2,188 results match your criteria: "Star Women & Children Hospital[Affiliation]"

Article Synopsis
  • Understanding the relationship between breast cancer and its microenvironment is crucial for improving treatment and outcomes.
  • Researchers identified two distinct transcriptomic subtypes and five immune infiltration patterns in a study of 21 estrogen receptor-positive (ER+) and HER2-negative invasive lobular carcinomas (ILCs).
  • A notable finding was that a proliferative subtype had higher levels of suppressive immune cells, while a specific gene signature linked to lower proliferation and more pro-inflammatory tumor-associated macrophages indicated better survival rates in ER+ breast cancer patients.
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Effect of Finerenone on the KCCQ in Patients With HFmrEF/HFpEF: A Prespecified Analysis of FINEARTS-HF.

J Am Coll Cardiol

January 2025

British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom. Electronic address:

Article Synopsis
  • * The FINEARTS-HF trial compared the effectiveness of finerenone, a nonsteroidal mineralocorticoid receptor antagonist, against a placebo, measuring primary outcomes like cardiovascular death and HF worsening events.
  • * Results showed that lower KCCQ Total Symptom Scores (TSS) indicated a higher risk of adverse events, but finerenone significantly reduced event risks across all KCCQ TSS tertiles, suggesting it may improve outcomes for patients with varying levels of symptom severity.
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Background: Phenotypic age (PhenoAge), a widely used marker of biological aging, has been shown to be a robust predictor of all-cause mortality and morbidity in different populations. Existing studies on biological aging have primarily focused on individual domains, resulting in a lack of a comprehensive understanding of the multi-systemic dysregulation that occurs in aging.

Methods: PhenoAge was evaluated based on a linear combination of chronological age (CA) and 9 clinical biomarkers in 952 multi-ethnic Asian women of reproductive age.

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Protocol for detection of tRNA-derived fragments in cells, tissues, and plasma.

STAR Protoc

December 2024

Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China. Electronic address:

tRNA-derived fragments (tRFs) are frequently dysregulated in cancers, and approaches for the detection of tRFs within biological samples are vital for their expression analysis and functional exploration. Here, we present a protocol for detecting tRFs using a modified TaqMan quantitative real-time PCR (qRT-PCR)-based technique, Dumbbell-PCR (Db-PCR). We describe steps for primer and adapter design, adapter-RNA ligation, and RNA detection.

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Discoveries in nanotechnologies are placing a great deal of attention on greener strategies that use harmless substances and moderated reactions to promote healthy development. This work used a straightforward, innovative, and cost-effective sustainable approach to produce bio-augmented TiO nanometer-sized particles (NMSP) by applying a water-based extract of the star fruit as a stabilization and reduction agent. A variety of techniques, comprising UV-Vis, XRD, FT-IR, FE-SEM with EDAX, and TEM, have been employed to investigate the formed TiO NMSP.

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Fluorescence imaging in the second near-infrared window (NIR-II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR-II probes are limited by either being "always on" or responding to one stimulus, leading to low signal-to-noise ratios and potential false positives. We introduced a dual-lock-controlled probe, HN-PBA, activated by both HO and tumor acidic environment.

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Influence of consuming coffee and other beverages in adolescence on risk of type 2 diabetes in adulthood.

Eur J Epidemiol

October 2024

Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, 665 Huntington Avenue, Building 2, Room 349, 02115, Boston, MA, U.S.A..

Article Synopsis
  • This study investigates the impact of beverage consumption during adolescence on the risk of developing type 2 diabetes (T2DM) in adulthood, using a cohort of 41,317 women from the Nurses' Health Study II.
  • It found that higher intake of coffee and orange juice in adolescence was linked to a lower risk of T2DM, while regular soda and iced tea consumption was associated with a higher risk.
  • Changes in beverage habits from adolescence to adulthood also influenced T2DM risk, with increased coffee intake reducing risk and increased regular soda consumption elevating it.
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Background: Finerenone has kidney-protective effects in patients with chronic kidney disease with type 2 diabetes, but effects on kidney outcomes in patients with heart failure with and without diabetes and/or chronic kidney disease are not known.

Objectives: The purpose of this study was to examine the effects of finerenone on kidney outcomes in FINEARTS-HF (Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients With Heart Failure), a randomized trial of finerenone vs placebo among patients with heart failure with mildly reduced or preserved ejection fraction.

Methods: We explored the effects of finerenone on the secondary outcome of a sustained ≥50% estimated glomerular filtration rate (eGFR) decline or kidney failure (sustained eGFR decline <15 mL/min/1.

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Blood transcriptomic analyses do not support SARS-CoV-2 persistence in patients with post-COVID-19 condition with chronic fatigue syndrome.

Lancet Microbe

October 2024

Mike Petryk School of Dentistry, Division of Foundational Sciences University of Alberta, Edmonton, AB T6G 2E1, Canada; Li Ka Shing Institute of Virology University of Alberta, Edmonton, AB T6G 2E1, Canada; Women and Children Health Research Institute University of Alberta, Edmonton, AB T6G 2E1, Canada; Cancer Research Institute of Northern Alberta University of Alberta, Edmonton, AB T6G 2E1, Canada; Glycomics Institute of Alberta, Faculty of Medicine and Dentistry University of Alberta, Edmonton, AB T6G 2E1, Canada. Electronic address:

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Visceral adipose tissue (VAT) abnormalities are directly associated with obesity-associated disorders. The underlying mechanisms that confer increased pathological risk to VAT in obesity have not been fully described. A case-control study was conducted that included 10 women with obesity (36.

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Osteosarcoma (OS) is the most prevalent bone neoplasm of mesenchymal origin, accounting for 20% of all bone tumors worldwide. It mainly affects the marrow of long bones, and its diagnosis is more common among adolescents and the geriatric population. Histologically, it is characterized by high cellular variability, abundant osteoid and fibrotic material.

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Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis.

Sci Immunol

November 2024

Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.

In adults, liver-resident macrophages, or Kupffer cells (KCs), reside in the sinusoids and sterilize circulating blood by capturing rapidly flowing microbes. We developed quantitative intravital imaging of 1-day-old mice combined with transcriptomics, genetic manipulation, and in vivo infection assays to interrogate increased susceptibility of newborns to bloodstream infections. Whereas 1-day-old KCs were better at catching in vitro, we uncovered a critical 1-week window postpartum when KCs have limited access to blood and must translocate from liver parenchyma into the sinusoids.

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Reduced generation of multiple motile cilia (RGMC) represents a rare variant of Primary Ciliary Dyskinesia (PCD), associated with mutations. We report a novel compound mutation in the gene in an adult Chinese Singaporean exhibiting chronic productive cough since childhood and recurrent sino-pulmonary infections. Low nasal nitric oxide and bronchiectasis suggests PCD.

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Postpartum Screening for Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus: A Cost-Effectiveness Analysis in Singapore.

Value Health Reg Issues

October 2024

Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore; Department of Paediatrics, National University of Singapore, Singapore, Singapore.

Objectives: In Singapore, diabetes imposes a huge population health and economic burden. Despite that, there is paucity of evidence on the health economics of screening programs for type 2 diabetes, especially in the context of screening after gestational diabetes (GDM). The objective of this study is to assess cost-effectiveness of universal lifelong screening for type 2 diabetes after GDM, which is supported by current guidelines, compared with elective screening where 54% of mothers with GDM undertake one-off screening.

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The fabrication of the green strategy of metallic oxide creation provides considerable profits via a minimum of effort, making it an acceptable substitute to the most laborious and challenging conventional processes. The suggested approach involved the creation of titanium dioxide (TiO) nanoparticles through Orthosiphon stamineus extracts of leaves. The synthesized nanoparticles (NPs) were then characterized using XRD, FT-IR, FE-SEM with EDX, and UV-visible spectroscopy.

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Dr Yee Hwee Lim currently leads a team of more than 25 researchers in the Chemical Biotechnology and Biocatalysis division at the A*STAR Institute of Sustainability for Chemicals, Energy and Environment (A*STAR ISCE) to develop integrative technologies at the interface between chemistry, biology, informatics, and engineering for sustainable chemical manufacturing.

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Sleep tracking by consumers is becoming increasingly prevalent; yet, few studies have evaluated the accuracy of such devices. We sought to evaluate the accuracy of three devices (Oura Ring Gen3, Fitbit Sense 2, and Apple Watch Series 8) compared to the gold standard sleep assessment (polysomnography (PSG)). Thirty-five participants (aged 20-50 years) without a sleep disorder were enrolled in a single-night inpatient study, during which they wore the Oura Ring, Fitbit, and Apple Watch, and were monitored with PSG.

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Objective: This study aimed to assess whether exposure to hyperglycemia influences prescription medicine purchases in the offspring of women with type 1 diabetes (exposed offspring).

Patients/materials And Methods: We identified all singleton exposed offspring born in the hospital district of Helsinki and Uusimaa, Finland, between 1988 and 2011 from the Finnish Medical Birth Register, maintained by the Finnish Institute for Health and Welfare. For each exposed offspring, we obtained five age- and province-matched offspring of women without diabetes (reference offspring), from the Finnish Medical Birth Register.

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The focus of current advances in nanotechnology has shifted significantly towards environmentally conscious methods that use harmless ingredients and moderated reaction circumstances to promote equitable development. Zinc oxide nanoparticles (NPs) currently grabbed attention of multiple medical fields owing to their unique ability to safeguard against cellular damage and alleviate serious human diseases via processes related to metabolism. This work focused on the generation of ZnO NPs using the peel of Cucumis melo fruit.

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Lighting up arginine metabolism reveals its functional diversity in physiology and pathology.

Cell Metab

January 2025

Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Research Unit of New Techniques for Live-cell Metabolic Imaging, Chinese Academy of Medical Sciences, Beijing 100730, China. Electronic address:

Article Synopsis
  • * The researchers developed high-performance fluorescent biosensors called sensitive to arginine (STAR) that allow for real-time monitoring of arginine levels in cells, mice, and clinical samples.
  • * Using STAR, they discovered the influence of different amino acids on arginine levels and found that serum arginine levels tend to rise with age, which could help in assessing the progression of conditions like vitiligo.
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Wearable Sensors, Data Processing, and Artificial Intelligence in Pregnancy Monitoring: A Review.

Sensors (Basel)

October 2024

Singapore Institute of Manufacturing Technology, Agency for Science, Technology and Research (A*STAR), 5 Cleantech Loop, Singapore 636732, Singapore.

Article Synopsis
  • Pregnancy monitoring is crucial for the health of mothers and fetuses, with WHO reporting 287,000 maternal deaths in 2020, sparking a need for more accessible options than traditional hospital visits.
  • Advances in wearable sensors and AI are making home-based, non-invasive health monitoring for pregnant women more feasible and convenient.
  • The review highlights the role of wearable sensors in tracking physiological signals and how AI can enhance early detection and diagnosis, while also addressing ongoing challenges like accuracy and data privacy.
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Changes in Breast Cancer Screening Prevalence in the United States during the COVID-19 Pandemic, 2018 to 2022.

Cancer Epidemiol Biomarkers Prev

January 2025

Surveillance & Health Equity Science, American Cancer Society, Atlanta, Georgia.

Article Synopsis
  • - Annual mammography screening in the U.S. declined for the first time since 2018, with up-to-date screening dropping from 78.7% in 2018 to 76.6% in 2022, indicating 747,791 fewer women met the screening recommendations.
  • - Although there was a slight increase in past-year breast cancer screening (from 57.9% to 59.6% between 2020 and 2022), significant disparities were noted, particularly among American Indian/Alaska Native women and those with lower educational levels.
  • - The study highlights the ongoing impact of the COVID-19 pandemic on women's health screenings and calls for further research to understand how these trends affect breast cancer diagnosis
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Lung cancer incidence rates in young women and men by state in the United States.

Int J Cancer

February 2025

Surveillance and Health Equity Science, American Cancer Society, Atlanta, Georgia, USA.

Previous studies reported higher lung cancer incidence in women than men among persons aged 35-54 years in the United States, a reversal of historically higher rates in men. We examined whether this pattern varies by state. Based on lung cancer incidence (2015-2019) data among adults aged 35-54 years from Cancer in North America database and historical cigarette smoking prevalence data (2004-2005) among adults 20-39 years from the Behavioral Risk Factor Surveillance System, incidence rates in women were equal to or higher than rates in their male counterparts in 40 of 51 states, with statistically significant differences in 20 states (two-sided, p < .

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Oocyte-derived growth differentiation factor 9 suppresses the expression of CYP17A1 and androgen production in human theca cells.

F S Sci

February 2024

Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China; Guangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China. Electronic address:

Article Synopsis
  • The study aimed to explore how growth differentiation factor 9 (GDF9) affects androgen production in theca cells, which are related to ovarian function.
  • Researchers treated cultured human theca cells with GDF9, an ALK5 inhibitor, and a SMAD4 agonist to observe changes in gene expression related to androgen synthesis and related signaling pathways.
  • The results showed that GDF9 reduced the expression of key genes involved in androgen production and activated specific signaling pathways, indicating its role in suppressing androgen production in these cells.
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