38 results match your criteria: "St. Mary's Hospital: Mint Wing[Affiliation]"

Less than 50% of variation in HDL cholesterol between and within individuals, is explained by established predictors.

Atherosclerosis

January 2006

Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, St. Mary's Hospital, Mint Wing 2nd Floor, London W2 1NY, UK.

Variation in serum high density lipoprotein cholesterol (HDL-C) concentrations is believed to be largely explained by triglycerides, but this has been mainly explored in cross-sectional analyses. Eight hundred and eighty one white male participants in a health screening program attended on a total of 2158 occasions for measurements that included fasting HDL-C, low density lipoprotein cholesterol (LDL-C) and homeostasis model assessment insulin resistance (HOMA-R). Baseline, change between-visit and repeated-measures regression models were used to analyse predictors of between- and within-individual variation in HDL-C.

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The nature of inhibition of steroid sulphatase activity by tibolone and its metabolites.

J Steroid Biochem Mol Biol

February 2005

Endocrinology and Metabolic Medicine, Imperial College Faculty of Medicine, Mint Wing, 2nd Floor, St. Mary's Hospital, London W2 1NY, UK.

Tibolone is used for hormone replacement therapy and acts in a tissue-specific manner being oestrogenic on CNS and bone but not on breast tissues or endometrium. The ability of tibolone and its metabolites to inhibit steroid sulphatase (STS) activity has a crucial role in regulating its tissue-specific effects. In this study, we have examined the ability of tibolone and its non-sulphated and sulphated metabolites to inhibit STS activity in different enzyme preparations and in intact cells.

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Loss of beta cell function as fasting glucose increases in the non-diabetic range.

Diabetologia

July 2004

Department of Endocrinology and Metabolic Medicine, Division of Medicine, Faculty of Medicine, Imperial College London, St. Mary's Hospital, Mint Wing 2nd Floor, London, W2 1PG, UK.

Aims/hypothesis: Our aim was to define the level of glycaemia at which pancreatic insulin secretion, particularly first-phase insulin release, begins to decline.

Methods: Plasma glucose and insulin concentrations were measured during an IVGTT in 553 men with non-diabetic fasting plasma glucose concentrations. In 466 of the men C-peptide was also estimated.

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Objective: To assess whether method of administration of a standard urinary symptom questionnaire alters the relationship of symptoms with urodynamic diagnoses.

Design: Randomised crossover study.

Setting: Tertiary Urogynaecology Unit, London, UK.

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Thromboelastography, whole-blood haemostasis and recurrent miscarriage.

Hum Reprod

December 2003

Faculty of Medicine, Department of Obstetrics and Gynaecology, Imperial College London, St Mary's Hospital, Mint Wing, South Wharf Road, London W2 1PG, UK.

Background: Some cases of recurrent miscarriage have a thrombotic basis. Thromboelastography is a rapid, reproducible test of whole-blood haemostasis.

Methods: Thromboelastography was performed in 494 consecutive, non-pregnant women (median age 35 years; range 21-48) with a history of miscarriages at <12 weeks gestation (median 4; range 3-12) and 55 parous women (median age 33 years; range 20-41) with no history of pregnancy loss.

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Breast cancer and HRT: general practice must not pick up the wrong pieces.

Maturitas

October 2003

Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, Mint Wing, St. Mary's Hospital, Praed Street, London W2 1NY, UK.

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Background: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder affecting women of reproductive age. The syndrome is characterized by a combination of polycystic ovarian morphology, clinical features and biochemical indices. The objective of this prospective observational study was to investigate the relationship between the total ovarian volume and the ovarian stromal volume, measured using a three-dimensional (3D) ultrasound scan, with biochemical indices of PCOS.

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Metformin therapy in the management of polycystic ovary syndrome: endocrine, metabolic and reproductive effects.

Gynecol Endocrinol

October 2001

Department of Reproductive Medicine and Science, Imperial College School of Medicine, St Mary's Hospital, Norfolk Place, Mint Wing, London W2 1PG, UK.

Polycystic ovary syndrome (PCOS) is a convergence of multisystem endocrine derangements. Impairment in insulin metabolism is a prominent feature of the syndrome and appears to play a key pathogenetic role precipitating the cascade of other disorders associated with PCOS. Recent studies report that insulin-sensitizing agents, such as metformin, reduce hyperinsulinemia, reverse the endocrinopathy of PCOS and normalize endocrine, metabolic and reproductive functions, leading to the resumption of menstrual cyclicity and ovulation.

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Screening for diabetes in pregnancy.

J R Soc Med

October 2001

Department of Endocrinology and Metabolic Medicine, Imperial College School of Medicine, Mint Wing, St Mary's Hospital, Praed Street, London W2 1NY, UK.

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Intrauterine haematomas in a recurrent miscarriage population.

Hum Reprod

September 2001

Department of Reproductive Science and Medicine, Imperial College School of Medicine at St Mary's Hospital, Mint Wing, South Wharf Road, London W2 INY, UK.

Background: This study examines the effect of intrauterine haematomas (IUH) discovered during early pregnancy ultrasound scanning in patients with recurrent miscarriage. Previous studies of IUHs have reported conflicting findings, and none studied women with recurrent miscarriage.

Methods: A total of 341 women with a viable pregnancy was included.

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There is a high incidence of end-stage renal failure (ESRF) of undetermined cause in the Indo-Asian population of the UK. We studied patients presenting from the district of Brent and Harrow, which has a large Indo-Asian community, and whose renal services are largely provided by our centre. The diagnosis and ethnicity of patients starting renal replacement therapy and/or undergoing renal biopsy were collated.

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Cardiovascular effects of oestrogens.

J Steroid Biochem Mol Biol

November 2000

Endocrinology and Metabolic Medicine, Imperial College School of Medicine, Mint Wing, St Mary's Hospital, Praed Street, W2 1NY, London, UK.

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The risks associated with pregnancy in women aged 35 years or older.

Hum Reprod

November 2000

Section of Endocrinology and Metabolic Medicine (The Mint Wing), ICSM at St Mary's, Department of Pathology, St Mary's Hospital, Paddington, London, W2 1NY, UK.

The obstetric risks of adverse outcome during pregnancy in women aged > or =35 years were quantified using a retrospective analysis of data from 385 120 singleton pregnancies in the North West Thames Region, UK, between 1988 and 1997. A comparison of pregnancy outcome was made on the basis of maternal age at delivery: 18-34 years (n = 336 462), 35-40 years (n = 41 327) and women aged > 40 years (n = 7331). Women aged <18 years (n = 5246) were excluded from the study.

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