State Research Institute Centre of Inno... Publications

Clinical Trial Review Systematic Review Meta-Analysis Books and Documents Randomized Controlled Trial

1 results match your criteria: "State Research Institute Centre of Innovative Vilnius[Affiliation]"

Page 1 of 1

GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats.

Mol Cell Endocrinol

December 2013

Department of Clinical Science, SUS, Division of Islet Cell Physiology, University of Lund, Sweden; Department of Stem Cell Biology, State Research Institute Centre of Innovative Vilnius, Lithuania.

Sandra Meidute Abaraviciene Sarheed J Muhammed Stefan Amisten Ingmar Lundquist Albert Salehi

The role of islet GPR40 protein in the pathogenesis of diabetes is unclear. We explored the influence of GPR40 protein levels on hormone secretion in islets from two rat models of spontaneous type 2 diabetes displaying either hyperlipidaemia or hyperglycaemia. GPR40 expression was analysed by confocal microscopy, Western blot and qPCR in islets from preobese Zucker (fa/fa) rats, diabetic Goto-Kakizaki (GK) rats, and controls.

View Article and Find Full Text PDF

Similar Publications

Geographic Location

Publish Date

Article Type

GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats.