Indolyl-4H-Chromene Derivatives as Antibacterial Agents: Synthesis, in Vitro and in Silico Studies.

In this study, indolyl-4H-chromene derivatives are designed and synthesised using an eco-friendly multicomponent one-pot synthesis using benzaldehydes, nitroketene N, S-acetals, and indoles combine with InCl , a Lewis acid catalyst, and ethanol, an environmentally acceptable solvent. Due to antibiotic resistance, assessed these Indolyl-4H-chromene derivatives for their in vitro antibacterial activity against Gram-positive and Gram-negative bacteria, including Streptococcus pyogenes, Staphylococcus aureus, Clostridium pyrogenes, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa, using the agar well diffusion method and Minimum Inhibition Concentration (MIC) assay. Three compounds, 4-(1H-indol-3-yl)-6-methoxy-N-methyl-3-nitro-4H-chromen-2-amine, 4-(1H-indol-3-yl)-3-nitro-N-phenyl-4H-chromen-2-amine and 4-(6-Fluoro-1H-Indol-3-yl)-N-methyl-3-nitro-4H-chromen-2-amine showed better zone of inhibition (mm) and Minimum Inhibition Concentration (MIC) values of 10 μg/mL to 25 μg/mL against all bacterial types.

Microplastics - A major contaminant in marine macro algal population: Review.

Microplastics (MPs) are a significant concern in this modern environment, and the marine environment is a sink for them now. Researchers have taken an interest in marine microplastic studies recently, which has opened the door to research in macroalgae and microalgae. Macroalgae are the primary producers in maritime ecosystems and are economically significant.

Antimicrobial activity prediction, inter- and intramolecular charge transfer investigation, reactivity analysis and molecular docking studies of adenine derivatives.

The utilization of the density functional theory (DFT) methodology has developed as a highly efficient method for investigating molecular structure and vibrational spectra, and it is increasingly being employed in various applications relating to biological systems. This study focuses on conducting investigations, both experimental and computed, to analyze the molecular structure, electronic properties and features of (E)-4-(((9H-purin-6-yl)imino)methyl)-2-methoxyphenol (ANVA). The expression ANVA should be rewritten as follows: the compound is a derivative of adenine (primary amine), specifically a vanillin (aldehyde).

Phytochemical Composition and Antioxidant and Anti-Inflammatory Activities of Sasidh. & Sujanapal, an Endemic Medicinal Plant to the Western Ghats.

Ethnomedicinal plants are important sources of drug candidates, and many of these plants, especially in the Western Ghats, are underexplored. , a genus within the Fabaceae family, thrives in the biodiversity of the Western Ghats, Kerala, India, and holds significant ethnobotanical importance. However, many species remain understudied in terms of their biological efficacy, while some lack scientific validation for their traditional uses.

Checklist of Indian Harpalinae Bonelli, 1810 (Coleoptera: Carabidae).

An updated checklist of 169 species of subfamily Harpalinae known from the Indian mainland, along with details of the revisions by modern workers, literatures and distribution patterns is provided. Of them, 39 species are endemic to the Indian mainland, whereas 11 species to the Western Ghats Hotspot of Biodiversity, one to the Indo-Burma Hotspot of Biodiversity and eight to the Himalaya Hotspot of Biodiversity. Four genera, Allosiopelus Ito, 1995, Indocarterus Kataev & Wrase, 2018, Oesyperus Andrewes, 1923 and Panagrius Andrewes, 1933 are endemic to the Indian mainland.

A new species of the genus Clypeuspinus Balkenohl, 2021 (Coleoptera: Carabidae: Scaritinae) from India.

The description of a new carabid species from Indian mainland belonging to the genus Clypeuspinus Balkenohl, 2021 which was formerly known in Sri Lanka. Revised generic characteristics of Clypeuspinus, and a key to species are provided.

Discovery of Oxygen Induced Chemoselectivity in Pd-Catalyzed C-H Functionalization: Cross-Dehydrogenative Coupling vs C-H Amination.

We have come across a substrate namely, 5-benzoyl-pyrrolo[2,1-]isoquinoline in which three different functionalizable C-H bonds were identified that could be judiciously transformed site selectively for the generation of complex polyring fused -heterocycles. A Pd-catalyzed cross-dehydrogenative coupling of 5-benzoyl-pyrrolo[2,1-]isoquinoline afforded 8-indeno-pyrrolo[2,1-]isoquinolinone and an oxygen induced palladium catalyzed selective C-H amination in the same substrate provided a pentacene viz., 9-indolo-pyrrolo[2,1-]isoquinoline.

Fog-Based Smart Cardiovascular Disease Prediction System Powered by Modified Gated Recurrent Unit.

The ongoing fast-paced technology trend has brought forth ceaseless transformation. In this regard, cloud computing has long proven to be the paramount deliverer of services such as computing power, software, networking, storage, and databases on a pay-per-use basis. The cloud is a big proponent of the internet of things (IoT), furnishing the computation and storage requisite to address internet-of-things applications.

Modulating nanostructure morphology and mesomorphic properties using unsaturation in cardanol-azo benzenes.

Herein, we report the synthesis and self-assembly of a new class of amphiphilic azo dyes derived from a plant-based phenol, cardanol. Analysis of the self-assembly of these new azo derivatives was intriguing, and they exhibit some unique nanostructures, such as bicelles and microgel-like structures, and smectic-type thermotropic mesophases.

Synergetic effect of Leucophyllum frutescens and Ehretia microphylla dyes in enhancing the photovoltaic performance of dye-sensitized solar cells.

The use of new natural dyes derived from Leucophyllum frutescens and Ehretia microphylla as well as their combination in dye-sensitized solar cells (DSSCs) has been explored for the first time in the current work. The primary pigments that sensitize the semiconductor TiO films were found to be carotenoid, anthocyanin, and chlorophyll. Pigments from Leucophyllum frutescens and Ehretia microphylla were designated as LF and EM, and their mixture blended at volume percent of 50:50, 75:25, and 25:75 were labeled as LE1, LE2, and LE3, respectively.

Recent advances in green synthesized nanoparticles for bactericidal and wound healing applications.

Nanotechnology has become an exciting area of research in diverse fields, such as: healthcare, food, agriculture, cosmetics, paints, lubricants, fuel additives and other fields. This review is a novel effort to update the practioneers about the most current developments in the widespread use of green synthesized nanoparticles in medicine. Biosynthesis is widely preferred among different modes of nanoparticle synthesis since they do not require toxic chemical usage and they are environment-friendly.

Root Bark Extract of Vent. Inhibits Solid and Ascites Tumors and Prevents the Development of DMBA-Induced Skin Papilloma Formation.

is a traditionally used plant in Ayurvedic and folk medicines. The plant is useful for the management of gastrointestinal diseases as well as skin diseases. In the present study, we analyzed the antitumor potential of in Dalton's lymphoma ascites tumor cells (DLA) and Ehrlich ascites carcinoma (EAC)-induced solid and ascites tumors.

Chemical Composition, Antioxidant, Anti-Bacterial, and Anti-Cancer Activities of Essential Oils Extracted from Risso Peel Waste Remains after Commercial Use.

Citrus plants are widely utilized for edible purposes and medicinal utility throughout the world. However, because of the higher abundance of the antimicrobial compound D-Limonene, the peel waste cannot be disposed of by biogas production. Therefore, after the extraction of D-Limonene from the peel wastes, it can be easily disposed of.

Antioxidant, Antimicrobial, Cytotoxicity, and Larvicidal Activities of Selected Synthetic Bis-Chalcones.

Plants are known to have numerous phytochemicals and other secondary metabolites with numerous pharmacological and biological properties. Among the various compounds, polyphenols, flavonoids, anthocyanins, alkaloids, and terpenoids are the predominant ones that have been explored for their biological potential. Among these, chalcones and bis-chalcones are less explored for their biological potential under in vitro experiments, cell culture models, and animal studies.

Chemical Composition and Biological Activities of the Leaf Essential Oils of , and .

species are widely used as a food additive and also in various medicinal purposes. The plant is a rich source of essential oil and is predominantly extracted from the rhizomes. On the other hand, the leaves of the plants are usually considered as an agrowaste.

Synthesis of Nickel-Chitosan Nanoparticles for Controlling Blast Diseases in Asian Rice.

Rice blast caused by Pyricularia oryzae is one of most devastating fungal diseases in rice, reducing the annual yield of rice worldwide. As an alternative to fungicide for curbing rice blast, synthesis of nickel-chitosan nanoparticles (Ni-Ch NPs) was performed with nickel chloride and assessed its efficacy in inflating plant growth and hindrance of Pyricularia oryzae (blast pathogen). Characterization of Ni-Ch NPs from SEM, TEM, and DLS analyses showed smooth- and spherical-shaped nanoparticles in the range of 20-70 nm.

Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of (C.B. Clarke) Pamp.

Plants have been employed in therapeutic applications against various infectious and chronic diseases from ancient times. Various traditional medicines and folk systems have utilized numerous plants and plant products, which act as sources of drug candidates for modern medicine. Artemisia is a genus of the Asteraceae family with more than 500 species; however, many of these species are less explored for their biological efficacy, and several others are lacking scientific explanations for their uses.

Chelate assisted phytoextraction for effective rehabilitation of heavy metal(loid)s contaminated lands.

The contamination of lands and water by heavy toxic metal(loid)s is an environmental issue that needs serious attention as it poses a major threat to public health. The persistence of heavy metals/metalloids in the environment as well as their potentially dangerous effects on organisms underpins the need to restore the areas contaminated by heavy toxic metal(loid)s. Soil restoration can be achieved through a variety of different methods.

Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review.

Spirulina is a kind of blue-green algae (BGA) that is multicellular, filamentous, and prokaryotic. It is also known as a cyanobacterium. It is classified within the phylum known as blue-green algae.

Synthesis, crystal structure, Hirshfeld surface analysis, energy frameworks and computational studies of Schiff base derivative.

The compound (E)-ethyl 3-(2-(2,4-dinitrophenyl)hydrazono)butanoate (3) was synthesised and crystallized using ethanol as a solvent. The compound was characterized by H NMR, and single crystal X-ray diffraction. The compound crystallizes in the monoclinic crystal system with the space group 2/c.

Perfluorinated alkyl substances affect the growth, physiology and root proteome of hydroponically grown maize plants.

Poly- and perfluorinated alkyl substances (PFAS) are a group of persistent organic pollutants causing serious global concern. Plants can accumulate PFAS but their effect on plant physiology, especially at the molecular level is not very well understood. Hence, we used hydroponically-grown maize plants treated with a combination of eleven different PFAS (each at 100 μg L) to investigate their bioaccumulation and effects on the growth, physiology and their impact on the root proteome.

Risk capacity and investment priority as moderators in the relationship between big-five personality factors and investment behavior: a conditional moderated moderated-mediation model.

This paper aims to explore the relationship between big-five personality traits and investment behavior, particularly in the Indian context. Riding on the theory of planned behavior (TPB), we built a multi-layered moderated moderated-mediation model exploring the complex relationships between personality traits, investment attitude, and investment strategy. We collected data from 934 respondents from the southern part of India and analyzed using the Hayes (2018) PROCESS macros to test the hypotheses.

Phytochemicals and Nanoparticles in the Modulation of PI3K/Akt/mTOR Kinases and its Implications in the Development and Progression of Gastrointestinal Cancers: A Review of Preclinical and Clinical Evidence.

Background: Gastrointestinal cancer are the major form of cancer in developing countries, which comprises gastric cancer (GC), hepatic cancer (HCC), colorectal cancers (CRC), etc.; they account for a large number of cancer-related deaths globally. Gastrointestinal cancers generally have a multifactorial origin, where both genetic and dietary factors play prominent roles.