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Phase 3 Trial of Stereotactic Body Radiotherapy in Localized Prostate Cancer.

N Engl J Med

October 2024

From the Royal Marsden Hospital (N.A., A.T., O.N.), the Institute of Cancer Research (N.A., C.G., A.T., J. Patel, E.W., J. Pugh, G.M., S. Brown, S. Burnett, E.H.), St. Bartholomew's Hospital (P.W.), and Patient and Public Representative (D.P.), London, the Mount Vernon Cancer Centre, Northwood (P.O.), the James Cook University Hospital, Middlesbrough (H.V.), University Hospitals Birmingham, Birmingham (D.F.), the Clatterbridge Cancer Centre, Birkenhead (S.T.), Queen's University Belfast, Belfast (S.J.), Churchill Hospital, Oxford (P.C.), University Hospitals of Leicester, Leicester (K.K.), Freeman Hospital, Newcastle (J.F.), University Hospitals Coventry and Warwickshire, Coventry (A.C.), Velindre Cancer Centre, Cardiff (J.S.), and Cambridge University Hospitals NHS Foundation Trust, Cambridge (A.M.) - all in the United Kingdom; Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto (A.L., W.C.), and the Department of Oncology, McMaster University, Hamilton, ON (I.D.) - both in Canada; and Cancer Trials Ireland and St. Luke's Radiation Oncology Network, St. Luke's Hospital - both in Dublin (J.A.).

Article Synopsis
  • A study investigated whether stereotactic body radiotherapy (SBRT) is just as effective as standard radiotherapy for treating localized prostate cancer in terms of treatment failure rates.
  • The trial involved 874 men with early-stage prostate cancer, comparing SBRT (36.25 Gy in 5 sessions) to conventional radiotherapy (78 Gy in 39 sessions or 62 Gy in 20 sessions) over several weeks, focusing on the chance of being free from cancer progression after 5 years.
  • Results showed that SBRT was noninferior to standard treatment, with similar success rates in preventing cancer failure (95.8% for SBRT vs. 94.6% for control) but higher rates of genitour
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