Plakin Expression in Serous Epithelial Ovarian Cancer Has the Potential to Impede Metastatic Spread and Epithelial-Mesenchymal Transition: A Comparative Expression Analysis of Immunohistochemical and In Silico Datasets.

Epithelial ovarian cancer is aggressive and causes high mortality among women worldwide. Members of the plakin family are essential to maintain cytoskeletal integrity and key cellular processes. In this study we characterised the expression of plakins, particularly plectin (PLEC), periplakin (PPL), envoplakin (EVPL), and EMT-related proteins by immunohistochemistry in n = 48 patients' samples to evaluate a potential correlation of plakin expression with EMT as EOC progresses.

Impact of diabetes mellitus on mortality in pulmonary hypertension: A systematic review and meta-analysis.

Background: Pulmonary hypertension (PH) is a progressive disease characterized by endothelial dysfunction and vascular remodeling and is a leading cause of mortality worldwide. Although it is independently associated with multiple comorbidities, the impact of diabetes mellitus (DM) on mortality in patients with PH remains uncertain. To address this issue, we conducted a systematic review and meta-analysis to investigate the effect of DM on survival in patients with pulmonary hypertension.

The Support, Education and Learning Needs of Experienced Nurses Who Are Transitioning to Work in Intensive Care: A Scoping Review.

Aim: To ascertain the current evidence about the support, education and learning needs of experienced registered nurses who are transitioning their work to intensive care nursing as a new context.

Design: A scoping review was conducted using established frameworks from JBI, Arksey and O'Malley.

Methods: A search was conducted in CINHAL and MEDLINE (April 2023).

A personalized smartphone app for a surgery residency: Is it useful?

Background: Access to schedules, protocols, and learning materials needs to be convenient and fast. Smartphones have become the default pathway for information access. The purpose of this study was to understand the impact of a smartphone application (app) on residency workflow and education.

Volumetric Artificial Intelligence Analysis of Prerupture and Postrupture Cerebral Aneurysms: Assessment of Morphologic Change.

Background: Cerebral aneurysm rupture is a major cause of potential years of life lost. Research on rupture risk has often compared unruptured and ruptured aneurysms, with the implicit assumption that the rupture event does not significantly change aneurysm morphology. However, aneurysm morphology is charged by rupture, although precisely how remains a matter of debate.

External validation and performance analysis of a deep learning-based model for the detection of intracranial hemorrhage.

Purpose: We aimed to investigate the external validation and performance of an FDA-approved deep learning model in labeling intracranial hemorrhage (ICH) cases on a real-world heterogeneous clinical dataset. Furthermore, we delved deeper into evaluating how patients' risk factors influenced the model's performance and gathered feedback on satisfaction from radiologists of varying ranks.

Methods: This prospective IRB approved study included 5600 non-contrast CT scans of the head in various clinical settings, that is, emergency, inpatient, and outpatient units.

Delayed Appearance of Neuropathy After Inferior Shoulder Dislocation.

Complications regarding inferior shoulder dislocations (ISD) are predominately rotator cuff injuries, neuropathies, and vascular insults. To our knowledge, there are no studies regarding the delayed appearance of neuropathies with inferior shoulder dislocations. A 32-year-old previously healthy male presented with an inferior shoulder dislocation that required open reduction and internal fixation after failed attempts at closed reductions in the emergency room and operating room.

Nomophobia: a challenge among healthcare professionals in Africa.

Objectives: This study delves into implementing Global Provider's phone-lessness phobia (Global 3-P Study) within the healthcare sector in Africa through a multinational, cross-sectional, web-based survey from April 1st to 30 June 2023.

Methods: Utilizing a modified Nomophobia Questionnaire (NMP-Q), the research explores four dimensions of nomophobia: the inability to communicate, loss of connectedness, difficulty accessing information, and sacrificing convenience. The Global Remote Research Scholars Program (GRRSP) conducted the study, employing a 'snowball technique' for survey dissemination.

Outpatient Neurosurgery: ASCs and the Medicolegal Landscape.

The purpose of this work is to provide an understanding of the medicolegal landscape with regards to ambulatory surgery centers and physician owned hospitals, trends in our healthcare system, the benefits of facility ownership for both outpatient and inpatient spine surgery, and the effect of each on physicians and patients.

Pharmacological modulation of respiratory control: Ampakines as a therapeutic strategy.

Ampakines are a class of compounds that are positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and enhance glutamatergic neurotransmission. Glutamatergic synaptic transmission and AMPA receptor activation are fundamentally important to the genesis and propagation of the neural impulses driving breathing, including respiratory motoneuron depolarization. Ampakines therefore have the potential to modulate the neural control of breathing.

A Study on the Glucose Breath Test Positivity Rate and Occurrence of Small Intestine Bacterial Overgrowth-Related Symptoms Caused by Long-Term Use of Proton Pump Inhibitor (PPI) Versus Potassium-Competitive Acid Blocker (P-CAB) in Elderly Patients: SIBO Between PPI and P-CAB.

Long-term acid suppression with proton pump inhibitors (PPI) leads to hypochlorhydria and facilitates the growth of bacterial flora in the small intestine. Novel acid-suppressants called potassium-competitive acid blockers (P-CABs) seem to be superior to PPIs. However, data on the risk of small intestinal bacterial overgrowth (SIBO) in patients taking P-CABs are limited.

Top-100 Highest Cited Articles on Posterior Communicating Artery Aneurysms: A Bibliometric Analysis.

Objective: The aim of this study is to evaluate the 100 most highly cited articles assessing posterior communicating artery aneurysms.

Methods: In May 2024, a comprehensive search was conducted in the Scopus database using the keyword "posterior communicating artery aneurysm" The top-100 most impactful articles were ranked by citation count and analyzed for relevant factors. Citations per year were calculated to minimize the risk of bias.

Assessment of trabecular bone score using updated TBSTT in anorexia nervosa-The AN-BO study.

Objective: Anorexia Nervosa (AN) is characterized by a distortion of body image, very low body weight, malnutrition and hormonal dysregulations, resulting in reduced bone mineral density (BMD) and impaired bone microarchitecture. The updated Trabecular Bone Score (TBS) algorithm accounts for soft tissue thickness (TBSTT) instead of BMI (TBSBMI). The aim of the study was to assess both TBS algorithms in adult AN patients compared to normal-weight controls(CTRL).

Retrospective study evaluating association of colorectal tumors and hepatitis C virus.

Background: Chronic hepatitis C virus (HCV) has been associated with hepatic and extrahepatic malignancies. Limited studies have shown an association between colorectal adenomas and HCV populations.

Aim: To study the prevalence of colorectal adenomas in patients with HCV compared to the general population and to evaluate if it is an independent risk factor for colorectal adenomas.

Longitudinal course of circulating miRNAs in a patient with hypophosphatasia and asfotase alfa treatment: a case report.

Hypophosphatasia (HPP) is characterized by low activity of tissue nonspecific alkaline phosphatase (TNSALP). The enzyme replacement therapy asfotase alfa has been approved for childhood-onset forms of HPP. MicroRNAs (miRNAs) have emerged as a novel disease biomarker, with potential application in therapy monitoring.