Assessment of socio-demographic characteristics and social status of patients with negative symptoms in schizophrenia at different stages of the disease.

Objective: Aim: To determine the features of socio-demographic characteristics of patients with negative symptoms of schizophrenia.

Patients And Methods: Materials and Methods: 252 patients with negative symptoms of schizophrenia took part in the study: 83 patients with the first episode of schizophrenia, 88 patients with schizophrenia in a state of exacerbation, and 81 patients with schizophrenia in a state of remission. During the research, a comprehensive approach was used, which consisted in the use of clinical-psychopathological, clinical-anamnestic and statistical research methods.

THE RELATIONSHIP BETWEEN THE DURATION OF REMISSIONS AFTER THE ONSET, THE SEVERITY OF THE RELAPSES AGAINST THE BACKGROUND OF DIFFERENT DURATION OF THE RELAPSING STAGE AND THE NATURE OF THE PROGNOSIS IN SECONDARY-PROGRESSIVE MULTIPLE SCLEROSIS.

Work objective - to study the relationship between the duration of remission after the onset, the severity of relapses against the background of different duration of the relapsing stage (RS) and the nature of the prognosis in the secondary progressive multiple sclerosis (SPMS) using clinical and mathematical analysis. Patients with different prognosis for SPMS; neurological examination using The Expanded Disability Status Scale (EDSS); a survey method. Mathematical methods: 'contingency tables 2x2' (determining the significance of the connection between a pair of two indicators - different duration of remission after the onset and RS in four groups of patients), Yule's Coefficient of Association (determining the magnitude of differences between the group and the studied indicator), a permutation test (defining clinical indicators on RS, which significantly differed in mild and severe relapses).

MINE-BLAST TRAUMA AS A FACTOR IN THE EARLY DEVELOPMENT OF VASCULAR DISEASES OF THE BRAIN.

Objective: The aim of this study is to investigate the state of bulbar conjunctival vessels, rheological properties of blood, catecholamines (adrenaline, norepinephrine), lipid metabolism, alkaline proteins of blood serum in patients with consequences of mild combat traumatic brain injury.

Patients And Methods: Materials and methods: 76 individuals aged 28 to 41 years were examined. The duration of the injury lasted from 2 to 4 years.

The cumulative effect of the combined action of miR-101 and curcumin in a liposome on a model of Alzheimer's disease in mononuclear cells.

The leading pathological mechanisms of Alzheimer's disease (AD) are amyloidosis and chronic inflammation. The study of new therapeutic drugs of the corresponding action, in particular miRNAs and curcominoids, as well as methods for their packaging, is topical. The aim of the work was to study the effect of miR-101 + curcumin in a single liposome in a cellular AD model.

Clinical decision-making style preferences of European psychiatrists: Results from the Ambassadors survey in 38 countries.

Background: While shared clinical decision-making (SDM) is the preferred approach to decision-making in mental health care, its implementation in everyday clinical practice is still insufficient. The European Psychiatric Association undertook a study aiming to gather data on the clinical decision-making style preferences of psychiatrists working in Europe.

Methods: We conducted a cross-sectional online survey involving a sample of 751 psychiatrists and psychiatry specialist trainees from 38 European countries in 2021, using the Clinical Decision-Making Style - Staff questionnaire and a set of questions regarding clinicians' expertise, training, and practice.

FEATURES OF COPING STRATEGIES IN THE POPULATION DURING QUARANTINE IN CONDITIONS OF EPIDEMIC DANGER.

Objective: The aim: The purpose of this study was to examine the most common coping strategies in the population in quarantine settings.

Patients And Methods: Materials and methods: The study used the following set of methods: a general questionnaire aimed at studying socio-demographic data, living conditions during quarantine, lifestyle during quarantine, the presence of chronic diseases and psychodiagnostic methods: assessment of distress R.Kessler, assessment of the presence of manifestations of anxiety-depressive response GAD-7, depression self-assessment scale PHQ-9, stress-overcoming behavior strategies (E.

[NEUROPSYCHOLOGICAL ANALYSIS OF DISORDERS OF HIGHER MENTAL FUNCTIONS IN PATIENTS WITH DIFFERENT TYPES OF MULTIPLE SCLEROSIS].

Patients with RR (n=45) and SP (n=24) types of multiple sclerosis (MS) were analyzed using original Luria neuropsychological battery. On the basis of the results obtained, the general characteristics of neuropsychological syndromes were determined: asthenic manifestations; certain violations of the auditory-speech memory; decreased visual memory; disorders of interhemispheric somatosensory transfer; violations of the simultaneous factor of the mental activity organization. It is shown that the progressive type of MS is characterized by a significantly greater degree of severity of the above disorders, as well as their certain qualitative features: a wider range of mnestic disorders; the presence of disturbances in the interhemispheric transfer of motor information; the presence of violations of the assessment of rhythmic sequences by ear; the presence of visual-constructive activity disorders.

PSYCHOLOGICAL FACTORS AND CONSEQUENCES OF PSYCHOSOCIAL STRESS DURING THE PANDEMIC.

Objective: The aim: Study of psychological factors and consequences of psychosocial stress which is formed during the COVID-19 pandemic.

Patients And Methods: Materials and methods: In the research, we used methods: developed a common, assessment of psychosocial stress L. Reeder scale, assessment of distress R.

[CLINICAL-MATHEMATICAL ANALYSIS OF INTERRELATIONS BETWEEN A CHARACTER OF THE PROGNOSIS AND PECULIARITIES OF ONSETS IN DIFFERENT TYPES OF MULTIPLE SCLEROSIS COURSE].

Aim of the study- to assess the prognostic value of indicators characterizing the course of the of multiple sclerosis onset (MS) using clinical-mathematical analysis. Patients with MS with different prognosis: good and uncertain for the relapsing-remitting type; uncertain and poor for progressive types of clinical course. A neurological examination using The Expanded Disability Status Scale (EDSS); a questionnaire method; determination of the Yule's coefficient of association (coefficient of colligation), the separating hyperplane method and the correlation analysis.

CLINICAL, GENEALOGICAL AND PATHOPSYCHOLOGICAL RISK MARKERS OF RECURRENT DEPRESSION.

The goal was to determine clinical and genealogical and pathophysiological markers of the risk recurrent depression development risk. Clinical and psychopathological, genealogical, psychometric (Montgomery-Asberg Depression Rating Scale - MADRS), "Psychological Autobiography" method (Burlachuk L.F.

THE TESTOSTERONE-CORTISOL MODEL AS A WAY TO UNDERSTAND THE MECHANISM OF ALCOHOL DEPENDENCE WHICH STARTED IN PUBERTY.

Objective: The aim: Is to analyze the role of testosterone and cortisol in the mechanism of alcohol use disorders formation for further development of early diagnosis and prevention methods.

Patients And Methods: Materials and methods: 155 adolescents at the preclinical stages of alcohol use disorders formation and 87 young patients with diagnosed alcohol dependence were studied by enzyme-linked immunoassay techniques.

Results: Results: The analysis of the obtained materials shows that the onset of search behaviors on alcohol consumption, frequency and alcohol abuse in adolescents occur with the participation of age-related processes of somatic puberty and the related syndromes of hormonal tension.

[ARCHITECTONICS OF THE NIGHT SLEEP BASED ON ITS POLYSOMNOGRAPHIC CHARACTERISTICS IN PATIENTS WITH MULTIPLE SCLEROSIS].

Aim of our study is to establish polysomnographic characteristics of nocturnal sleep in various forms of multiple sclerosis. Fifty eight patients with different clinical course of multiple sclerosis (MS) were included into the study. Disturbances of sleep architectonics were identified: representation of deep stages of NREM sleep, as well as REM sleep were reduced.

[PSYCHO-EDUCATIONAL PROGRAM IN PREVENTION OF MENTAL HEALTH OF INTERNALLY DISPLACED PERSONS].

The goal is to develop and evaluate the effectiveness of a psychoeducational program (PP) aimed at timely detection, prevention of the formation and prevention of chronicity of mental disorders in internally displaced persons (IDPs). 414 IDPs took part in the research. A complex of clinical-psychopathological, psychometric, psychodiagnostic and statistical methods were used.

Subclinical emotional distress predicts 6-month clinical outcomes after ST-segment elevation myocardial infarction.

To investigate associations between subclinical distress and 6-month clinical outcomes after ST-segment elevation myocardial infarction (STEMI). The case-control study involved 144 STEMI patients (72 STEMI having subclinical emotional disturbances were included to the case group and 72 STEMI individuals matched with age, sex and cardiovascular risk factors were enrolled to the control group). The primary end point was the combination of 6-month events including CV death, recurrent angina, newly diagnosed heart failure and re-hospitalization.

Addictive behavior among young people in Ukraine: a pilot study.

The AUDIT-like tests system was created for complex assessment and evaluation of the addictive status of adolescents in a Ukrainian population. The AUDIT-like tests system has been created from the Alcohol Use Disorders Identification Test (AUDIT) developed by the World Health Organization. The AUDIT-like tests were minimally modified from the original AUDIT.