Making the Cut: A Six-Year "Bone-afide" Membership Trend From Student to Surgeon.

Background: Mentorship and early exposure vary greatly from school to school for osteopathic medical students. Historically, allopathic medical students have matched at a higher rate for competitive surgical specialties, like orthopedic surgery, compared to osteopathic medical students. The unique position of medical student interest organizations in filling those gaps and their related outcomes, including successful residency acceptance, is unknown.

Case report: hibernoma, a rare male breast mass.

Hibernomas are rare, benign neoplasms characterized by the presence of brown adipose tissue. Although these tumors may arise in any region of brown fat, they predominantly occur in the thigh, shoulder, back, and neck. Hibernomas are rarely found in mammary tissue, with a higher prevalence in females than males.

Underappreciated Relationship: A Case of Type A Aortic Dissection Presented With Atrial Flutter.

Aortic dissection (AD) is a life-threatening emergency involving a tear in the aortic intima, leading to a false lumen. Atrial fibrillation (AF) can complicate AD, increasing management challenges and mortality risks. We report a 67-year-old male with no known past medical history who presented with a 1-day history of abdominal pain.

ortholog of the Muller D element .

The feature with Gene ID 108083276 was determined to be an ortholog of absent, small, or homeotic discs 1 ( ). Two isoforms, ash1-PB and ash1-PC, were constructed on the Muller D element using the GEP annotation protocol. The second coding exon of includes an insertion translated into 18 additional amino acids compared to the protein and is supported by RNA-Seq coverage, the lack of splice junction predictions, and multiple gene predictors.

A new species of Paraputo Laing 1929 (Hemiptera: Coccomorpha: Pseudococcidae) from India.

A new mealybug species, Paraputo blackmani Joshi, sp. n. (Hemiptera: Coccomorpha: Pseudococcidae) is described and illustrated based on adult females collected from Butea monosperma (Fabaceae), in Bengaluru Rural district, Karnataka, southern India.

Formulation development of dual-compartment topical inserts combining tenofovir alafenamide and elvitegravir for flexible on-demand HIV prevention.

Pre-exposure prophylaxis (PrEP) has emerged as a prominent approach for the prevention of HIV infections. While the latest advances have resulted in effective oral and injectable product options, there are still gaps in on-demand, event-driven, topical products for HIV prevention that are safe and effective. Here we describe the formulation development of a dual-compartment topical insert containing tenofovir alafenamide fumarate (TAF) and elvitegravir (EVG) that may be administered when needed, vaginally or rectally, pre- or post-coitus, for flexible HIV prophylaxis.

Modification of the modified Graham patch repair for duodenal perforation using the gastrocolic ligament: Two case reports.

Introduction: Gastroduodenal perforations are relatively common surgical emergencies with mortality rates as high as 40%. The Graham patch repair is one surgical approach but may need to be modified when the patient lacks viable omentum. The gastrocolic ligament can be utilized to repair these perforations for coverage.

Through their eyes: Empathetic learning for frontline healthcare providers to improve care for the patient living with dementia.

Evoking emphatic care and committing to an elder-friendly environment for older adults living with dementia is a focus at many Nurses Improving Care for Healthsystem Elders (NICHE) member organizations. Improved dementia knowledge and skills for treating older adults optimize clinical outcomes and patient and family satisfaction. The dementia protocol utilized in NICHE organizations recommends providing a safe therapeutic environment and caregiver education and support.

Evolutionary Analysis of the hnRNP Interactomes and Their Functions in Eukaryotes.

The heterogeneous nuclear ribonucleoproteins (hnRNPs) are central regulators of several fundamental biological processes across eukaryotes. hnRNPs have been implicated in transcriptional and post-transcriptional regulation, telomere maintenance, stem cell maintenance, among other processes in major model organisms. Though hnRNPs are known to be conserved in eukaryotes, the evolutionary conservation/diversification of their functions across species is yet to be understood.

Novelty in the gut: a review of the gastrointestinal manifestations of syphilis.

Syphilis is a systemic infection caused by the spirochete . It is transmitted during pregnancy or through sexual contact. Signs and symptoms vary depending on the clinical stage of the disease.

Towards the clinical translation of a silver sulfide nanoparticle contrast agent: large scale production with a highly parallelized microfluidic chip.

Purpose: Ultrasmall silver sulfide nanoparticles (AgS-NP) have been identified as promising contrast agents for a number of modalities and in particular for dual-energy mammography. These AgS-NP have demonstrated marked advantages over clinically available agents with the ability to generate higher contrast with high biocompatibility. However, current synthesis methods for inorganic nanoparticles are low-throughput and highly time-intensive, limiting the possibility of large animal studies or eventual clinical use of this potential imaging agent.

Inferior Clinical Outcomes Following Endoscopic Proximal Hamstring Repair in Patients With Chronic Degenerative Tears Despite the Use of Dermal Allograft Augmentation.

Purpose: To compare clinical outcomes in patients undergoing endoscopic proximal hamstring repair with and without dermal allograft augmentation.

Methods: A retrospective review of prospectively collected data was performed on patients undergoing endoscopic proximal hamstring repair (PHR) and proximal hamstring repair with dermal allograft augmentation (PHR-A) by a single surgeon between 2016 and 2023. Augmentation was utilized for cases of chronic degenerative tears (≥6 weeks from the time of initial injury) where hamstring tissue quality was deemed poor intraoperatively.

The Ashkenazi-Centric G334R Variant of is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model.

Mutations in the tumor suppressor gene are the most abundant genetic occurrences in cancer. Some of these mutations lead to loss of function of p53 protein, some are gain of function, and some variants are hypomorphic (partially functional). Currently, there is no clinical distinction between different p53 mutations and cancer therapy or prognosis.

Rectal Adenocarcinoma With Pagetoid Spread: A Novel Entity.

Perianal Paget's disease (PPD) is a rare skin adenocarcinoma that arises in the apocrine glands of the perianal region. It is often misdiagnosed as eczema, leukoplakia, squamous cell carcinoma, Bowen's disease, lichen planus, or condylomata acuminata. We report a case of a 63-year-old male who presented to the emergency room (ER) for evaluation of an anal mass that had persisted over 6 months.

Surgical treatment of coexisting intra and extralobar sequestration in an infant.

Pulmonary sequestration is a rare congenital malformation in which a nonfunctional segment of lung tissue has no communication with the tracheobronchial tree and does not participate in gas exchange. We present a rare case of a 20-month old female with extralobar pulmonary sequestration that was diagnosed at birth. The patient was also found to have a coexisting intralobar sequestration, found during surgery.

Pulmonary Kaposi Sarcoma in the Era of Antiretroviral Therapy: A Case Series.

Kaposi sarcoma (KS) is an angioproliferative neoplasm that affects the skin and lymph nodes. Human herpesvirus-8 (HHV-8) triggers KS by infecting the endothelium and inducing angiogenesis through the production of vascular endothelial growth factors and cytokines. KS is characterized by purplish or hyperpigmented plaques involving the skin and mucous membranes, and visceral involvement is very rare.

Symptomatic Valvular and Subvalvular Stenosis: A Case Report.

Aortic stenosis is a common valvular disease that is expected to become more prevalent with the aging population. It is often undiagnosed in socioeconomically deprived groups. Diagnosis relies on echocardiography, and additional imaging techniques such as cardiac computed tomography (CCT) and cardiovascular magnetic resonance (CMR) are increasingly used.