Comparison of passive targeted delivery of inorganic and organic nanocarriers among different types of tumors.

In this study, we have considered four types of nanoparticles (NPs): polylactic acid (PLA), gold (Au), calcium carbonate (CaCO), and silica (SiO) with similar sizes (TEM: 50-110 nm and DLS: 110-140 nm) to examine their passive accumulation in three different tumors: colon (CT26), melanoma (B16-F10), and breast (4T1) cancers. Our results demonstrate that each tumor model showed a different accumulation of NPs, in the following order: CT26 > B16-F10 > 4T1. The Au and PLA NPs were evidently characterized by a higher delivery efficiency in case of CT26 tumors compared to CaCO and SiO NPs.

Synthesis under Normal Conditions and Morphology and Composition of AlF Nanowires.

AlF has interesting electrophysical properties, due to which the material is promising for applications in supercapacitors, UV coatings with low refractive index, excimer laser mirrors, and photolithography. The formation of AlF-based nano- and micro-wires can bring new functionalities to AlF material. AlF nanowires are used, for example, in functionally modified microprobes for a scanning probe microscope.

Efficient Broadband Light-Trapping Structures on Thin-Film Silicon Fabricated by Laser, Chemical and Hybrid Chemical/Laser Treatments.

Light-trapping structures formed on surfaces of various materials have attracted much attention in recent years due to their important role in many applications of science and technology. This article discusses various methods for manufacturing light-trapping "black" silicon, namely laser, chemical and hybrid chemical/laser ones. In addition to the widely explored laser texturing and chemical etching methods, we develop a hybrid chemical/laser texturing method, consisting in laser post-texturing of pyramidal structures obtained after chemical etching.

Recording Methods and the Capabilities of Modern Respiratory Rate Monitoring Devices (literature review).

Determination of respiratory rate is a necessary task in assessing the state of health in humans. This review provides a description of modern devices used for recording and monitoring respiratory rate. The advantages and disadvantages of the principles of operation of these devices are discussed.

Microminiaturization of Multichannel Multifrequency Radiographs.

Due to the COVID-19 epidemic, the challenge of introducing methods for investigating patients reducing or eliminating the probability of infection of medical staff is currently relevant. This article provides an analytical review of new technological approaches to organizing the work of medical personnel in carrying out auscultation of patients with COVID-19. The development and approval of such technologies is shown to have started around the world.

[SPECIFIC ASPECTS OF THE LEGISLATIVE CONSOLIDATION OF THE INSTITUTION OF EARLY CARE FOR CHILDREN WITH DISABILITIES].

For the purposes of this work, children with disabilities include disabled children or children aged 0 to 8 years who are not recognized as disabled in the prescribed manner, but who have temporary or permanent deviations in physical and (or) mental development (hereinafter - children with disabilities). The legislative basis for the implementation of the rights and opportunities of children with disabilities and their families is constituted by constitutional provisions that enshrine state guarantees for the protection of childhood, motherhood, paternity, family (part 1 of article 38, paragraph "g.1" of part 1 of article 72 of the Constitution of the Russian Federation).

Control over the Surface Properties of Zinc Oxide Powders via Combining Mechanical, Electron Beam, and Thermal Processing.

The surface properties of zinc oxide powders prepared using mechanical activation, electron beam irradiation, and vacuum annealing, as well using combinations of these types of treatments, were studied using X-ray photoelectron spectroscopy. The structure of the obtained materials was studied by an X-ray diffraction technique and by scanning electron microscopy. We found that over five hours of grinding in an attritor, the size of nanocrystals decreases from 37 to 21 nm, and microdeformations increase from 0.

The Canonical Table of the Genetic Code as a periodic system of triplets.

The Canonical Table of the Genetic Code (CTGC) is constructed theoretically on the basis of the similarity of PFs (PF) of proteins with the conformation of 4-arc chain graphs (Karasev, 2019). Of the 64 conformations of the graph, specified by the position of the connectivity edges, and the matrices of 6 variables (x … x), x = (0, 1), 4 blocks of 16 elements each were formed. Then they were coded in the form of triplets based on the correspondence of pairs of variables to four letters of the code: 00 = C, 01 = U, 10 = G, 11 = A, and supplemented based on the known triplet-amino acid assignment.

An ontology-based approach to the analysis of the acid-base state of patients at operative measures.

Researchers working in various domains are focusing on extracting information from data sets by data mining techniques. However, data mining is a complicated task, including multiple complex processes, so that it is unfriendly to non-computer researchers. Due to the lack of experience, they cannot design suitable workflows that lead to satisfactory results.

Reconfigurable monitoring for telecommunication networks.

This article addresses the monitoring problem of the telecommunication networks. We consider these networks as multilevel dynamic objects. It shows that reconfigurable systems are necessary for their monitoring process in real life.

Formation of a Complex Topologies of SAW-Based Inertial Sensors by Laser Thin Film Local Evaporation.

Originally, sensors based on surface acoustic waves are fabricated using photolithography, which becomes extremely expensive when a small series or even single elements are needed for the research. A laser thin film local evaporation technique is proposed to substitute the photolithography process in the production of surface acoustic wave based inertial sensors prototypes. To estimate its potential a prototype of a surface acoustic wave gyroscope sensing element was fabricated and tested.

Precision Angle Measurement Systems on the Basis of Ring Laser Gyro.

The main application of a ring laser gyroscope is navigation. It is currently the most widely used device for strapdown inertial navigation systems. However, it is also applicable for high-precision angle metrology systems.

Assessment of the Status of Patients with Parkinson's Disease Using Neural Networks and Mobile Phone Sensors.

Parkinson's disease (PD) is one of the most common chronic neurological diseases and one of the significant causes of disability for middle-aged and elderly people. Monitoring the patient's condition and its compliance is the key to the success of the correction of the main clinical manifestations of PD, including the almost inevitable modification of the clinical picture of the disease against the background of prolonged dopaminergic therapy. In this article, we proposed an approach to assessing the condition of patients with PD using deep recurrent neural networks, trained on data measured using mobile phones.

Data on the application of the molecular vector machine model: A database of protein pentafragments and computer software for predicting and designing secondary protein structures.

Based on ideas about the molecular vector machine of proteins [1], a database of protein pentafragments has been created and algorithms have been proposed for predicting the secondary structure of proteins according to their primary structure and for designing the primary protein structure for a given secondary structure that it takes on. A comprehensive software suite (Predicto @ Designer) has been developed using the pentafragments database and the said algorithms. For the proteins used to create the pentafragments database, a high accuracy (close to 100%) in predicting the secondary protein structure as well as good prospects for its use for designing secondary structures of proteins have been demonstrated.

A model of molecular vector machine of proteins.

Based on the analysis of NH⋯OC bond region of the proteins pentafragments using the quantum chemistry representations, a group of 20 vectors of action has been isolated. These vectors of action are reconstructed by a group of 20 side chains of amino acids being the irreducible representations of vectors. As a result, a model of molecular vector machine of proteins (MVM) has been proposed.

Co-morbidity with hypertrophic osteoarthropathy: A possible Iron Age Sarmatian case from the Volga steppe of Russia.

Purpose: Hypertrophic osteoarthropathy (HOA) is a condition that can be inherited or acquired. It causes diffuse periosteal new bone formation on the long bones, with a predilection for the appendicular skeleton. When acquired, it is a nonspecific indicator of systemic disease that arises following a primary condition.

3D laser nano-printing on fibre paves the way for super-focusing of multimode laser radiation.

Multimode high-power laser diodes suffer from inefficient beam focusing, leading to a focal spot 10-100 times greater than the diffraction limit. This inevitably restricts their wider use in 'direct-diode' applications in materials processing and biomedical photonics. We report here a 'super-focusing' characteristic for laser diodes, where the exploitation of self-interference of modes enables a significant reduction of the focal spot size.

[Recombinant small heat shock protein from Acholeplasma laidlawii increases the Escherichia coli viability in thermal stress by selective protein rescue].

In both prokaryotes and eukaryotes, the survival at temperatures considerably exceeding the optimum is supported by intense synthesis of the so-called heat shock proteins (HSPs), which act to overcome the adverse effects of heat stress. Among mycoplasmas (class Mollicutes), which have significantly reduced genomes, only some members of the Acholeplasmataceae family possess small HSPs of the α-crystallin type. Overproduction of a recombinant HSP IbpA (Hsp20) from the free-living mycoplasma Acholeplasma laidlawii was shown to increase the resistance of Escherichia coli to short-term heat shock.

Slow passage through thresholds in quantum dot lasers.

A turn on of a quantum dot (QD) semiconductor laser simultaneously operating at the ground state (GS) and excited state (ES) is investigated both experimentally and theoretically. We find experimentally that the slow passage through the two successive laser thresholds may lead to significant delays in the GS and ES turn ons. The difference between the turn-on times is measured as a function of the pump rate of change ɛ and reveals no clear power law.

Thio Derivatives of 2(5H)-Furanone as Inhibitors against Bacillus subtilis Biofilms.

Gram-positive bacteria cause a wide spectrum of infectious diseases, including nosocomial infections. While in the biofilm, bacteria exhibit increased resistance to antibiotics and the human immune system, causing difficulties in treatment. Thus, the development of biofilm formation inhibitors is a great challenge in pharmacology.

Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones.

Gram-positive bacteria can cause various infections including hospital-acquired infections. While in the biofilm, the resistance of bacteria to both antibiotics and the human immune system is increased causing difficulties in the treatment. Bacillus subtilis, a non-pathogenic Gram-positive bacterium, is widely used as a model organism for studying biofilm formation.

Pulse mode of operation of a spherical piezoceramic transducer filled with liquid and having a correcting electric circuit.

By means of a computational method, the possibility of radiating a short acoustic pulse by a transducer in the form of a piezoceramic sphere internally filled with liquid is investigated. An electric inductive-resistive circuit is connected to the electric input of the transducer. Solution is obtained based on scheme-analogs theory for piezoceramic transducers, and spectral Fourier transform theory.

Classification of sparse high-dimensional vectors.

We study the problem of classification of d-dimensional vectors into two classes (one of which is 'pure noise') based on a training sample of size m. The main specific feature is that the dimension d can be very large. We suppose that the difference between the distribution of the population and that of the noise is only in a shift, which is a sparse vector.

Analysis of blood pressure-heart rate feedback regulation under non-stationary conditions: beyond baroreflex sensitivity.

The feedback regulation of blood pressure and heart rate is an important indicator of human autonomic function usually assessed by baroreflex sensitivity (BRS). We suggest a new method yielding a higher temporal resolution than standard BRS methods. Our approach is based on a regression analysis of the first differences of inter-heartbeat intervals and blood pressure values.