1 results match your criteria: "St. Joseph's Healthcare Hamilton and the Henderson Research Centre[Affiliation]"
The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response.
J Lipid Res
December 2009
Department of Medicine, McMaster University, St. Joseph's Healthcare Hamilton and the Henderson Research Centre, Hamilton, Ontario, L8N 4A6, Canada.
Recent studies have shown a link between obesity and endoplasmic reticulum (ER) stress. Perturbations in ER homeostasis cause ER stress and activation of the unfolded protein response (UPR). Adipocyte differentiation contributes to weight gain, and we have shown that markers of ER stress/UPR activation, including GRP78, phospho-eIF2, and spliced XBP1, are upregulated during adipogenesis.
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