69 results match your criteria: "St. John's Hospital for Diseases of the Skin[Affiliation]"

The effect of nifedipine on subjective symptoms and objective dermographometer induced whealing was assessed independently in two double-blind cross-over trials in which active drug or placebo were taken for 2 weeks. The lower dose study used nifedipine 5 mg 3 times daily and gave rise to symptomatic improvement as assessed by diary card and visual analogue scale in 5 of 11 patients. This was not statistically significant and was not accompanied by a reduction in dermographometer-induced wheal and flare responses except at highest pressures.

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This review describes the history of rubber technology and the manufacturing techniques used in rubber manufacturing industries. The important aspects of the acquisition of allergic and irritant contact dermatitis within the industry are presented for the reader.

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I hope that this brief review has been sufficient to prove the importance that looking at patients' work should have in the investigation of suspected occupational dermatoses. For the dermatologist subspecializing in occupational cases, visits are, I believe, a continuing necessity in the weekly routine. For all other dermatologists, even occasional visits can make an important contribution to the accuracy with which diagnoses and advice on prevention can be provided in suspected cases of occupational dermatoses.

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Hand eczema among 50 caterers was occupational in 47 and endogenous in 3 cases. Irritants were considered more important than sensitisers. There was a correlation between atopy and sensitisation to type-I but not type-IV allergens.

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Mortality and malignancy were studied in a series of 32 patients with xeroderma pigmentosum presenting during the period 1950-84. Twenty-nine of the patients were followed to the end of 1984 using the National Health Service Central Register, and hospital case records and correspondence with referring physicians; three patients had incomplete follow-up. Three of the patients developed malignant melanoma during follow-up, but none developed internal malignancy.

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The patients sensitised to sunscreen agents who attended our Contact Dermatitis Clinic between February 1985 to March 1987 have been reviewed. 15 (5%) of 280 patients tested with sunscreens had positive reactions; 3 of them were allergic to more than one agent. The most frequent contact allergens were hydroxy methoxy methyl benzophenone (Mexenone) [6], followed by isopropyl dibenzoylmethane (Eusolex 8020/8021) [5], octyl dimethyl para-aminobenzoate (Escalol 507) [2], and one reaction each to butyl methoxy dibenzoylmethane (Parsol 1789), amyl dimethyl para-aminobenzoate (Escalol 506), and ethoxy ethyl-p-methoxy cinnamate (Givtan F).

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We describe a patient with Klinefelter's syndrome complicated by recalcitrant leg ulcers, in whom marked platelet hyperaggregability was demonstrated and venous disease excluded. Androgen replacement therapy appeared to bring about healing of the patient's ulcers and was associated with reversal of the platelet abnormality. The possible role of androgen deficiency in the pathogenesis of leg ulceration is discussed.

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The time-course of cutaneous inflammatory responses to LTB4 and PGE2 both alone and in combination has been studied in 10 healthy volunteers. LTB4 induced a transient wheal and flare response in some subjects, maximal at 15 minutes and succeeded by an erythematous, indurated lesion at 2-4 hours. PGE2 elicited a wheal and erythema response which resolved within 1-2 hours.

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The pigmented spindle cell tumor is a distinct benign melanocytic lesion with characteristic clinical and histopathologic features. Until recently, it has been poorly documented in the literature and is frequently misdiagnosed as malignant melanoma. On the basis of 40 personal cases of pigmented spindle cell tumor, the clinical and pathologic features of the lesion and its differential diagnosis will be discussed.

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