark cycle are essential to the health and functioning of an organism. Although much is known concerning central clock mechanisms, much less is known about control in peripheral tissues. In this study, circadian regulation of gene expression was examined in rat skeletal muscle.

Nitric oxide-dependent stimulation of endothelial cell proliferation by sustained high flow.

Little is understood about endothelial cell (EC) responses to high flow, which mediate adaptive outward remodeling as well as cerebral aneurysm development. Opposite EC behaviors have been reported in vivo including cell loss during aneurysm initiation and cell proliferation during adaptive outward remodeling. This study aims at elucidating the EC growth response to elevated wall shear stress (WSS) and determining if nitric oxide (NO) is involved.

Measurement of flow modification in phantom aneurysm model: comparison of coils and a longitudinally and axially asymmetric stent--initial findings.

Dye-dilution imaging sequences were performed and time-density curves were constructed in elastomer vessel aneurysm models to demonstrate the effectiveness of coils and an asymmetric stent in disrupting standard vortex flow. Compared with the use of coils, the use of stents led to marked flow modification, as seen with imaging sequences, and substantially slower inflow, as indicated by time-density curves, owing to the low-porosity region of the stent that covers the aneurysm orifice. These flow examination results indicate that potentially favorable flow modification features can be created by using the described asymmetric stent design, the use of which may lead to alternative methods of image-guided endovascular cerebral aneurysm therapy.

Combination median filter.

A detail- and structure-preserving smoothing filter is introduced. It is called the combination median filter as it uses directional median, multilevel median, and median filters to smooth different regions of the image. The decision about the region is made by robust Dixon's r-test which is well known in statistics for outlier detection.

Reconstruction in diffraction imaging.

The problem of reconstruction in imaging systems that are modeled using the Helmholtz wave equation (diffraction imaging) is addressed. A spectral analysis of the available diffraction data is presented to help develop algorithms and constraints on a diffraction imaging system's parameters for accurate reconstruction of the desired image. Means of reducing the execution time of these algorithms and their relationship to currently available filtered backpropagation and unified Fourier reconstruction methods are also discussed.