4 results match your criteria: "St. Michael's Hospital and Department of Laboratory Medicine and Pathobiology[Affiliation]"
Autophagy and its current relevance to the diagnosis and clinical management of esophageal diseases.
Ann N Y Acad Sci
October 2016
Cumming School of Medicine, University of Calgary, Calgary, Canada.
Autophagy is an evolutionarily conserved cell survival program that degrades dysfunctional organelles and misfolded or long-lived proteins through the formation of lysosomes. Basal autophagy helps to maintain cellular homeostasis, while additional autophagy can be induced under cellular stress conditions. Autophagy has shown to be involved in a variety of diseases, such as inflammation, autoimmune diseases, degeneration, and cancer.
View Article and Find Full Text PDFA case report of unusually long lag time between immunotactoid glomerulopathy (itg) diagnosis and diffuse large B-cell lymphoma (DLBCL) development.
BMC Nephrol
September 2016
Department of Laboratory Medicine, St. Michael's Hospital and Department of Laboratory Medicine and Pathobiology, Univesity of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.
Article Synopsis
- Immunotactoid glomerulopathy (ITG) is a rare kidney condition linked to blood disorders, where treatment of underlying malignancies can reverse kidney issues.
- A 55-year-old woman with diabetes and ITG initially showed no signs of lymphoma, but two years later she was diagnosed with diffuse large B-cell lymphoma.
- After chemotherapy and radiation, she achieved complete remission of both lymphoma and ITG, highlighting the importance of monitoring patients with ITG for potential blood cancers.
Blood conservation in neurosurgery: erythropoietin and autologous donation.
Can J Neurol Sci
September 2014
1Injury Prevention Research,St-Michael's Hospital, University of Toronto,Toronto,ON,Canada.
Background: Neurosurgery may involve significant blood loss and frequently requires allogeneic red blood cell (RBC) transfusion. Preoperative recombinant erythropoietin (EPO) may be used to improve erythroid status and recovery, and used either alone or in combination with preoperative autologous donation (PAD) it may reduce exposure to allogeneic RBC. We wished to study the use of EPO with and without PAD and the risk of RBC transfusion in neurosurgery.
View Article and Find Full Text PDFA clinical and pathological variant of acute transplant glomerulopathy.
Case Rep Pathol
October 2014
Renal Transplant Program, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8 ; Division of Nephrology, St. Michael's Hospital, 61 Queen Street East, Room No. 9-118, Toronto, ON, Canada M5C 2T2.
Acute transplant glomerulopathy transplant glomerulopathy (TG) is a common cause of late renal allograft loss. We describe a unique case of a renal transplant recipient who developed rapid-onset nephrotic-range proteinuria and acute kidney injury secondary to C4d negative acute TG. Two courses of intravenous Rituximab resulted in significant improvement in proteinuria and allograft function.
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