2,319 results match your criteria: "Staphylococcal Meningitis"

Microbiology reference laboratories perform a crucial role within public health systems. This role was especially evident during the COVID-19 pandemic. In this Viewpoint, we emphasise the importance of microbiology reference laboratories and highlight the types of digital data and expertise they provide, which benefit national and international public health.

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Bacterial meningitis causes significant morbidity and mortality in infants. Lumbar punctures are often deferred until the results of blood cultures are known and sometimes not considered, making this population susceptible to a missed diagnosis. There are few studies describing the epidemiology of neonatal meningitis in quaternary neonatal intensive care unit settings.

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Dog bites are a source of zoonotic infections to humans, such as pasteurellosis and meningitis. Zoonotic bacterial identification and their antibiotic susceptibility assessment are key towards the successful management of such infections. This study isolated and identified zoonotic bacterial species from the oral cavities of indigenous dogs and also determined their antibiotic susceptibility profile.

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Purpose: Neonatal bacterial meningitis (NBM) is a serious disease with high morbidity and mortality. This study aimed to establish a foundation for the selection of empirical antibiotics for NBM through an analysis of pathogen distribution and shift in antimicrobial resistant pattern.

Patients And Methods: A retrospective cohort study on culture confirmed NBM from 2005 to 2022.

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Streptococcus suis is a worldwide pathogen that impacts the swine industry, causing severe clinical signs, including meningitis and arthritis, in postweaning piglets. A key virulence mechanism of S. suis is biofilm formation, which improves its persistence and resistance to external factors.

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The two-component system ArlRS is essential for wall teichoic acid glycoswitching in .

mBio

November 2024

Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

is among the leading causes of hospital-acquired infections. Critical to biology and pathogenesis are the cell wall-anchored glycopolymers wall teichoic acids (WTA). Approximately one-third of isolates decorates WTA with a mixture of α1,4- and β1,4--acetylglucosamine (GlcNAc), which requires the dedicated glycosyltransferases TarM and TarS, respectively.

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Background: Haemophilus influenza persists as a well-known root of ill health in children throughout the entire world. Before the introduction of the vaccine, Haemophilus influenza remained a well-known and eminent source of septic arthritis, pneumonia, and epiglottitis. Haemophilus influenza, Neisseria meningitides, and staphylococcus pneumonia spreads through respiratory droplets and cause diseases such as meningitis, pneumonia, and other secondary infections related to respiratory diseases.

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Background: Postoperative intracranial neurosurgical infections (PINI) complicate < 5% neurosurgeries. Scarce attention was dedicated to the extension and characteristics of its antimicrobial management considering their high morbidity, not negligible mortality, delayed hospital stay and increased healthcare costs.

Methods: We analyzed retrospectively (2014-2023) 162 PINI from eight Spanish third-level academic hospitals.

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Effect of Staphylococcal Decolonization Regime on Post-Craniotomy Meningitis.

Acta Neurochir Suppl

November 2024

Department of Neurological Sciences, Christian Medical College, Vellore, India.

Post craniotomy meningitis (PCM), an uncommon complication following craniotomy can be categorized as either bacterial meningitis (BM) or aseptic meningitis (AM) based on the results of CSF culture. Staph. aureus is a common causative organism.

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Our objective was to evaluate the ramifications of the 2019 coronavirus disease (COVID-19) pandemic on the microbial profile and antimicrobial resistance patterns of bacteria isolated from cerebrospinal fluid (CSF) specimens of patients with bacterial meningitis. We conducted a retrospective analysis of laboratory results and clinical records about positive CSF cultures reported by the SPARSS network from 2017 to 2023. The study covered three distinct periods: January 2017 to December 2019 (before the COVID-19 pandemic), January 2020 to December 2022 (during the COVID-19 pandemic), and January 2023 to December 2023 (after the COVID-19 pandemic), with a total of 5793 CSF isolates collected.

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Infantile bacterial meningitis combined with sepsis caused by : A case report.

World J Clin Cases

November 2024

Department of Pediatrics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang 621000, Sichuan Province, China.

Background: (SGSP) is a rare pathogen responsible for infant sepsis and meningitis and is potentially overlooked because it is not included in routine group B streptococcal screenings. Hence, we present a case of SGSP-induced infant meningitis and sepsis, accompanied by bronchopneumonia induced by multidrug-resistant (MRSA), providing insights into the identification, management, and prognosis of this bacterial infection.

Case Summary: A 45-day-old female infant presented with two episodes of high fever (maximum temperature: 39.

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Article Synopsis
  • Staphylococcus aureus (SA) is a significant bacterial pathogen that leads to serious infections in humans, causing conditions like meningitis, endocarditis, and sepsis.
  • The literature review focuses on the immune responses to SA and methicillin-resistant Staphylococcus aureus (MRSA), highlighting their mechanisms to evade the immune system and exploring vaccine and immunotherapy options.
  • Promising vaccine approaches such as toxoid vaccines, along with antitoxin and immunomodulating therapies, show potential, but further research in human clinical studies is necessary to ensure safety and effectiveness.
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Background: Antimicrobial resistance is currently one of the most significant threats to medical science, necessitating the exploration of new antimicrobial agents. Methicillin-resistant (MRSA) can lead to various severe conditions such as endocarditis, meningitis, abscesses, and sepsis, and conventional antibiotics such as beta-lactams are ineffective for treating these diseases. Therefore, it is imperative to search for novel chemical substances with antimicrobial effects against MRSA.

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Frequency, risk factors, and outcome of neonatal meningitis in sepsis.

Pak J Med Sci

October 2024

Dr. Ayaz Ur Rehman, MBBS Department of Pediatric Medicine and Child Health, Aga Khan University Hospital, Karachi, Pakistan.

Article Synopsis
  • * Out of 209 neonates diagnosed with sepsis, 59 (28.2%) had meningitis, with notable risk factors including lower birth weight, prolonged hospital stays, and symptoms like fever and vomiting.
  • * Although meningitis is common in these cases, the mortality rate was low (3.4%), and bacterial cultures, especially for Methicillin-sensitive Staphylococcus aureus (MSSA), played a key role in understanding the disease's bacterial causes.
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Article Synopsis
  • Infective endocarditis (IE) is a serious infection that causes inflammation of the heart's inner lining, often increasing in patients receiving hemodialysis (HD).
  • A case study describes a 46-year-old obese male with a history of diabetes and renal disease who faced severe symptoms after missing dialysis sessions, including altered mental status and indications of septic shock.
  • The case emphasizes the need for urgent medical intervention and collaboration among healthcare teams to stabilize the patient and investigate potential infections linked to his condition.
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Article Synopsis
  • Guidelines suggest giving kids with bacterial meningitis a medicine called ceftriaxone in certain doses.
  • Researchers studied how well this medicine enters the brain's protective fluid in kids and found that the once-daily method works better than the twice-daily method for some bacteria.
  • They learned that while the once-a-day dose is better, neither dose worked well enough for treating all kinds of meningitis.
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Background: The management of recurrent Rathke's cleft cysts (RCCs) remains challenging. The off-label application of steroid-eluting bioabsorbable or nonabsorbable intracystic stents has been recently described. Early outcomes and complications of this treatment have been described as well, but long-term data are lacking.

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Glycan-specific IgM is critical for human immunity to Staphylococcus aureus.

Cell Rep Med

September 2024

Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands; Netherlands Reference Center for Bacterial Meningitis, Amsterdam UMC, location AMC, Amsterdam, the Netherlands; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, The Netherlands. Electronic address:

Staphylococcus aureus is a major human pathogen, yet the immune factors that protect against infection remain elusive. High titers of opsonic IgG antibodies, achieved in preclinical animal immunization studies, have consistently failed to provide protection in humans. Here, we investigate antibody responses to the conserved S.

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Introduction: This study aims to investigate the changing epidemiology and antimicrobial susceptibility of bacteria isolated from cerebrospinal fluid (CSF) in the Shandong region.

Methodology: We conducted a retrospective analysis of bacterial distribution and resistance patterns in CSF samples, utilizing data from the SPARSS network and analyzed with WHONET 5.6 software.

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The bacterium Streptococcus pneumoniae has become a leading cause of meningitis, sepsis, and bacterial pneumonia worldwide, with increased prevalence of antibiotic-resistant serotypes serving to exacerbate the issue. The main factor responsible for colonization and immune response escape in pneumococcal infections is the secreted molecule pneumolysin, which is a subset within a family of related toxins that form transmembrane pores in biological membranes through cholesterol recognition and binding. The conserved activity and structure of pneumolysin between all observed S.

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Background: Antimicrobial resistance increasingly impacts paediatric mortality, particularly in resource-constrained settings. We aimed to evaluate the susceptibility profiles of bacteria causing infections in children from the Western Pacific region.

Methods: We conducted a systematic review and meta-analysis of bacteria responsible for common infections in children.

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Article Synopsis
  • MRSA (Methicillin-resistant Staphylococcus aureus) is a common pathogen known for causing serious infections in hospitals, but there's been a rise in infections from the community as well.
  • A case is presented of a 63-year-old woman who, after lifting a heavy object, experienced altered mental status and neck stiffness, ultimately diagnosed with MRSA bacteremia and cervical epidural abscess.
  • The case highlights the importance of identifying the source of MRSA infections for effective treatment and underscores the need for thorough assessment due to MRSA's serious health risks.
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Cochlear Implant Infections.

Infect Dis Clin North Am

December 2024

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, University of Florida, 1345 Center Drive, M2-228 MSB, Box 100264, Gainesville, FL 32610-0264, USA. Electronic address:

Cochlear implants (CIs) are associated with a range of infections. These infections present unique considerations because of their position relative to the respiratory tract and the central nervous system, as well as the propensity for biofilms to form on CIs. This article reviews infections related to CIs, including otitis media, mastoiditis, meningitis, and deep CI infection.

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A 73-year-old man who previously underwent transsphenoidal surgery for a Rathke's cleft cyst presented with headache and fever. Ophthalmological examination revealed the progression of visual impairment. Cerebral magnetic resonance imaging revealed a cystic mass in the sellar and suprasellar regions with rim-like enhancement.

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