34 results match your criteria: "St. Luke's Cancer Institute[Affiliation]"

Article Synopsis
  • The study aimed to assess if adding the PARP inhibitor talazoparib to the immune checkpoint inhibitor atezolizumab could enhance outcomes for patients with SLFN11-positive extensive stage small cell lung cancer (ES-SCLC) after initial treatment.
  • A total of 106 patients were randomized into two groups, showing that the combination therapy (talazoparib plus atezolizumab) led to improved progression-free survival compared to atezolizumab alone, though overall survival rates remained similar between the two groups.
  • While the combination therapy improved progression-free survival, it also resulted in higher rates of severe hematological side effects, such as grade 3 anemia, highlighting the need for careful patient selection based on genetic markers
View Article and Find Full Text PDF

Combination strategies in advanced hepatocellular carcinoma: the CARES-310 trial.

Lancet

October 2024

Department of Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA; Department of Hematology/Oncology, St Luke's Cancer Institute, Kansas City, MO 64111, USA. Electronic address:

View Article and Find Full Text PDF
Article Synopsis
  • Dual inhibition using ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) was tested on patients with desmoid tumors in a phase II clinical trial to assess efficacy and safety in treating these rare solid tumors.
  • The study involved 16 patients, with an overall response rate (ORR) of 18.8%, and a clinical benefit rate (CBR) of 62.5%, indicating decent stability and response to treatment over an average of 19.4 months of progression-free survival (PFS).
  • Adverse events were common, with fatigue, nausea, and hypothyroidism reported, highlighting the need for careful monitoring during treatment.
View Article and Find Full Text PDF

Burnout and its negative sequelae are a persistent problem in gynecologic oncology, threatening the health of our physician workforce. Individual-level interventions such as stress management training, physical activity, and sleep hygiene only partially address this widespread, systemic crisis rooted in the extended work hours and stressful situations associated with gynecologic oncology practice. There is an urgent need for systematic, institution-level changes to allow gynecologic oncologists to continue the crucial work of caring for people with gynecologic cancer.

View Article and Find Full Text PDF

Immune-related adverse events (irAEs) are the most common complication of immune checkpoint inhibitor (ICI) therapy. With the widespread use of ICIs in patients with solid tumors, up to 40% of the patients develop irAEs within five months of treatment, and 11% develop severe irAEs requiring interventions. A predictive test for irAEs would be a crucial tool for monitoring for complications during and after ICI therapy.

View Article and Find Full Text PDF

Background: Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic profiling of tumor samples with a molecular tumor board (MTB) approach to make real‑time treatment decisions for children with relapsed/refractory solid tumors.

Methods: Subjects were divided into three strata: stratum 1-relapsed/refractory neuroblastoma; stratum 2-relapsed/refractory CNS tumors; and stratum 3-relapsed/refractory rare solid tumors.

View Article and Find Full Text PDF

Purpose: This paper reports the efficacy of the poly (ADP-ribose) polymerase inhibitor olaparib alone and in combination with the antiangiogenesis agent cediranib compared with cediranib alone in patients with advanced endometrial cancer.

Methods: This was open-label, randomized, phase 2 trial (NCT03660826). Eligible patients had recurrent endometrial cancer, received at least one (<3) prior lines of chemotherapy, and were Eastern Cooperative Oncology Group performance status 0 to 2.

View Article and Find Full Text PDF

Background: Although common in lung cancer, somatic epidermal growth factor receptor () mutations are rarely found in colorectal cancer, occurring in approximately 3% of cases. Treatment with anti-EGFR antibodies is commonplace, but tyrosine kinase inhibitors are not standard treatments in colorectal cancer. Here we report a case of sustained response to osimertinib in a colorectal cancer patient with an T790M mutation on cell-free DNA analysis.

View Article and Find Full Text PDF

Sequencing Systemic Therapy in Hepatocellular Carcinoma.

Curr Treat Options Oncol

November 2023

Department of Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.

Multiple treatment options are now approved for unresectable hepatocellular carcinoma (HCC). An immune checkpoint inhibitor (ICI)-containing regimen should be highly considered as the first-line treatment when there is no contraindication, especially in those with hepatitis virus-related HCC, due to proven superior overall survival (OS) compared to sorafenib. Atezolizumab plus bevacizumab and durvalumab plus tremelimumab remain the treatment of choice among all ICI-containing regimens, unless contraindications to either of the medications exist.

View Article and Find Full Text PDF

Purpose: Increased awareness of the distinct tumor biology for adolescents and young adults (AYAs) with cancer has led to improvement in outcomes for this population. However, in cholangiocarcinoma (CCA), a paucity of data exist on the AYA population. To our knowledge, we present the largest study to date on AYA disease biology, treatment patterns, and survival outcomes in CCA.

View Article and Find Full Text PDF

Background: Treatment patterns for intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) differ, but limited studies exist comparing them. This study examines differences in molecular profiling rates and treatment patterns in these populations, focusing on use of adjuvant, liver-directed, targeted, and investigational therapies.

Methods: This multicenter collaboration included patients with ICC or ECC treated at 1 of 8 participating institutions.

View Article and Find Full Text PDF

We defined orienting language in genetic counseling sessions as 'language intended to direct focus to a particular aspect of the counseling process; a physical, emotional, or cognitive space; or an outcome'. This is a concept expanding on the idea of 'orientation' statements in the genetic counseling literature. We propose that orienting language is an important component of effective communication in the genetic counseling process.

View Article and Find Full Text PDF

SGO and the elephant that is still in the room: Wellness, burnout and gynecologic oncology.

Gynecol Oncol

November 2022

Division of Gynecologic Oncology, University of Wisconsin, Madison, WI, United States of America.

Objective: To measure wellness and burnout among gynecologic oncology clinicians and identify trends and at-risk populations to inform future interventions.

Methods: Gynecologic oncologist (GO) and advanced practice provider (APP) responses to the 2020 Society of Gynecologic Oncology State of the Society survey were analyzed. The Maslach Burnout Inventory criteria for burnout was used.

View Article and Find Full Text PDF

Purpose: To describe the creation of a statewide leadership training program for practicing pharmacists and pharmacy technicians. The 2 overarching goals were to (1) enable learners to develop foundational leadership skills that could be used at their place of work or would enable them to take on a new or advanced role and (2) help foster sustainability within our state pharmacy society through incorporation of the learners on committees and projects, bringing awareness to board member roles and functions. Overall, the program's mission was to empower practicing pharmacists and pharmacy technicians to take on leadership roles within their organization and the state pharmacy society.

View Article and Find Full Text PDF

Background: Pain and nausea affect a significant number of patients with cancer. Applying foot reflexology to this population has had some positive effects, but more studies are needed to confirm its efficacy.

Objectives: The purpose of this study was to conduct a randomized controlled trial to evaluate the effects of foot reflexology on pain and nausea among inpatients with cancer as compared to traditional nursing care alone.

View Article and Find Full Text PDF

Current Updates on the Management of AL Amyloidosis.

J Hematol

August 2021

St Luke's Cancer Institute, University of Missouri Kansas City, 4321 Washington St, Ste 4000, Kansas City, MO 64111, USA.

Article Synopsis
  • Systemic immunoglobulin light chain (AL) amyloidosis is a rare and deadly disease caused by the overproduction of misfolded proteins by plasma cells, leading to damage in various organs.
  • Historically, treatments for AL amyloidosis were adapted from those used for multiple myeloma, its more common relative.
  • Recent research has focused on enhancing treatment strategies and updating clinical guidelines as the prevalence of AL amyloidosis rises.
View Article and Find Full Text PDF

Background: Acute myeloid leukemia (AML) is fatal in elderly patients who are unfit for standard induction chemotherapy. The objective of this study was to evaluate the survival benefit of administering sapacitabine, an oral nucleoside analogue, in alternating cycles with decitabine, a low-intensity therapy, to elderly patients with newly diagnosed AML.

Methods: This randomized, open-label, phase 3 study (SEAMLESS) was conducted at 87 sites in 11 countries.

View Article and Find Full Text PDF

Non-secretory multiple myeloma (NSMM) constitutes a distinct entity of multiple myeloma characterized by the absence of detectable monoclonal protein and rarely an absence of free light chains in the serum and urine. Given its rarity, the genomic landscape, clinical course, and prognosis of NSSM are not well characterized. Here, we report a case of a patient with relapsed and refractory NSMM with brain metastasis harboring a TFG-ALK fusion showing a dramatic and durable (over two years) response to commercially available anaplastic lymphoma kinase (ALK) inhibitors.

View Article and Find Full Text PDF

Multivariate risk models are commonly used in clinical practice to estimate a woman's lifetime risk for breast cancer and assist in implementation of appropriate screening and risk reduction strategies. More recently, breast cancer polygenic risk scores (PRS) have been derived and integrated into these models to further improve risk estimation. While breast cancer PRS have been offered by two clinical diagnostic laboratories since 2017, little is known about the extent to which genetic counselors are ordering breast cancer PRS or incorporating the results into patient management.

View Article and Find Full Text PDF

Bioinspired tailoring of fluorogenic thiol responsive antioxidant precursors to protect cells against HO-induced DNA damage.

Free Radic Biol Med

November 2020

Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, Ioannina, 45110, Greece; University Research Center of Ioannina (URCI), Institute of Materials Science and Computing, Ioannina, Greece. Electronic address:

Natural antioxidants, like phenolic acids, possess a unique chemical space that can protect cellular components from oxidative stress. However, their polar carboxylic acid chemotype reduces full intracellular antioxidant potential due to limited diffusion through biological membranes. Here, we have designed and developed a new generation of hydrophobic turn-on fluorescent antioxidant precursors that upon penetration of the cell membrane, reveal a more polar and more potent antioxidant core and simultaneously become fluorescent allowing their intracellular tracking.

View Article and Find Full Text PDF