Synthesis and characterisation of lead-magnesium-boron nanocomposite for radiation shielding application.

There is a need for the replacement of toxic lead with nontoxic materials in radiation shielding applications. Instead of pure lead, lead mixed compounds/mixtures/alloys are considered to be less toxic and hence preferred for radiation shielding purposes. The compounds with magnesium are said to be having good magnetic and mechanical properties.

Morin hydrate downregulates inflammation-mediated nitric oxide overproduction and potentiates antioxidant mechanism against anticancer drug doxorubicin oxidative hepatorenal toxicity in rats.

Objective: Doxorubicin (DOX) is a frontline antineoplastic drug that kills cancer cells through genotoxic mechanism; however, it induces organ toxicities. This study assayed whether morin hydrate (MOH) could abrogate DOX hepatorenal toxicity in rats.

Materials And Methods: There were 4 groups of rats: Control, MOH, DOX and MOH + DOX.

Indolyl-4H-Chromene Derivatives as Antibacterial Agents: Synthesis, in Vitro and in Silico Studies.

In this study, indolyl-4H-chromene derivatives are designed and synthesised using an eco-friendly multicomponent one-pot synthesis using benzaldehydes, nitroketene N, S-acetals, and indoles combine with InCl , a Lewis acid catalyst, and ethanol, an environmentally acceptable solvent. Due to antibiotic resistance, assessed these Indolyl-4H-chromene derivatives for their in vitro antibacterial activity against Gram-positive and Gram-negative bacteria, including Streptococcus pyogenes, Staphylococcus aureus, Clostridium pyrogenes, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa, using the agar well diffusion method and Minimum Inhibition Concentration (MIC) assay. Three compounds, 4-(1H-indol-3-yl)-6-methoxy-N-methyl-3-nitro-4H-chromen-2-amine, 4-(1H-indol-3-yl)-3-nitro-N-phenyl-4H-chromen-2-amine and 4-(6-Fluoro-1H-Indol-3-yl)-N-methyl-3-nitro-4H-chromen-2-amine showed better zone of inhibition (mm) and Minimum Inhibition Concentration (MIC) values of 10 μg/mL to 25 μg/mL against all bacterial types.

Microplastics - A major contaminant in marine macro algal population: Review.

Microplastics (MPs) are a significant concern in this modern environment, and the marine environment is a sink for them now. Researchers have taken an interest in marine microplastic studies recently, which has opened the door to research in macroalgae and microalgae. Macroalgae are the primary producers in maritime ecosystems and are economically significant.

Molecular cloning, overexpression, characterization, and In silico modelling analysis of a novel GDSL autotransporter-dependent outer membrane lipase (OML) of Pseudomonas guariconensis.

The outer membrane lipase (oml) gene, encoding a novel autotransporter-dependent lipase from Pseudomonas guariconensis, was cloned and sequenced. The oml gene has an open reading frame of 1866 bp. It encodes the 621 amino acid autotransporter-dependent GDSL lipase (OML), which has the highest sequence similarity (64.

Antimicrobial activity prediction, inter- and intramolecular charge transfer investigation, reactivity analysis and molecular docking studies of adenine derivatives.

The utilization of the density functional theory (DFT) methodology has developed as a highly efficient method for investigating molecular structure and vibrational spectra, and it is increasingly being employed in various applications relating to biological systems. This study focuses on conducting investigations, both experimental and computed, to analyze the molecular structure, electronic properties and features of (E)-4-(((9H-purin-6-yl)imino)methyl)-2-methoxyphenol (ANVA). The expression ANVA should be rewritten as follows: the compound is a derivative of adenine (primary amine), specifically a vanillin (aldehyde).

Synthesis and in vitro characteristics of biogenic-derived hydroxyapatite for bone remodeling applications.

The inorganic component of bone matrix, hydroxyapatite (HAp) (with formula Ca(PO)(OH)), can be obtained from inexpensive waste resources that serve as excellent calcium precursors. In the present study, HAp nano-powder was synthesized from eggshells (ES) and crab shells (CS) by wet chemical precipitation method. Also, a hybrid sample was considered which is a mixture of HAp nano-powder synthesized from eggshells (25%) and crab shells (75%) (EC).

Cellular metabolism and health impacts of dichlorvos: Occurrence, detection, prevention, and remedial strategies-A review.

Dichlorvos (2,2-Dichlorovinyl dimethyl phosphate, [DDVP]) belongs to the class of organophosphates and is widely used as an insecticide in agriculture farming and post-harvest storage units. Extensive research has been conducted to assess the factors responsible for the presence of DDVP in terrestrial and aquatic ecosystems, as well as the entire food chain. Numerous studies have demonstrated the presence of DDVP metabolites in the food chain and their toxicity to mammals.

Evaluation of potential role of R-loop and G-quadruplex DNA in the fragility of c-MYC during chromosomal translocation associated with Burkitt's lymphoma.

t(8;14) translocation is the hallmark of Burkitt's lymphoma and results in c-MYC deregulation. During the translocation, c-MYC gene on chromosome 8 gets juxtaposed to the Ig switch regions on chromosome 14. Although the promoter of c-MYC has been investigated for its mechanism of fragility, little is known about other c-MYC breakpoint regions.

Comprehensive review on lignocellulosic biomass derived biochar production, characterization, utilization and applications.

Biochar is an ample source of organic carbon prepared by the thermal breakdown of biomass. Lignocellulosic biomass is a promising precursor for biochar production, and has several applications in various industries. In addition, biochar can be applied for environmental revitalization by reducing the negative impacts through intrinsic mechanisms.

Phytochemical Composition and Antioxidant and Anti-Inflammatory Activities of Sasidh. & Sujanapal, an Endemic Medicinal Plant to the Western Ghats.

Ethnomedicinal plants are important sources of drug candidates, and many of these plants, especially in the Western Ghats, are underexplored. , a genus within the Fabaceae family, thrives in the biodiversity of the Western Ghats, Kerala, India, and holds significant ethnobotanical importance. However, many species remain understudied in terms of their biological efficacy, while some lack scientific validation for their traditional uses.

Effect of silicon carbide on kerf convergence and irregularity of the surface during abrasive water jet machining of fiber-metal hybrid composites.

The traditional way to machine hybrid composites is hard because they tend to break, have a high retraction, have a high service temperature, and have an uneven surface irregularity. For high-strength fiber/metal composite constructions, alternative machining methods have drawn interest as a solution to these problems. Current research focuses on enhancing the Abrasive Water Jet Machining process by optimizing its variables using a composite material of epoxy reinforced with silicon carbide, stainless steel wire mesh, and Kevlar.

MAO-B Inhibitor (2E)-3-(4-Bromophenyl)-1-(1H-indol-3-yl) prop-2-en-1-one as a Neuroprotective Agent Against Alzheimer's Disease.

Chalcones (trans-1,3-diphenyl-2-propen-1-ones) form simple chemical structures that act as precursors for the biogenesis of flavonoids. These are distributed in plants and have two aromatic or heteroaromatic rings connected by a three-carbon α, β-unsaturated carbonyl group. Considering the importance of chalcones as monoamine oxidase and acetylcholinesterase inhibitors, the study was designed as a comprehensive and systematic analysis to evaluate the pharmacological activities leading to the formation of drug molecules against Alzheimer's disease (AD).

Chemical, Pharmacological, and Theoretical Aspects of Some Transition Metal(II) Complexes Derived from Pyrrole Azine Schiff Base.

Some new transition metal complexes were prepared by reacting metal(II) salts with Schiff base azines, which were prepared via condensation of 5-(diethylamino) salicylaldehyde and hydrazine with pyrrole-2-carbaldehyde. Their structures were confirmed based on CHN, UV-visible, FT-IR, and EPR measurements. The complexes were also assessed for their antibacterial, antioxidant, and anticancer properties.

Computational Analysis of Some More Rectangular Tessellations of Kekulenes and Their Molecular Characterizations.

Cycloarene molecules are benzene-ring-based polycyclic aromatic hydrocarbons that have been fused in a circular manner and are surrounded by carbon-hydrogen bonds that point inward. Due to their magnetic, geometric, and electronic characteristics and superaromaticity, these polycyclic aromatics have received attention in a number of studies. The kekulene molecule is a cyclically organized benzene ring in the shape of a doughnut and is the very first example of such a conjugated macrocyclic compound.

Synthesis of Bis-Chalcones and Evaluation of Its Effect on Peroxide-Induced Cell Death and Lipopolysaccharide-Induced Cytokine Production.

Plant secondary metabolites are important sources of biologically active compounds with wide pharmacological potentials. Among the different classes, the chalcones form integral pharmacologically active agents. Natural chalcones and bis-chalcones exhibit high antioxidant and anti-inflammatory properties in various experiments.

Spectroscopic, Biological, and Topological Insights on Lemonol as a Potential Anticancer Agent.

A monoterpene alcohol known as lemonol was investigated experimentally as well as theoretically in order to gain insights into its geometrical structure, vibrational frequencies, solvent effects on electronic properties, molecular electrostatic potential, Mulliken atomic charge distribution, natural bond orbital, and Nonlinear Optical properties. The frontier molecular orbital energy gap values of 5.9084 eV (gas), 5.

Exploring the Inclusion Complex of an Anticancer Drug with β-Cyclodextrin for Reducing Cytotoxicity Toward the Normal Human Cell Line by an Experimental and Computational Approach.

The toxicity of any drug against normal cells is a health hazard for all humans. At present, health and disease researchers from all over the world are trying to synthesize designer drugs with diminished toxicity and side effects. The purpose of the present study is to enhance the bioavailability and biocompatibility of gemcitabine (GEM) by decreasing its toxicity and reducing deamination during drug delivery by incorporating it inside the hydrophobic cavity of β-cyclodextrin (β-CD) without affecting the drug ability of the parent compound (GEM).

Carbon stock in biomass pool of fragmented mangrove habitats of Kochi, Southern India.

Even though, the blue carbon ecosystems are gaining keen research interest around the globe, the carbon stock of South-West coast of India was poorly reported, and this study is a pioneer attempt and will be an important document for filling the gaps in uncertainties in global carbon stock assessment and also will increase knowledge on biomass variability among mangrove species and mangrove habitats. The study also highlighted the vital role of biomass carbon pool for long-term soil carbon burial. We estimated the above and below-ground biomass carbon stock of 13 mangrove species using two common allometric equations and species-specific equations and reported a very high mean total living biomass carbon stock of Kochi mangroves at 237.

Conversion of solid wastes and natural biomass for deciphering the valorization of biochar in pollution abatement: A review on the thermo-chemical processes.

This overview addresses the formation of solid trash and the various forms of waste from a variety of industries, which environmentalists have embraced. The paper investigates the negative effects on the environment caused by unsustainable management of municipal solid trash as well as the opportunities presented by the formal system. This examination looks at the origins of solid waste as well as the typical treatment methods.

Deleterious effect of gestagens from wastewater effluent on fish reproduction in aquatic environment: A review.

Gestagens are common pollutants accumulated in the aquatic ecosystem. Gestagens are comprised of natural gestagens (i.e.

Checklist of Indian Harpalinae Bonelli, 1810 (Coleoptera: Carabidae).

An updated checklist of 169 species of subfamily Harpalinae known from the Indian mainland, along with details of the revisions by modern workers, literatures and distribution patterns is provided. Of them, 39 species are endemic to the Indian mainland, whereas 11 species to the Western Ghats Hotspot of Biodiversity, one to the Indo-Burma Hotspot of Biodiversity and eight to the Himalaya Hotspot of Biodiversity. Four genera, Allosiopelus Ito, 1995, Indocarterus Kataev & Wrase, 2018, Oesyperus Andrewes, 1923 and Panagrius Andrewes, 1933 are endemic to the Indian mainland.

A new species of the genus Clypeuspinus Balkenohl, 2021 (Coleoptera: Carabidae: Scaritinae) from India.

The description of a new carabid species from Indian mainland belonging to the genus Clypeuspinus Balkenohl, 2021 which was formerly known in Sri Lanka. Revised generic characteristics of Clypeuspinus, and a key to species are provided.