[The CD45-positive thrombocytes and neutrophils/lymphocytes level ratio in evaluation of risk of development of re-stenosis шт patients with chronic ischemic heart disease and diabetes mellitus type II.].

The purpose of study is to investigate significance of detection of number of CD45-positive thrombocytes and ratio neutrophils/lymphocytes in evaluation of risk of development of re-stenosis after implantation of drug-eluting stents in patients with chronic ischemic heart disease and diabetes mellitus type II. The examination was applied to 126 patients with chronic forms of ischemic heart disease who passed through repeat coronary angiography during first year after implantation of drug-eluting stents. The patients were separated on two groups depending on availability of diabetes mellitus type II.

[The physiological and biochemical methods of increasing of energy diffusion in vivo as a reaction of compensation under obesity.].

The article presents the analysis concerning main directions of physiological increasing of expenditure of energy in organism that probably can be used for prevention of obesity. First of all, it's increasing of physical load and activation of heat production at cold adaptation. In both cases the leading role belongs to skeletal muscles and consists in both implementation of biological function of locomotion and regulation of metabolism.

Effects of deafferentation on the size and myosin phenotype of muscle fibers on stretching of the rat soleus muscle in conditions of gravitational unloading.

The aim of the present work was to assess the contributions of the reflex and local components to preventing decreases in the size and changes in the ratio of fibers containing the slow and fast isoforms of myosin heavy chains during chronic stretching of a postural muscle in rats in conditions of gravitational unloading. A unilateral surgical deafferentation method was used. The results demonstrated that deafferentation of the hindlimb had no effect on preventing reductions in muscle fiber size in conditions of chronic muscle stretching in conditions of gravitational unloading.

Characteristic of changes in the structure and metabolism of the vastus lateralis muscles in monkeys after space flight.

Monkeys subjected to space flight were found to have significant decreases in the sizes of slow and rapid fibers in the vastus lateralis muscle, due not only to weightlessness but also, to some extent, to restriction of movement activity within the capsule. The quantity of total protein in muscle fibers did not decrease. The respiratory peak in the pool of vastus lateralis muscle fibers decreased after space flight, as did the activity of oxidative enzymes (particularly in rapid fibers of the vastus lateralis muscle).

[The Parity technique as an example of an analytical approach to designing computerized psychological tests].

The new computer technique "Paritet" for studying the function of attention and visual perception was developed by the author in 1995. This technique has been tested in the combined experiment "ECOPSI-95". The study results reveal the differences in the visual perception of symmetric and nonsymmetric images, combined and separate elements of the image.

[Combined effect of hypokinesia of various duration and gamma-radiation on central nervous system activity in rats].

There studied the effects of a combined effect of hypokinesia (HK) of various duration (7 and 30 days, corresponding to the stages of anxiety and resistance of general adaptation syndrome) and gamma-radiation dose of 3 Gy on the formation of differentiated motor-drinking conditioned reflex (CR) in the rats. It is demonstrated that the applied exposures lead to the various disorders of the higher nervous activity of the test animals: after 7-day hypokinesia in the behaviour there prevail the fear and emotional-vegetative components whereas following 30-day hypokinetic exposure there occurs some stimulation of the orientation-exploratory behaviour with concurrent enhancement of the inertness of nervous processes and the tendency to formation of stringent behavioural stereotypes slowing-down the conditioned reflex formation. A modifying effect of radiation counts only after 30-day hypokinesia and consists in the development of extra-limited inhibition (reaction of acquired helplessness) in the part of animals.

[Changes in bone tissue of women under condition of 120 days antiorthostatic hypokinesia].

The state of bone tissue has been studied in 8 women subjected to a 120-day HDT. Four test subjects (Group A) performed physical exercises during the experiment. Mineral content (MC) in bone tissue and mineral density of the bones (MD) were determined with the help of dichromatic x-ray bone densitometer HOLOGIC QDR--100/W.

[Use of bicycle ergometry test for studying metabolism in women during long-term hypokinesia].

Studies performed under conditions of a 120-day HDT in the female human subjects demonstrated that out of 20 biochemical parameters of the blood characterizing the carbohydrate and lipid exchange only 14 indices changed significantly during hypokinesia. As this takes place, the maximum number of changes was revealed with the help of the graded physical load test (GPL-test) and only in case of 9 indices the alterations were found at rest. Physical loads which have been used during HDT as the preventive measures had no effect only on insignificant part of metabolic shifts such as hypokinesia-associated increase of an activity of blood lactate dehydrogenase and relative content of phosphatidylcholine as well as an increased blood content of phosphates and decreased relative portion of phospholipids which also revealed with the aid of GPL-test.

[Effect of 135 days human stay in chamber on the composition of electrophoretic fraction and levels of some individual plasma proteins].

The investigation was performed with three test-subjects who were locked in a chamber with simulated spaceflight environment for 135 days. Samples of venous plasma were collected to determine concentrations of total protein, total cholesterol (TCh), cholesterol of high density lipoproteins (HDLP), alpha 1-inhibitor of proteolysis (alpha 1-Pl), alpha 2-microglobulin (alpha 2 M), and haptoglobin (Hp). Concentrations of cholesterol of low density lipoproteins (Ch LDLP) and HDLP-LDLP ratio were calculated.

[Biological techniques in space].

The review is dedicated to the biotechnological studies in space. The main directions of studies in the space biotechnology are the developments of life support systems, crystallogenesis of biological macromolecules, separation of proteins and cells with the help of electrophoresis as well as the studies of cellular, subcellular and molecular processes induced by the spaceflight factors effect. The experience gained in the cultivation of unicellular organisms, the selection of perspective species and strains of microorganisms, the use of them in the ecological life-support system under development is considered in detail.

[Metabolic and structural aspects of cellular homeostasis in long-term isolation].

Metabolism and structural/functional status of membrane of blood cells (erythrocytes, lymphocytes) were investigated in human subjects during simulation of MIR environment and operations, and postflight activities. Homeostasis of the blood count cells was assessed by the parameters of intercellular metabolism. Histochemical technique was used to evaluate the activity of mitochondrial enzymes succinate dehydrogenase and alpha-glycerphosphate dehydrogenase in lymphocytes.

[Evaluation of alternations in mental performance due to the effect of extended isolation].

Dynamics of mental performance, critical periods of adaptation, and cognitive processes were studies in conjunction with extended experimental isolation. Training to simple motor skills was found to be less impeded by prolonged isolation as opposed to operations requiring active involvement of higher psychic functions (memory, concentration, thinking). Experiments HUBES and ECOPSY strengthened the hypothesis concerning possible advent of critical periods in prolonged isolation impacting mental performance.

[Functional test with potassium chloride following long-term space mission].

To look into the potassiuretic function of kidneys in 11 cosmonauts on the second day post recovery after six-month MIR missions, functional testing with potassium chloride was performed. The following standard procedure was used before and after the missions: during morning hours fasting test-subjects consumed a 10% solution of potassium chloride in the amount of 0.55 ml/kg or 0.