7 results match your criteria: "St. Louis (R.S.); and the University of Michigan Law School[Affiliation]"
Phenoconversion in Women and Men With Isolated REM Sleep Behavior Disorder: A Retrospective Cohort Study.
Neurology
November 2024
From the Mayo Center for Sleep Medicine (C.A.A., S.J.M., G.M.T., L.L.-V., J.C.F., T.R.G., E.P.S., J.T.J., M.R.K., T.F., E.J.O., D.J.S., T.J.M., M.J., M.L., J.L.M., M.T.-P., D.Z.C., M.H.S., E.K.S.L.), Department of Neurology; Mayo Center for Sleep Medicine (S.J.M., G.M.T., L.L.-V., J.C.F., T.R.G., E.P.S., J.T.J., M.R.K., T.F., D.J.S., T.J.M., M.J., M.L., J.L.M., M.T.-P., D.Z.C., M.H.S., E.K.S.L.),; Department of Neurology (F.A., H.B., J.G.-R., R.S., W.S., B.F.B.); Department of Radiology (K.K.); Department of Cardiovascular Medicine (N.C., V.K.S.); Department of Medicine (J.L.K.); and Mayo Center for Sleep Medicine (C.A.M.), Department of Pediatrics, Mayo Clinic.
Article Synopsis
- - The study investigates isolated REM sleep behavior disorder (iRBD) and its links to neurodegenerative diseases, focusing on gender differences and younger adults, which are less explored compared to older males.
- - Researchers followed 372 participants (186 women and 186 men with iRBD), finding that women were diagnosed at a younger age than men and that over 12% converted to a neurodegenerative disorder within roughly 6 years.
- - Key findings indicate that older age at diagnosis is a significant factor for phenoconversion risk, with lower risk observed in those using antidepressants or having chronic pain, while higher risk was noted in individuals with vascular issues.
Validation of the RBD Symptom Severity Scale in the North American Prodromal Synucleinopathy Consortium.
Neurology
February 2024
From the Cleo Roberts Memory and Movement Clinic (D.S., P.C.), Banner Sun Health Research Institute, Sun City; Division of Neurology (J.K.L.-I.) and Division of Neurology, Sleep Disorders Center (P.R.), Banner University Medical Center, Phoenix; College of Medicine (A.O.B.), University of Arizona, Tucson; Neurophysiology Unit (M.L.F.), Neurology Department, Clermont-Ferrand University Hospital, Institut Pascal, CNRS, Université Clermont Auvergne, France; Department of Neurology (A.Y.A.), University of California Los Angeles; Department of Neurology (D.L.B., D.E.H.), Emory University School of Medicine, Atlanta, GA; Department of Neurology (S.R.C., J.M., Y.-E.S.J.), Washington University School of Medicine, St. Louis, MO; Department of Neurology (E.H.D., M.G.M.), Stanford University; Department of Neurology (J.E.E., M.M.L.), VA Portland Health Care System and Oregon Health & Science University; Department of Psychiatry and Psychology (J.A.F.), Mayo Clinic, Rochester, MN; Department of Psychology (J.-F.G.), Université du Québec à Montréal, Canada; Department of Neurology (M.J.H., C.H.S.), University of Minnesota Medical Center, Minneapolis; Center of Sleep Sciences (E.M.), Stanford University, CA; Research Institute of the McGill University Health Centre (A.P.), Montréal; Center for Advanced Research in Sleep Medicine (A.P.), Hôpital du Sacré-Coeur de Montréal, Québec, Canada; Department of Neurology (E.K.S.L., B.F.B.), Mayo Clinic, Rochester, NY; Department of Neurology (A.V.), Harvard Medical School, Boston, MA; and Department of Neurology (R.P.), McGill University, Montréal, Canada.
Background And Objectives: REM sleep behavior disorder (RBD) is a parasomnia characterized by dream enactment. The International RBD Study Group developed the RBD Symptom Severity Scale (RBDSSS) to assess symptom severity for clinical or research use. We assessed the psychometric and clinimetric properties of the RBDSSS in participants enrolled in the North American Prodromal Synucleinopathy (NAPS) Consortium for RBD.
View Article and Find Full Text PDFAutonomic dysregulation during sleep in Parkinsonian spectrum disorders - A proof of concept.
Parkinsonism Relat Disord
December 2023
Departments of Neurology and Medicine and Center for Sleep Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Introduction: Autonomic dysfunction is common in α-synucleinopathies such as Lewy Body dementias (LBD), Parkinson's disease (PD), and isolated REM Sleep Behavior Disorder (iRBD). We analyzed pulse-rate changes during sleep to index autonomic nervous system (ANS) dysfunction in patients with α-synucleinopathies vs. non-synucleinopathy groups expected to have normal ANS function.
View Article and Find Full Text PDFβ-Amyloid Load on PET Along the Continuum of Dementia With Lewy Bodies.
Neurology
July 2023
From the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Background And Objectives: β-Amyloid (Aβ) plaques can co-occur with Lewy-related pathology in patients with dementia with Lewy bodies (DLB), but Aβ load at prodromal stages of DLB still needs to be elucidated. We investigated Aβ load on PET throughout the DLB continuum, from an early prodromal stage of isolated REM sleep behavior disorder (iRBD) to a stage of mild cognitive impairment with Lewy bodies (MCI-LB), and finally DLB.
Methods: We performed a cross-sectional study in patients with a diagnosis of iRBD, MCI-LB, or DLB from the Mayo Clinic Alzheimer Disease Research Center.
Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis.
Circ Res
July 2022
Dianne Nunnally Hoppes Laboratory (K.P., Q.L., H.Y., E.M., T.S., R.S.L., Q.L., S.K., J.F., H.P., I.-H.W., M.G.Y., H.S., G.L.K.), Harvard Medical School, Boston, MA.
Background: Insulin resistance (IR) can increase atherosclerotic and cardiovascular risk by inducing endothelial dysfunction, decreasing nitric oxide (NO) production, and accelerating arterial inflammation. The aim is to determine the mechanism by which insulin action and NO production in endothelial cells can improve systemic bioenergetics and decrease atherosclerosis via differentiation of perivascular progenitor cells (PPCs) into brown adipocytes (BAT).
Methods: Studies used various endothelial transgenic and deletion mutant mice of insulin receptors, eNOS (endothelial NO synthase) and ETBR (endothelin receptor type B) receptors for assessments of atherosclerosis.
Background: The Hemophilia Joint Health Score (HJHS) was developed and validated to detect arthropathy in children. Additional evidence is required to show validity in adults. We studied the convergent and discriminant construct validity of the HJHS version 2.
View Article and Find Full Text PDFREM sleep atonia loss distinguishes synucleinopathy in older adults with cognitive impairment.
Neurology
January 2020
From the Mayo Center for Sleep Medicine (S.J.M., G.M.T., D.J.S., P.C.T., K.L.J., A.R.M., R.S., M.M.M., B.F.B., M.H.B., E.K.S.L.) and Departments of Neurology (S.J.M., P.V., B.F.B., M.H.S., E.K.S.L.), Health Science Research (R.S., M.M.M.), Psychology (M.M.M.), Radiology (K.K.), and Medicine (E.K.S.L.), Mayo Clinic and Foundation, Rochester, MN; Department of Neurology (H.-Y.J.), Providence Neurological Specialties-West, Portland, OR; and University of Minnesota Duluth (A.R.M.).
Objective: To determine whether quantitative polysomnographic REM sleep without atonia (RSWA) distinguishes between cognitive impairment phenotypes.
Background: Neurodegenerative cognitive impairment in older adults predominantly correlates with tauopathy or synucleinopathy. Accurate antemortem phenotypic diagnosis has important prognostic and treatment implications; additional clinical tools might distinguish between dementia syndromes.