1 results match your criteria: "St. Vincent's Hospital and St. Vincent's Institute of Medical Research[Affiliation]"
Dexamethasone regulation of parathyroid hormone-related protein (PTHrP) expression in a squamous cancer cell line.
Mol Cell Endocrinol
May 1994
The University of Melbourne Department of Medicine, St. Vincent's Hospital and St. Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
Dexamethasone regulation of PTHrP expression has been studied in an epidermal squamous cancer cell line COLO 16, which secretes immunoreactive PTHrP into conditioned medium. Dexamethasone was found to suppress PTHrP expression in a time- and dose-dependent manner, which was reversible upon removal of dexamethasone. The half-maximal effective concentration of dexamethasone was 1 nM and an effect of dexamethasone on PTHrP mRNA was first observed after 2 h of treatment, with maximal inhibition by 6 h.
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