38 results match your criteria: "St. Mary's Hospital: Mint Wing[Affiliation]"
Atherosclerosis
January 2006
Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, St. Mary's Hospital, Mint Wing 2nd Floor, London W2 1NY, UK.
Variation in serum high density lipoprotein cholesterol (HDL-C) concentrations is believed to be largely explained by triglycerides, but this has been mainly explored in cross-sectional analyses. Eight hundred and eighty one white male participants in a health screening program attended on a total of 2158 occasions for measurements that included fasting HDL-C, low density lipoprotein cholesterol (LDL-C) and homeostasis model assessment insulin resistance (HOMA-R). Baseline, change between-visit and repeated-measures regression models were used to analyse predictors of between- and within-individual variation in HDL-C.
View Article and Find Full Text PDFJ Steroid Biochem Mol Biol
February 2005
Endocrinology and Metabolic Medicine, Imperial College Faculty of Medicine, Mint Wing, 2nd Floor, St. Mary's Hospital, London W2 1NY, UK.
Tibolone is used for hormone replacement therapy and acts in a tissue-specific manner being oestrogenic on CNS and bone but not on breast tissues or endometrium. The ability of tibolone and its metabolites to inhibit steroid sulphatase (STS) activity has a crucial role in regulating its tissue-specific effects. In this study, we have examined the ability of tibolone and its non-sulphated and sulphated metabolites to inhibit STS activity in different enzyme preparations and in intact cells.
View Article and Find Full Text PDFDiabetologia
July 2004
Department of Endocrinology and Metabolic Medicine, Division of Medicine, Faculty of Medicine, Imperial College London, St. Mary's Hospital, Mint Wing 2nd Floor, London, W2 1PG, UK.
Aims/hypothesis: Our aim was to define the level of glycaemia at which pancreatic insulin secretion, particularly first-phase insulin release, begins to decline.
Methods: Plasma glucose and insulin concentrations were measured during an IVGTT in 553 men with non-diabetic fasting plasma glucose concentrations. In 466 of the men C-peptide was also estimated.
BJOG
May 2004
Department of Obstetrics and Gynaecology, Mint Wing, St Mary's Hospital, Imperial College, London, UK.
Objective: To assess whether method of administration of a standard urinary symptom questionnaire alters the relationship of symptoms with urodynamic diagnoses.
Design: Randomised crossover study.
Setting: Tertiary Urogynaecology Unit, London, UK.
Hum Reprod
December 2003
Faculty of Medicine, Department of Obstetrics and Gynaecology, Imperial College London, St Mary's Hospital, Mint Wing, South Wharf Road, London W2 1PG, UK.
Background: Some cases of recurrent miscarriage have a thrombotic basis. Thromboelastography is a rapid, reproducible test of whole-blood haemostasis.
Methods: Thromboelastography was performed in 494 consecutive, non-pregnant women (median age 35 years; range 21-48) with a history of miscarriages at <12 weeks gestation (median 4; range 3-12) and 55 parous women (median age 33 years; range 20-41) with no history of pregnancy loss.
Maturitas
October 2003
Endocrinology and Metabolic Medicine, Faculty of Medicine, Imperial College London, Mint Wing, St. Mary's Hospital, Praed Street, London W2 1NY, UK.
Hum Reprod
April 2002
Department of Reproductive Medicine and Science, Imperial College, St Mary's Hospital, Mint Wing, Praed Street, London W2 1PG, UK.
Background: Polycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder affecting women of reproductive age. The syndrome is characterized by a combination of polycystic ovarian morphology, clinical features and biochemical indices. The objective of this prospective observational study was to investigate the relationship between the total ovarian volume and the ovarian stromal volume, measured using a three-dimensional (3D) ultrasound scan, with biochemical indices of PCOS.
View Article and Find Full Text PDFGynecol Endocrinol
October 2001
Department of Reproductive Medicine and Science, Imperial College School of Medicine, St Mary's Hospital, Norfolk Place, Mint Wing, London W2 1PG, UK.
Polycystic ovary syndrome (PCOS) is a convergence of multisystem endocrine derangements. Impairment in insulin metabolism is a prominent feature of the syndrome and appears to play a key pathogenetic role precipitating the cascade of other disorders associated with PCOS. Recent studies report that insulin-sensitizing agents, such as metformin, reduce hyperinsulinemia, reverse the endocrinopathy of PCOS and normalize endocrine, metabolic and reproductive functions, leading to the resumption of menstrual cyclicity and ovulation.
View Article and Find Full Text PDFJ R Soc Med
October 2001
Department of Endocrinology and Metabolic Medicine, Imperial College School of Medicine, Mint Wing, St Mary's Hospital, Praed Street, London W2 1NY, UK.
Hum Reprod
September 2001
Department of Reproductive Science and Medicine, Imperial College School of Medicine at St Mary's Hospital, Mint Wing, South Wharf Road, London W2 INY, UK.
Background: This study examines the effect of intrauterine haematomas (IUH) discovered during early pregnancy ultrasound scanning in patients with recurrent miscarriage. Previous studies of IUHs have reported conflicting findings, and none studied women with recurrent miscarriage.
Methods: A total of 341 women with a viable pregnancy was included.
QJM
April 2001
Renal Unit, Mint Wing, St Mary's Hospital, Praed Street, London W2 1NY, UK.
There is a high incidence of end-stage renal failure (ESRF) of undetermined cause in the Indo-Asian population of the UK. We studied patients presenting from the district of Brent and Harrow, which has a large Indo-Asian community, and whose renal services are largely provided by our centre. The diagnosis and ethnicity of patients starting renal replacement therapy and/or undergoing renal biopsy were collated.
View Article and Find Full Text PDFJ Steroid Biochem Mol Biol
November 2000
Endocrinology and Metabolic Medicine, Imperial College School of Medicine, Mint Wing, St Mary's Hospital, Praed Street, W2 1NY, London, UK.
Hum Reprod
November 2000
Section of Endocrinology and Metabolic Medicine (The Mint Wing), ICSM at St Mary's, Department of Pathology, St Mary's Hospital, Paddington, London, W2 1NY, UK.
The obstetric risks of adverse outcome during pregnancy in women aged > or =35 years were quantified using a retrospective analysis of data from 385 120 singleton pregnancies in the North West Thames Region, UK, between 1988 and 1997. A comparison of pregnancy outcome was made on the basis of maternal age at delivery: 18-34 years (n = 336 462), 35-40 years (n = 41 327) and women aged > 40 years (n = 7331). Women aged <18 years (n = 5246) were excluded from the study.
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