Effects of continuous and intermittent aerobic exercise upon mRNA expression of metabolic genes in human skeletal muscle.

Aim: It is known that intermittent aerobic exercise training program is more efficient for the improvement of aerobic performance than continuous one but molecular mechanisms of such effects are purely understood. The aim of the present study was to compare gene expression of mitochondrial biogenesis regulators (peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), mitochondrial transcription factors A (TFAM) and B2 (TFB2M) and genes involved in exercise-induced catabolic events (forkhead box O1 (FOXO1) and Atrogin-1) in human skeletal muscle after single continuous (CE) and intermittent (IE) aerobic exercise sessions, equalized thoroughly in duration and mean power output.

Methods: Twelve physically active males performed CE (workload at lactate threshold [LT], 50 min) or IE ([3 min 81% LT+2 min 125% LT]x10).

Effects of support stimulation on human soleus fiber characteristics during exposure to "dry" immersion.

In this study the model of 7-day dry immersion (DI) was used. 17 male volunteers (23-29 years old) were divided in 2 groups: (i) 7-day DI without support (DI, n=9), (ii) 7-day DI using support stimulation (DIS, n=8). Support stimulator device exerted pressure of 0.

[Effect of space flight factors on health of cosmonauts in the near and late term after space flights].

Cytogenetical studies of cosmonauts' peripheral blood lymphocytes after space flights on MIR orbital station showed a statistically significant increase in the yields of radiation-induced chromosomal aberrations. However, similar studies with in vitro irradiation of biological objects with accelerated charged particles are of great importance for elucidation of the nature of cytogenetical damage induced in vivo. It is also important to investigate the structure of cosmonatus' diseases over their life, in particular, lens opacities and oncological diseases.