3 results match your criteria: "St. Vincent's University Hospital (M.B.[Affiliation]"
A Risk Score Including Carotid Plaque Inflammation and Stenosis Severity Improves Identification of Recurrent Stroke.
Stroke
March 2020
From the UCD Neurovascular Clinical Science Unit, Stroke Service/Department of Neurology, Mater University Hospital, Dublin, Ireland (P.J.K., N.G., G.H., M.M., J.M., S.M.).
Background and Purpose- In randomized trials of symptomatic carotid endarterectomy, only modest benefit occurred in patients with moderate stenosis and important subgroups experienced no benefit. Carotid plaque F-fluorodeoxyglucose uptake on positron emission tomography, reflecting inflammation, independently predicts recurrent stroke. We investigated if a risk score combining stenosis and plaque F-fluorodeoxyglucose would improve the identification of early recurrent stroke.
View Article and Find Full Text PDFLiraglutide Attenuates Preestablished Atherosclerosis in Apolipoprotein E-Deficient Mice via Regulation of Immune Cell Phenotypes and Proinflammatory Mediators.
J Pharmacol Exp Ther
September 2019
School of Biomolecular and Biomedical Science (R.B., O.B.) and School of Medicine (S.C., S.K., E.P.B., F.C.M.), Diabetes Complications Research Centre, and Mass Spectrometry Resource (E.T.D.), University College Dublin (UCD) Conway Institute, UCD, Belfield, School of Public Health, Physiotherapy and Sports Science, UCD, Belfield (G.L., M.E.O'R.), and Vascular Surgery, St. Vincent's University Hospital (M.B., S.S.), Dublin, Ireland
We have shown that the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide (Lir) inhibits development of early atherosclerosis in vivo by modulating immune cell function. We hypothesized that Lir could attenuate pre-established disease by modulating monocyte or macrophage phenotype to induce atheroprotective responses. Human atherosclerotic plaques obtained postendarterectomy and human peripheral blood macrophages were treated ex vivo with Lir.
View Article and Find Full Text PDFCarotid Plaque Inflammation Imaged by F-Fluorodeoxyglucose Positron Emission Tomography and Risk of Early Recurrent Stroke.
Stroke
July 2019
Department of Radiology (E.K., M. O'Connell), University College Dublin, Ireland.
Background and Purpose- Plaque inflammation contributes to stroke and coronary events. F-fluorodeoxyglucose (FDG) positron emission tomography (PET) identifies plaque inflammation-related metabolism. Almost no prospective data exist on the relationship of carotid F-FDG uptake and early recurrent stroke.
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