657 results match your criteria: "Staphylococcal Scalded Skin Syndrome"
17q12 microdeletion syndrome.
BMJ Case Rep
November 2024
Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India
Article Synopsis
- An infant girl developed widespread blisters and skin peeling, along with fever and cough, showing signs of growth and developmental delays.
- Imaging revealed kidney abnormalities, and genetic testing indicated a deletion on chromosome 17 affecting the HNF1B gene.
- Despite the potential diagnosis of Staphylococcal Scalded Skin Syndrome (SSSS), the child was effectively treated with antibiotics, highlighting an unusual case of 17q12 deletion syndrome with early kidney disease and pre-diabetes.
Understanding host's response to staphylococcal scalded skin syndrome.
Acta Paediatr
October 2024
Department of Paediatrics, School of Medicine, University of Crete, Heraklion, Greece.
Aim: The aim of this review was to summarise the current knowledge on host-related factors that contribute to the development and severity of staphylococcal scalded skin syndrome (SSSS) in children.
Methods: A comprehensive assessment and analysis of the existing literature on SSSS clinical features, pathogenesis and susceptibility factors.
Results: SSSS is a blistering skin disease caused by circulating exfoliative toxins (ETs) of Staphylococcus aureus (S.
Crystal structure of exfoliative toxin D from Staphylococcus aureus.
Biochem Biophys Res Commun
November 2024
Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Fuchu, 183-8509, Japan. Electronic address:
Article Synopsis
- * This study provides a detailed crystal structure of ETD at 1.75 Å resolution, revealing a composition of two β-barrels and two α-helices, similar to other ET structures.
- * A model suggests that a segment of human desmoglein-1 (IEGP) interacts significantly with ETD, with unique features in the structure of loop D indicating potential variations in ETD's binding capabilities compared to other ETs.
Vaginal colonization with virulent and methicillin resistant Staphylococcus aureus among Ugandan women in Labour.
BMC Microbiol
August 2024
Centre for Intervention Science in Maternal and Child Health, University of Bergen, Bergen, Norway.
Article Synopsis
- Staphylococcus aureus (S. aureus) can colonize the human body, especially in the female genital tract, potentially leading to infections in newborns during vaginal delivery.
- A study analyzed 85 S. aureus isolates from women in Uganda, focusing on the presence of virulence factor genes and methicillin resistance.
- Results showed that 15.3% of the isolates had one or more virulence genes, while 55.3% were methicillin-resistant, indicating a notable prevalence of pathogenic strains among the population studied.
Updates on postinfectious skin rashes in pediatric dermatology.
Curr Opin Pediatr
August 2024
Department of Dermatology and Pediatrics, University of California, Davis, California, USA.
Article Synopsis
- This review highlights updates on skin rashes following infections in children, primarily related to the COVID-19 pandemic.
- Key complications discussed include multisystem inflammatory syndrome in children (MIS-C) and reactive infectious mucocutaneous eruption (RIME), which are seen post-SARS-CoV-2 infection but mostly show low mortality rates.
- The review also addresses the increasing antifungal resistance related to Trichophyton indotinae and emphasizes the importance of staying updated on recent management guidelines for various skin conditions in pediatric care.
Line-field confocal optical coherence tomography for real-time differential diagnosis of toxic epidermal necrolysis versus staphylococcal scalded skin syndrome.
Clin Exp Dermatol
November 2024
Dermatology Department, Edouard Herriot University Hospital, Hospices Civils de Lyon, Lyon, France.
The Clinical Characteristics and Antimicrobial Resistance of Isolated from Patients with Staphylococcal Scalded Skin Syndrome (SSSS) in Southwestern China.
Antibiotics (Basel)
May 2024
Department of Dermatology and Venereology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Article Synopsis
- Staphylococcal scalded skin syndrome (SSSS) is a serious skin infection caused by toxins from bacteria, with limited data available from Southwestern China, motivating this study on its clinical and microbiological characteristics.
- The study analyzed 79 SSSS patients over nearly a decade, finding a high prevalence of methicillin-resistant Staphylococcus aureus (MRSA), primarily from community sources, and showed annual variations in the incidence of SSSS.
- Results indicate that while MRSA was fully sensitive to several antibiotics like vancomycin, resistance to penicillin was complete, highlighting the need for prescribing antibiotics based on susceptibility patterns for better treatment outcomes.
Scaling and periorificial crusts in a pediatric patient.
Infection
October 2024
Department of Dermatology, Hospital Universitario y Politécnico La Fe, 106 Fernando Abril Martorell Avenue, Valencia, 46026, Spain.
Article Synopsis
- - A 14-month-old child was diagnosed with Staphylococcal Scalded Skin Syndrome (SSSS), characterized by widespread skin redness, pain, and crusting around the mouth, leading to hospitalization.
- - SSSS primarily affects children and is caused by certain strains of Staphylococcus aureus that release exfoliative toxins, leading to skin blisters typically within 48 hours.
- - Diagnosis is based on clinical evaluation, and treatment typically involves intravenous antibiotics like cloxacillin and electrolyte replacement to manage the condition.
Staphylococcus Scalded Skin Syndrome-Induced Thrombosis Leading to Free Flap Complications: A Case Report and Review.
Cureus
April 2024
Department of Plastic and Reconstructive Surgery, Mater Misericordiae University Hospital, Dublin, IRL.
Article Synopsis
- Staphylococcal scalded skin syndrome (SSSS) is a skin condition caused by toxins from bacteria that leads to blistering and can result in complications like thrombosis, which remains poorly understood. * The article discusses a unique case of free anterolateral thigh flap failure linked to widespread thrombosis in a patient with SSSS, marking it as the first of its kind reported. * The aim is to investigate the connection between thrombophilia, thrombotic events caused by infections, and how these factors contribute to free flap failure, along with reviewing related literature and reported cases.
Unusual Presentation of Staphylococcal Scalded Skin Syndrome in an Elderly Patient With Acute Kidney Injury: A Case Report.
Cureus
March 2024
Department of Dermatology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Article Synopsis
- Staphylococcal Scalded Skin Syndrome (SSSS) leads to skin peeling, primarily affecting infants and, less commonly, immunosuppressed adults or those with kidney issues.
- A case study details a 70-year-old woman with acute kidney injury who experienced extensive skin peeling that began in the armpit and back, spreading to other body parts.
- A skin biopsy confirmed the diagnosis of adult SSSS, and after initiating intravenous antibiotic treatment, the patient's skin lesions improved significantly.
Neonatal Severe Staphylococcal Scalded Skin Syndrome: Management with Autoadhesive Skin Substitute Dressing (Suprathel).
Indian J Pediatr
September 2024
Department of Pediatric Surgery, La Paz Children´s University Hospital, Madrid, Spain.
Streptococcal toxic shock syndrome and multifocal necrotizing fasciitis secondary to staphylococcal scalded skin syndrome in the same patient.
Med Clin (Barc)
June 2024
Servicio de dermatología, HGU Reina Sofía, Murcia, España.
Staphylococcal scalded skin syndrome in neonate: Another face of CA-MRSA.
Indian J Pathol Microbiol
February 2024
Department of Pediatrics, PSG Institute of Medical Sciences and Research (PSGIMSR), Coimbatore, Tamil Nadu, India.
Article Synopsis
- - Staphylococcal scalded skin syndrome (SSSS) is a severe skin condition mostly affecting infants and children, caused by the bacteria Staphylococcus aureus, particularly phage group 71.
- - It typically arises from infections in areas like the nasopharynx, umbilicus, or through superficial injuries, and leads to symptoms such as blisters and skin peeling due to toxins produced by the bacteria.
- - A case study featured an 11-day-old newborn diagnosed with SSSS caused by methicillin-resistant Staphylococcus aureus (MRSA), which was treated successfully with clindamycin after confirming the presence of a virulence gene known as Panton-Valentine leukocidin (
Acute Generalized Exanthematous Pustulosis in a Hemodialysis Patient.
Cureus
December 2023
Internal Medicine, Jackson Memorial Hospital, Miami, USA.
Article Synopsis
- AGEP is a rare skin condition that can occur alongside serious skin rashes and systemic symptoms, especially in patients with existing health issues.
- A 70-year-old woman with end-stage renal disease developed a widespread itchy rash after taking vancomycin and acetaminophen, leading to a biopsy that confirmed AGEP.
- The case emphasizes the importance of considering AGEP in similar patients and the necessity of quick biopsy and blood tests to avoid misdiagnosis and delays in treatment.
Molecular Characteristics and Pathogenicity of Exotoxins.
Int J Mol Sci
December 2023
Department of Zoonoses, Kitasato University School of Veterinary Medicine, Towada 034-8628, Japan.
Article Synopsis
- * It emphasizes the role of exotoxins produced by this pathogen as critical factors in causing infections and food poisoning in humans and animals, listing specific toxins associated with different illnesses, such as foodborne poisoning and toxic shock syndrome.
- * The review aims to provide new insights into the structure, functions, and pathogenicity of both well-known and recently identified exotoxins linked to this pathogen.
Article Synopsis
- - Staphylococcal scalded skin syndrome (SSSS) is a rare but serious condition that can affect premature infants, as shown in a reported case of a preterm newborn with fatal complications from fungemia.
- - The diagnosis of SSSS in this case was confirmed through a skin biopsy, highlighting the difficulty of differentiating it from other conditions based on clinical presentation alone.
- - Early recognition and prompt treatment with supportive care and antimicrobial therapy are crucial for improving outcomes in infants with congenital SSSS to prevent fatal consequences.
'Sad Man' Facies in a Preterm Neonate with Staphylococcal Scalded Skin Syndrome.
Indian J Pediatr
January 2025
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110029, India.
Bullous Pemphigoid in a Centenarian Male Simulating Toxic Epidermal Necrolysis.
Cureus
September 2023
Dermatology, Lexington Veterans Affairs (VA) Health Care System, Lexington, USA.
Article Synopsis
- Bullous pemphigoid (BP) is a common autoimmune blistering disease that typically causes large, tense blisters, and this report details an unusual case in a 103-year-old male with acute BP symptoms.
- The patient exhibited severe skin lesions covering 12% of his body, which initially suggested other conditions like toxic epidermal necrolysis (TEN) and Staphylococcal scalded skin syndrome.
- Accurate diagnosis through clinical, histological, and immunofluorescence tests is crucial, as atypical presentations of blistering diseases can complicate treatment and patient care.
Methicillin-resistant Staphylococcus aureus-induced staphylococcal scalded skin syndrome in a preterm infant, and subsequent toxigenic analysis.
J Dermatol
December 2023
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Stevens-johnson Syndrome and Toxic Epidermal Necrolysis: An Overview of Diagnosis, Therapy Options and Prognosis of Patients.
Recent Adv Inflamm Allergy Drug Discov
November 2023
Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133 207, Haryana, India.
Article Synopsis
- Stevens-Johnson Syndrome (SJS) and Toxic-Epidermal Necrolysis (TEN) are serious, medication-induced skin conditions affecting mucus membranes and the epidermis, with annual incidence rates of about 1 to 2 per million people; SJS has a mortality rate of 1-5%, while TEN has a much higher rate of 25-35%.
- Both conditions are characterized by severe skin detachment, mucocutaneous discomfort, and potential long-term effects on survivors, particularly in the elderly, who may experience reduced quality of life and life expectancy.
- The majority of cases are caused by specific drugs, including carbamazepine and sulfonamides,
Recurrent staphylococcal scalded skin syndrome in a 20-month old-A case report.
Clin Case Rep
August 2023
Sovah Pediatrics-Danville Danville Virginia USA.
Article Synopsis
- A 20-month-old child with atopic dermatitis developed recurrent skin lesions resembling Staphylococcal Scalded Skin Syndrome (SSSS).
- SSSS is a skin condition caused by exfoliative toxins, primarily affecting young children.
- The paper emphasizes the need for quick recognition and treatment of SSSS, especially in patients with a history of atopic dermatitis, to promote healing.
Fast, bedside diagnosis of toxic epidermal necrolysis using ex vivo confocal laser scanning microscopy: A retrospective study.
J Eur Acad Dermatol Venereol
January 2024
Department of Dermatology and Venereology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Article Synopsis
- Toxic epidermal necrolysis (TEN) is a severe skin condition often triggered by medications, and distinguishing it from similar conditions quickly is essential for appropriate treatment.* -
- This study compares the effectiveness of ex vivo confocal laser scanning microscopy (CLSM) to standard histopathology techniques in diagnosing TEN from skin samples.* -
- The results show that ex vivo CLSM is both accurate and fast, achieving high sensitivity and specificity, making it a valuable tool for quick TEN diagnosis in emergency situations.*
Associated Outcomes of Different Intravenous Antibiotics Combined with 2% Mupirocin Ointment in the Treatment of Pediatric Patients with Staphylococcal Scalded Skin Syndrome.
Clin Cosmet Investig Dermatol
June 2023
Department of Dermatology and Venereology, Candidate Branch of National Clinical Research Centre for Skin and Immune Diseases, The First Affiliated Hospital of Gannan Medical University, Ganzhou, People's Republic of China.
Article Synopsis
- The study aimed to evaluate the treatment duration, influencing factors, and costs for different intravenous antibiotics alongside 2% mupirocin ointment in treating staphylococcal scalded skin syndrome (SSSS).
- Researchers analyzed data from 253 patients, considering factors like age, WBC count, and CRP levels, using various statistical tests to assess treatment effectiveness and costs.
- Results indicated that oxacillin had high sensitivity, clindamycin had high resistance, and older children generally had shorter treatment durations, while higher WBC and CRP levels were linked to longer treatment times.
Staphylococcal Infections and Neonatal Skin: Data from Literature and Suggestions for the Clinical Management from Four Challenging Patients.
Antibiotics (Basel)
March 2023
Neonatal Intensive Care Unit, "Bambino Gesù" Children's Hospital IRCCS, 00165 Rome, Italy.
Article Synopsis
- * This review analyzes four specific cases of neonatal blistering diseases linked to Staphylococcal infections, including bullous impetigo and scalded skin syndrome, emphasizing tailored clinical management.
- * Due to the absence of specific guidelines for treating these infections in neonates, treatment should be personalized based on the extent of the disease and any existing skin issues, fostering a collaborative care approach.