6 results match your criteria: "St. Joseph's Health Centre (Unity Health Toronto)[Affiliation]"
Whole-of-Life Inclusion in Bayesian Adaptive Platform Clinical Trials.
JAMA Pediatr
October 2024
Department of Infectious Diseases, Perth Children's Hospital, Perth, Western Australia, Australia.
Article Synopsis
- There is a significant need for clinical trials that include infants, children, and adolescents to ensure evidence-based care; this communication discusses three different trial design strategies to address this issue.
- The three strategies include sequential, parallel, and unified adult-pediatric Bayesian adaptive designs, which allow for better integration of pediatric populations into clinical research.
- The unified design, exemplified by the SNAP trial, utilizes Bayesian hierarchical models to share data across age groups, enhancing accuracy in assessing treatment safety and efficacy for both children and adults.
Association between surgeon volume and the use of laparoscopic liver resection: retrospective cohort study.
BJS Open
July 2024
Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Regional and national antimicrobial stewardship activities: a survey from the Joint Programming Initiative on Antimicrobial Resistance-Primary Care Antibiotic Audit and Feedback Network (JPIAMR-PAAN).
JAC Antimicrob Resist
April 2023
Health Protection, Public Health Ontario, Toronto, Canada.
Background: Antibiotic overuse and misuse in primary care are common, highlighting the importance of antimicrobial stewardship (AMS) efforts in this setting. Audit and feedback (A&F) interventions can improve professional practice and performance in some settings.
Objectives And Methods: To leverage the expertise from international members of the Joint Programming Initiative on Antimicrobial Resistance - Primary care Antibiotic Audit and feedback Network (JPIAMR-PAAN).
Tranexamic acid versus placebo to reduce perioperative blood transfusion in patients undergoing liver resection: protocol for the haemorrhage during liver resection tranexamic acid (HeLiX) randomised controlled trial.
BMJ Open
February 2022
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Article Synopsis
- A study is looking at how to reduce blood transfusions needed during liver surgery because many patients still need them after surgery, which can be risky.
- Researchers will test a drug called tranexamic acid (TXA) on 1230 people to see if it can help lower blood loss during surgery and reduce the need for transfusions.
- The study is approved by health authorities, and results will be shared to help others learn from the findings.
The inferior boundary of dissection as a novel landmark for safe laparoscopic cholecystectomy.
HPB (Oxford)
July 2021
HPB Surgery Service, Division of General Surgery, St. Joseph's Health Centre - Unity Health Toronto, 30 The Queensway, Toronto, ON, M6R1B5, Canada; Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Canada. Electronic address:
Background: Since the introduction of laparoscopic cholecystectomy over 30 years ago, rates of bile duct injury have remained elevated compared to the era of open cholecystectomy. We propose an anatomical landmark, the Inferior Boundary of Dissection, to help prevent dangerous dissection in the porta hepatis and provide clues as to when a critical view of safety may not be immediately achieved.
Methods: This landmarking approach is based on fundamentals of biliary anatomy and surface landmarks of the liver.
The Case against Vitamin D Supplementation in Healthy Adults.
J Appl Lab Med
June 2020
Department of Laboratory Medicine, St. Joseph's Health Centre (Unity Health Toronto), Toronto, ON, Canada.